Short CV/Education and training

  •  
    until 1999 MD: University Utrecht, Utrecht, the Netherlands

  • 2004
    PhD cum laude, Radboud University Nijmegen (NWO AGIKO). Subject: Hereditary autoinflammatory syndromes, with emphasis on hyper-IgD and periodic fever syndrome (supervisor: Prof. dr. J.W.M. van der Meer)

  • 2006 – 2007
    Visiting postdoctoral fellow at the National Institute of Health, Bethesda, MD, USA. Subject: Intracellular accumulation of mutant TNFR1 drives inflammatory cytokine production in the TNFR1-associated periodic fever syndrome (TRAPS) through Mitogen-Activated Protein Kinases and Reactive Oxygen Species (supervisor: dr. D. Kastner)

  • 2008 – 2009
    Postdoctoral researcher Department of General Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands

  •  
    until 2009 Internal Medicine speciality training, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands

  • 2009 – 2010
    Clinical fellowship Infectious Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands

  • Since 2010
    Associate professor of Autoinflammatory disease and Immunodeficiency, Junior Principal Investigator, Internist and Infectious Diseases specialist, Dept of General Internal Medicine, Radboud University Nijmegen Medical Centre, the Netherlands

Selected publications

  • de Koning HD, Schalkwijk J, van der Ven-Jongekrijg J, Stoffels M, van der Meer JW, Simon A. Sustained efficacy of the monoclonal anti-interleukin-1 beta antibody canakinumab in a 9-month trial in Schnitzler's syndrome. Ann Rheum Dis 2012, Epub

  • Dinarello CA, Simon A, Van der Meer JWM. Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases. Nat Rev Drug Discov 2012; 11:633-52

  • Bodar EJ, Kuijk L, Drenth JPH, Van der Meer JWM, Simon A*, Frenkel J*. On demand anakinra treatment is effective in mevalonate kinase deficiency. Ann Rheum Dis 2011; 70:1168-70

  • Bulua AC, Simon A, Maddipati R, Pelletier M, Park H, Kim KY, Sack MN, Kastner DL, Siegel RM. Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS). J Exp Med 2011; 208:519-33

  • Simon A, Park H, Maddipati R, Bulua A, Jackson AJ, Chae JJ, Ettinger R, de Koning HD, Lobito AA, Kastner DL, Komarow H, Siegel RM. Concerted Action of Wild-type and Mutant TNF Receptors Enhances Inflammation in TNFR1-Associated Periodic Fever Syndrome (TRAPS). Proc Natl Acad Sci U S A. 2010 May 25;107(21):9801-6

  • Masters SL, Simon A, Aksentijevich I, Kastner DL. Horror Autoinflammaticus: the molecular pathophysiology of Autoinflammatory Disease. Annu. Rev. Immunol. 2009; 27:621-668



Complete list of publications

Membership in scientific bodies/juries

  • Nijmegen Institute for Infection, Inflammation and Immunity (N4i)

  • Nijmegen Centre for Molecular Life Sciences (NCMLS)

  • Eurofever

  • EAACI Taskforce Autoinflammation

  • Dutch Interuniversity Working Group on Autoinflammation (chair)

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