Short CV/Education and training

  • Jeanine Prompers is associate professor of Biomedical Magnetic Resonance Spectroscopy (MRS) in the department of Biomedical Engineering at Eindhoven University of Technology (the Netherlands). She studied Chemistry at the Radboud University Nijmegen (the Netherlands), where she graduated cum laude in 1994. The following years she performed a PhD project in the group of Prof. Dr. C.W. Hilbers at the Radboud University Nijmegen in the field of high-resolution protein MRS. In 1999, she obtained her PhD degree with a dissertation entitled "NMR studies of Fusarium solani pisi cutinase – Structure-mobility-function relationships". After her PhD, she was awarded a long-term postdoctoral fellowship from the Human Frontier of Science Program for two years of research with Prof. Brüschweiler (Clark University, USA). During this period, she studied correlated protein motions by a combined interpretation of MR relaxation data and molecular dynamics simulations. After her postdoc, she joined the Biomedical NMR group of Prof. Nicolay at Eindhoven University of Technology in 2002 as an assistant professor. Her research interest is to characterize metabolic disturbances underlying the etiology of metabolic disorders, such as insulin resistance and type 2 diabetes, using a multi-tissue approach. To this end she develops in vivo MRS methods to study metabolic processes in skeletal muscle, heart and liver, such as mitochondrial bioenergetics and intracellular lipid handling. In 2008, she was awarded a NWO VIDI grant entitled "In vivo magnetic resonance spectroscopy of lipid dynamics in insulin-resistant muscle". In 2012, she was promoted to associate professor.

Selected publications

  • Jonkers RA, Geraedts TR, van Loon LJ, Nicolay K, and Prompers JJ. Multi-tissue assessment of in vivo postprandial intracellular lipid partitioning in rats using localized 1H-[13C] MRS. Magn. Reson. Med. 68, 997-1006 (2012).

  • Prompers JJ, Strijkers GJ, and Nicolay K. Magnetic resonance spectroscopy of in vivo tissue metabolism in small animals. Drug Discov. Today: Technol. 8, e95-e102 (2011).

  • Bakermans AJ, Geraedts TR, van Weeghel M, Denis S, Ferraz MJ, Aerts JM, Aten J, Nicolay K, Houten SM, and Prompers JJ. Fasting-induced myocardial lipid accumulation in long-chain acyl-CoA dehydrogenase knock-out mice is accompanied by impaired left ventricular function. Circ. Cardiovasc. Imaging 4, 558-565 (2011).

  • van den Broek NM, Ciapaite J, De Feyter HM, Houten SM, Wanders RJ, Jeneson JA, Nicolay K, and Prompers JJ. Increased mitochondrial content rescues in vivo muscle oxidative capacity in long-term high-fat-diet-fed rats. FASEB J. 24, 1354-1364 (2010).

  • Jeneson JA, Schmitz JP, van den Broek NM, van Riel NA, Hilbers PA, Nicolay K, and Prompers JJ. Magnitude and control of mitochondrial sensitivity to ADP. Am. J. Physiol. Endocrinol. Metab. 297, E774-E784 (2009).

  • De Feyter HM, Lenaers E, Houten SM, Schrauwen P, Hesselink MK, Wanders RJ, Nicolay K, and Prompers JJ. Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxidative capacity throughout the pathogenesis of type 2 diabetes. A longitudinal in vivo 1H and 31P MRS study in the Zucker Diabetic Fatty rat. FASEB J. 22, 3947-3955 (2008).

  • De Feyter HM, van den Broek NM, Praet SF, Nicolay K, van Loon LJ, and Prompers JJ. Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction. Eur. J. Endocrinol. 158, 643-653 (2008).

  • De Feyter HM, Praet SF, van den Broek NM, Kuipers H, Stehouwer CD, Nicolay K, Prompers JJ, and van Loon LJ. Exercise training improves glycemic control in long-standing, insulin-treated type 2 diabetes patients. Diabetes Care 30, 2511-2513 (2007).

  • van den Broek NM, De Feyter HM, de Graaf L, Nicolay K, and Prompers JJ. Intersubject differences in the effect of acidosis on phosphocreatine recovery kinetics in muscle after exercise are due to differences in proton efflux rates. Am. J. Physiol. Cell Physiol. 293, C228-C237 (2007).

Membership in scientific bodies/juries

  • Member of the International Society for Magnetic Resonance in Medicine (ISMRM)

  • Member of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB)

  • Member of the European Association for the Study of Diabetes (EASD)

  • Member of the American Physiological Society (APS)


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