Short CV/Education and training

Qualifications:

  • 1992
    B.Sc. (Med. Sci.) Pathology (1st Class)

  • 1995
    MB ChB (Honours) Edinburgh University

  • 1998
    M.R.C.P. (U.K.)

  • 2003
    Ph.D. The Periaxin gene in human and mouse demyelinating peripheral neuropathy.

  • 2009
    F.R.C.P. (UK)

  • 2007
    CCT awarded (Neurology)

Employment History:

  • 1995 – 1996
    Junior House Officer, Edinburgh.

  • 1996 – 1998
    Medical Senior House Officer Rotation, Edinburgh.

  • 1999 – 2002
    PhD research Fellow in Neurology, Department of Preclinical Vet Sciences, University of Edinburgh. Supervisor: Prof. Peter Brophy

  • 2004 – 2006
    Post-doctoral research position Violet Nasmyth Travelling Fellowship from Medical Research Scotland. INSERM U711, l'hôpital de la Salpêtrière, Paris, France. Supervisor- Prof. Catherine Lubetzki.

  • 1998 – 2008
    Registrar Training in Neurology, Edinburgh.

  • 2008
    Locum consultant in Neurology at the Borders General Hospital.

  • 2008 – 2013
    Wellcome Trust Intermediate Fellow and Honorary Neurology Consultant

  •  
    Current Post Scottish Senior Clinical Research Fellow and Honorary Neurology Consultant

Selected publications

  • Muenzel EJ, Williams A. Promoting Remyelination in Multiple Sclerosis – recent advances. Drugs 2013 Dec. 73(18):2017-29. doi: 10.1007/s40265-013-0146-8.

  • Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, van Wijngaarden P, Wagers AJ,Williams A, Franklin RJ, Ffrench-Constant C. M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci. 2013 Sep;16(9):1211-8. doi: 10.1038/nn.3469. Epub 2013 Jul 21.

  • Boyd A, Zhang H, Williams A. Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models. Acta neuropathologica 2013 Jun;125(6):841-59. doi: 10.1007/s00401-013-1112-y. Epub 2013 Apr 18.

  • Yuen TJ, Johnson KR, Miron VE, Zhao C, Quandt J, Harrisingh MC, Swire M, Williams A, McFarland HF, Franklin RJ, Ffrench-Constant C. Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination. Brain. 2013 Apr;136(Pt 4):1035-47. doi: 10.1093/brain/awt024. Epub 2013 Mar 21.

  • Wu LMN, Williams A, Delaney A, Suter U, Sherman DL, Brophy PJ. Evidence that conduction velocities are regulated by the distance between nodes of Ranvier in myelinated nerves. Current Biology 2012 Oct 23;22(20):1957-61

  • Münzel EJ, Schaefer K, Obirei B, Kremmer E, Burton EA, Kuscha V, Becker CG, Brösamle C, Williams A*, Becker T*. Claudin k is specifically expressed in cells that form myelin during development of the nervous system and regeneration of the optic nerve in adult zebrafish. Glia. 2012 Feb;60(2):253-70. doi: 10.1002/glia.21260. Epub 2011 Oct 21. * joint last author

  • Jarjour AA, Zhang H, Bauer N, ffrench-Constant C, Williams A. In vitro modelling of Central Nervous System myelination and remyelination. Glia. 2012 Jan;60(1):1-12. doi: 10.1002/glia.21231. Epub 2011 Aug 19.

  • Zhang H, Jarjour AA, Boyd A, Williams A. Central nervous system remyelination in vitro – a tool for MS research. Exp Neurol. 2011 Jul;230(1):138-48

  • Piaton G, Aigrot MS, Williams A, Moyon S, Tepavcevic V, Moutkine I, Gras J, Matho K, Schmitt A, Soellner H, Huber AB, Ravassard P & Lubetzki C. Class 3 semaphorins influence oligodendrocyte precursors recruitment and remyelination in adult CNS. Brain. 2011 Apr;134(Pt 4):1156-67.

  • Huang JK, Jarjour AA, Oumesmar BN, Kerninon C, Williams A, Krezel W, Kagechika H, Bauer J, Zhao C, Evercooren AB, Chambon P, ffrench-Constant C, Franklin RJ. Retinoid X receptor gamma signaling accelerates CNS remyelination. Nat Neurosci. 2011 Jan;14(1):45-53.



Complete list of publications

Membership in scientific bodies/juries

  • External positions:

  • Scientific Advisory Committee of the French MS Society ARSEP.

  • Editorial board of Acta Neuropathologica Communications.

Media coverage

  • Interviewed on Material World for Radio 4; Feb 2012

  • Interviewed and filmed for Al Jazeera documentary about MS and MS research; June 2013

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