Short CV/Education and training

  • 1993 – 1996
    Research Assistant; Cytogenetics Laboratory, Department of Internal Medicine V, University Hospital of Heidelberg

  • 1996 – 2000
    Heidelberg University Medical School

  • 2000 – 2002
    Ulm University Medical School

  • 2002 – 2005
    Resident in Internal Medicine, Hematology, Oncology, Rheumatology, Infectious Diseases; Department of Internal Medicine III, University Hospital of Ulm (Prof. H. Döhner)

  • 2005 – 2009
    Postdoctoral Fellow; Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA (Prof. D. Gary Gilliland)

  • 2009 – 2014
    Principal Investigator; Research Group Molecular Cancer Biology, Ulm University

  • 2010 – 2014
    Junior Research Group Leader within the Emmy Noether Program of the German Research Foundation (DFG), Ulm University

  • since 2014
    Junior Research Group Leader within the Emmy Noether Program of the German Research Foundation (DFG), German Cancer Research Center (DKFZ),National Center for tumor diseases (NCT) Heidelberg

Selected publications

  • Faber K, Bullinger L, Ragu C, Garding A, Mertens D, Miller C, Martin D, Walcher D, Döhner K, Döhner H, Claus R, Plass C, Sykes SM, Lane SW, Scholl C,* Fröhling S.* (2013) CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPAR? signaling. J Clin Invest 123, 299-314. *Equal contribution.

  • Azoitei N, Hoffmann CM, Ellegast JM, Ball CR, Obermayer K, Gößele U, Koch B, Faber K, Genze F, Schrader M, Kestler HA, Döhner H, Chiosis G, Glimm H, Fröhling S,* Scholl C.* (2012) Targeting of KRAS mutant tumors by HSP90 inhibitors involves degradation of STK33. J Exp Med 209, 697-711. *Equal contribution.

  • Scholl C,* Fröhling S,* Dunn IF, Schinzel AC, Barbie DA, Kim SY, Silver SJ, Tamayo P, Wadlow RC, Ramaswamy S, Döhner K, Bullinger L, Sandy P, Boehm JS, Root DE, Jacks T, Hahn WC, Gilliland DG (2009). Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells. Cell 137, 821-834. *Equal contribution.

  • Fröhling S,* Scholl C,* Levine RL, Loriaux M, Boggon TJ, Bernard OA, Berger R, Döhner H, Döhner K, Ebert BL, Teckie S, Golub TR, Jiang J, Schittenhelm MM, Lee BH, Griffin JD, Stone RM, Heinrich MC, Deininger MW, Druker BJ, Gilliland DG (2007). Identification of driver and passenger mutations of FLT3 by high-throughput DNA sequence analysis and functional assessment of candidate alleles. Cancer Cell 12, 501-513. *Equal contribution.

  • Scholl C, Bansal D, Döhner K, Eiwen K, Huntly BJ, Lee BH, Rücker FG, Schlenk RF, Bullinger L, Döhner H, Gilliland DG, Fröhling S (2007). The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis. J Clin Invest 117, 1037-1048.


Selected projects

  • Identification of genetic vulnerabilities in acute myeloid leukemia (AML) and solid cancers using functional genomics

  • Role of the serine/threonine kinase STK33 in mutant KRAS-driven oncogenesis

  • Role of the homeobox transcription factor CDX2 in AML pathogenesis

  • Characterization of normal and malignant stem cells of the lung

Membership in scientific bodies/juries

Memberships:

  • American Society of Hematology (ASH)

  • American Association for Cancer Research (AACR)

  • European Hematology Association (EHA)

Review Activities:

  • Journals: Blood, International Journal of Cancer, Leukemia

  • Conferences: ASH Annual Meeting 2011 and 2012 (Coordinating Reviewer), EHA Annual Congress 2007 and 2011

  • Organizations: DFG, Else Kröner-Fresenius Foundation, José Carreras Leukemia Foundation, Portuguese Foundation for Science and Technology (FCT)

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