Short CV/Education and training

  • 1996 – 2001
    Studies of Biochemistry, Eberhard-Karls-Universität Tübingen, Germany

  • 1999 – 2000
    Studies of Biochemistry, University of North Carolina, Chapel Hill, USA

  • 2002
    Diploma in Biochemistry (Thesis advisor: Prof. Dr. Ralph Steinman, Rockefeller University, New York, USA)

  • 2003 – 2007
    Graduate studies, Rockefeller University, New York, USA

  • 2007
    Ph.D. (Thesis advisor: Prof. Dr. Christian Münz, Rockefeller University, New York, USA)

  • 2007 – 2013
    Postdoctoral Fellow with Prof. Dr. Christian Haass, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) & Ludwig-Maximilians-Universität München, Germany

  • Since 2014
    Emmy Noether research group leader, BioMedical Center (BMC), Ludwig-Maximilians-Universität München, Germany

Selected publications

  • Hofweber M, Dormann D#. “Friend or foe – post-translational modifications as regulators of phase separation and RNP granule dynamics”, J. Biol. Chem pii: jbc.TM118.001189 (2018)

  • Ederle H, Funk C, Abou-Ajram C, Hutten S, Funk EBE, Kehlenbach R, Bailer S, Dormann D#. Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1, Scientific Reports 8(1):7084 (2018)

  • Hofweber D*, Hutten S*, Bourgeois B, Spreitzer E, Niedner-Boblenz A, Schifferer M, Ruepp MD, Simons M, Niessing D, Madl T, Dormann D#. Phase separation of FUS is suppressed by its nuclear import receptor and arginine methylation. Cell 173:706–719 (2018)

  • Ederle H, Dormann D#. TDP-43 and FUS – en route from the nucleus to the cytoplasm. FEBS Letters 591(11):1489-1507 (2017)

  • Bowden H, Dormann D#. Altered mRNP granule dynamics in FTLD pathogenesis. J Neurochem 138 Suppl 1:112-33 (2016)

  • Suárez-Calvet M, Neumann M, Arzberger T, Abou-Ajram C, Funk E, Hartmann H, Edbauer D, Kremmer E, Göbl C, Resch M, Bourgeois B, Madl T, Reber S, Jutzi D, Ruepp MD, Mackenzie IR, Ansorge O, Dormann D#, Haass C#. Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. Acta Neuropathol 131:587-604 (2016)

  • Bentmann E, Haass C, Dormann D#. (2013) Stress granules in neurodegeneration – lessons learnt from FUS and TDP-43. FEBS J. 280(18):4348-70

  • Dormann D#, Madl T, Valori C, Bentmann E, Tahirovic S, Abou-Ajram C, Kremmer E, Ansorge O, Mackenzie IR, Neumann M, Haass C#. (2012) Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS. EMBO J. 31(22):4258-75

  • Bentmann E, Neumann M, Tahirovic S, Rodde R, Dormann D#, Haass C#. (2012) Requirements for stress granule recruitment of Fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43). J Biol Chem. 287(27):23079-94

  • Dormann D, Haass C. (2011) TDP-43 and FUS – A nuclear affair. Trends Neurosci. 34(7) pp. 339-348

  • Dormann D, Rodde R, Edbauer D, Bentmann E, Fischer I, Hruscha A, Than M, Mackenzie I, Capell A, Schmid B, Neumann M, Haass C. (2010) ALS-associated FUS mutations disrupt Transportin-mediated nuclear transport. EMBO J. 29(16):2841-57

  • Dormann D*, Capell A*, Carlson AM, Shankaran SS, Rodde R, Neumann M, Kremmer E, Matsuwaki T, Yamanouchi K, Nishihara M, Haass C. (2009) Proteolytic processing of TAR DNA Binding Protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin. J Neurochem. 110(3):1082-94

  • Schmid D, Pypaert M, Münz C. (2007) MHC class II antigen loading compartments continuously receive input from autophagosomes. Immunity 26(1):79-92

  • Paludan C*, Schmid D*, Landthaler M, Vockerodt M, Kube D, Tuschl T, Münz C. (2005) Endogenous MHC class II processing of a viral nuclear antigen after autophagy. Science 307(5709):593-6

  • Notes: Schmid D = Dormann D (since 2007)

    *equal contribution; # corresponding autor


Membership in scientific bodies/juries

  • Principal Investigator in the Munich Cluster for Systems Neurology (SyNergy), EXC 2145, since 2019

  • Member of the German Neuroscience Society (NWG) and Federation of European Neuroscience Societies (FENS), since 2018

  • Faculty Member of Faculty of 1000, since 2016

  • Member of the Munich Center for Neurosciences (MCN), since 2015

  • Associate Investigator of the Munich Cluster for Systems Neurology (SyNergy), since 2014

  • Member of the Center for Advanced Studies (CAS), Ludwig-Maximilians-University Munich, since 2014

  • Associate Faculty Member of the Graduate School of Systemic Neurosciences (GSN) Munich, since 2013

Media coverage

  • http://www.zellbio.anatomie.med.uni-muenchen.de/about_us/dorothee-dormann/news-and-announcements/index.html

  • https://www.en.uni-muenchen.de/news/newsarchiv/2019/dormann_neurodegeneration.html

  • https://www.uni-frankfurt.de/75764421/2019

  • https://medicalxpress.com/news/2018-04-mechanism-protein-accumulation-neurodegenerative-diseases.html

Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Married, 2 children


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