Short CV/Education and training

  • 1990 – 1996
    Master's degree in Biology (cum laude) at Ferrara University, Italy. Main subject: molecular genetics

  • 1997
    Qualification as a Professional Biologist

  • 1996 – 2001
    PhD at the Department of Biochemistry and Molecular Biology of Ferrara University, Italy, with the thesis: 'Molecular bases of APC resistance and factor V deficiency in thrombophilia'. Supervisors: Prof. F. Conconi and Prof. F. Bernardi

  • 2001 – 2006
    Post-doctoral training at the Department of Biochemistry of Maastricht University, The Netherlands. Supervisor: Prof. J. Rosing

  • 2006 – 2009
    Assistant Professor at the Department of Biochemistry of Maastricht University, The Netherlands

  • Since 2009
    Associate Professor at the Department of Biochemistry of Maastricht University, The Netherlands

Selected publications

  • Bernardi F, Faioni EM, Castoldi E, Lunghi B, Castaman G, Sacchi E, Mannucci PM. A factor V genetic component differing from factor V R506Q contributes to the activated protein C resistance phenotype. Blood 1997; 90: 1552–1557.

  • Castoldi E, Brugge JM, Nicolaes GAF, Girelli D, Tans G, Rosing J. Impaired APC-cofactor activity of factor V plays a major role in the APC resistance associated with the factor V Leiden (R506Q) and R2 (H1299R) mutations. Blood 2004; 103:4173–4179.

  • Brugge JM, Simioni P, Bernardi F, Tormene D, Lunghi B, Tans G, Pagnan A, Rosing J, Castoldi E. Expression of the normal factor V allele modulates the APC resistance phenotype in heterozygous carriers of the factor V Leiden mutation. J Thromb Haemost 2005; 3: 2695–2702.

  • Duckers C, Simioni P, Spiezia L, Radu C, Gavasso S, Rosing J, Castoldi E. Low plasma levels of tissue factor pathway inhibitor in patients with congenital factor V deficiency. Blood 2008; 112: 3615–3623.

  • Duckers C, Simioni P. Spiezia L, Radu C, Dabrilli P, Gavasso S, Rosing J, Castoldi E. Residual platelet factor V ensures thrombin generation in patients with severe congenital factor V deficiency and mild bleeding symptoms. Blood 2010; 115: 879–886.

  • Segers O, van Oerle R, ten Cate H, Rosing J, Castoldi E. Thrombin generation as an intermediate phenotype for venous thrombosis: a proof-of-concept study. Thromb Haemost 2010; 103: 114–122.

  • Castoldi E, Simioni P, Tormene D, Rosing J, Hackeng TM. Hereditary and acquired protein S deficiencies are associated with low TFPI levels in plasma. J Thromb Haemost 2010; 8: 294–300.

  • Castoldi E, Duckers C, Radu C, Spiezia L, Rossetto V, Tagariello G, Rosing J, Simioni P. Homozygous F5 deep-intronic splicing mutation resulting in severe factor V deficiency and undetectable thrombin generation in platelet-rich plasma. J Thromb Haemost 2011; 9: 959–968.

  • Castoldi E, Collins PW, Williamson PL, Bevers EM. Compound heterozygosity for two novel TMEM16F mutations in a patient with Scott syndrome. Blood 2011; 117: 4399–4400.


Selected projects

  • Long-Term Fellowship from the European Molecular Biology Organization (EMBO) for the project: Expression and functional characterization of coagulation factor V mutants derived from the factor V HR2 haplotype, 2001 – 2003

  • VIDI grant from the Netherlands Organisation for Scientific Research (NWO) for the project: Functional interactions of genetic defects affecting the protein C pathway in familial thrombophilia, 2006 – 2011

  • Research grant from the Dutch Thrombosis Foundation (TSN) for the project: Modulation of thrombin generation and activity by total fibrinogen and gamma-fibrinogen, since 2011

Membership in scientific bodies/juries

  • Member of the Italian National Registry of Professional Biologists

  • Member of the EMBO FellowsNet

  • Member of the Dutch Society on Thrombosis and Haemostasis (NVTH)

  • Member of the International Society on Thrombosis and Haemostasis (ISTH)

  • Co-chairman of the SSC Committee on Plasma Coagulation Inhibitors of the International Society on Thrombosis and Haemostasis (ISTH)

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