Short CV/Education and training

  • 2005
    PhD in Biomedical Engineering at Tulane University (USA)

  • 2005
    Christine Mirzayan Science and Technology Policy Graduate Fellow, National Academy of Engineering Program Office, The National Academies, Washington, DC, USA

  • 2005 – 2006
    Post-Doctoral Research Associate, Centre for Tissue Engineering and Regenerative Medicine, Imperial College London, UK

  • 2006 – 2011
    Post-Doctoral Research Associate, Department of Materials and Institute of Biomedical Engineering, Imperial College London, UK

  • 2011 – 2017
    Wellcome Trust Research Career Development Fellow, Centre

    for Craniofacial and Regenerative Biology, King's College London, UK

  • Since 2017
    Senior Research Fellow and Principal Investigator, Centre for Craniofacial and Regenerative Biology, King's College London, UK

Selected publications

  • Ferreira SA, Motwani MS, Faull PA, Seymour AJ, Yu TTL, Enayati M, Taheem DK, Kania EM, Oommen OP, Ahmed T, Loaiza S, Parzych K, Dazzi F, Auner HW, Varghese OP, Festy F, Grigoriadis AE, Snijders AP, Bozec L, Gentleman E (2018) “Bi-directional cell-pericellular matrix interactions direct stem cell fate.” Nature Communications. 9:4049. doi: 10.1038/s41467-018-06183-4

  • Loaiza S‡, Ferreira SA‡, Chinn TM, Kirby A, Tsolaki E, Dondi C, Parzych K, Strange AP, Bozec L, Bertazzo S, Hedegaard MAB, Gentleman E*, Auner HW* (2018) “An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical properties.” ‡equal contribution, *joint corresponding authors. Biomaterials. 183:102-13. doi: 10.1016/j.biomaterials.2018.08.041

  • Ferreira SA, Faull PA, Seymour A, Yu TTL, Loaiza S, Auner HW, Snijders AP, Gentleman E (2018) “Neighboring cells override 3D hydrogel matrix cues to drive human MSC quiescence.” Biomaterials. 176:13-23. doi: 10.1016/j.biomaterials.2018.05.032

  • Taheem DK, Foyt DA, Loaiza S, Ferreira SA, Ilic D, Auner HW, Grigoriadis AE, Jell G, Gentleman E (2018) “Differential regulation of human marrow stromal cell chondrogenesis by HIF-1 hydroxylase inhibitors.” STEM CELLS. 36:1380-92. doi: 10.1002/stem.2844

  • Foyt DA‡, Norman MDA‡, Yu TTL‡, Gentleman E (2018) “Exploiting Advanced Hydrogel Technologies to Address Key Challenges in Regenerative Medicine.” Advanced Healthcare Materials. 1700939. doi: 10.1002/adhm.201700939. ‡equal contribution

  • Bertazzo S, Gentleman E (2016) “Aortic valve calcification: A bone of contention.” European Heart Journal. http://dx.doi.org/10.1093/eurheartj/ehw071.

  • Autefage H, Gentleman E, Littmann E, Hedegaard MAB, von Erlach T, O’Donnell MD, Burden FR, Winkler DA, Stevens MM (2015) “Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials.” Proceedings of the National Academy of Sciences USA. 112(14):4280-85.

  • Bertazzo S, Gentleman E, Cloyd KL, Chester AH, Yacoub M, Stevens MM (2013) Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification. Nature Materials. 12(6):576-83. Front cover article.

  • Boonrungsiman S, Gentleman E, Carzaniga R, Evans ND, McComb DW, Porter A, Stevens MM (2012) The Role of Intracellular Calcium Phosphate in Osteoblast-Mediated Bone Apatite Formation. Proceedings of the National Academies of Science USA. 109(35):14170-5.

  • Gentleman E, Fredholm YC, Jell G, O?Donnell MD, Lotfibakhshaiesch N, Hill RG, Stevens MM (2010) The Effects of Strontium-Substituted Bioactive Glasses on Osteoblasts and Osteoclasts in vitro. Biomaterials. 31(14):3949-3956.

  • Evans ND, Minelli C, Gentleman E, LaPointe V, Patankar SN, Kallivretaki M, Chen X, Roberts CJ, Stevens MM (2009) Substrate Stiffness Affects Early Differentiation Events in Embryonic Stem Cells. European Cells and Materials.18:1-14.

  • Gentleman E, Swain RJ, Evans ND, Boonrungsiman S, Jell G, Ball MD, Shean, TAV, Oyen ML, Porter A, Stevens, MM (2009) Comparative Materials Differences Revealed in Engineered Bone as a Function of Cell-Specific Differentiation. Nature Materials. 8(9):763-70.

  • Gentleman E, Lay AN, Dickerson DA, Nauman EA, Livesay GA, Dee KC (2003) Mechanical Characterization of Collagen Fibers and Scaffolds for Tissue Engineering. Biomaterials. 24:3805-13.



Complete list of publications

Selected projects

  • Dr Gentleman's research focuses on engineering the 3D cell niche to control stem cell differentiation for tissue engineering, particularly to regenerate osteochondral tissue. Her multi-disciplinary research interests also include fundamental mechanisms of biomineralisation and the role of mechano-sensing in tissue development. She has also worked extensively with bioactive glasses, and is interested in the biological effects of surface free energy and ion release on stem cell differentiation.

Membership in scientific bodies/juries

  • European Society for Biomaterials

  • British Orthopaedic Research Society

  • UK Tissue & Cell Engineering Society

  • Institute of Materials, Minerals and Mining (IOM3)

Media coverage

  • The Guardian, I Tucker, “The Wellcome Image awards: nature’s hidden landscape – in pictures.” 6 March 2016, http://gu.com/p/4h8en/sbl

  • BBC Feature, P Kerley, “The 20 best science images of the year?” 7 March 2016, bbc.in/21gFuYD

  • Financial Times “Medical photography: a world we never see.” 5 March 2016, http://on.ft.com/1TY27k0

  • Associated Press feature, M. Cheng “UK scientists make body parts in the lab” http://bigstory.ap.org/article/uk-scientists-make-body-parts-lab, 8 April 2014.

  • Gentleman E Commentary: field of tissue engineering is progressing at remarkable pace. 02 March 2014, The Telegraph (UK). http://t.co/avkMoLJiib

  • Wellcome Trust Feature article: P. Bailey. Deceptive appearances: Engineering cartilage. 26 April 2012

  • The Clydesdale Bank and Yorkshire Bank Journal. Regenerating a Profit: Why Britain Leads the World in Tissue Creation Science. Issue 5, Summer 2012

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