Short CV/Education and training

  • 1990
    Graduation High school 'Jerusalem', Venray, The Netherlands

  • 1991
    Bachelor's Degree Biomedical Sciences (Cum Laude), Leiden University

  • 1992
    Bachelor's Degree Medicine, Leiden University

  • 1994
    Fellowship "Genetic alterations in thyroid tumours". Department of Clinical Genetics, Karolinska Institute, Stockholm, Sweden; Supervisors: Dr. J. Zedenius, Dr. C. Larsson, Dr. P. Devilee

  • 1994 – 1995
    Fellowship "Genetic alterations in bone tumours" Department of Pathology, Leiden University; Supervisor: Prof. Dr. P.C.W. Hogendoorn

  • 1995
    Master's Degree Medicine, Leiden University

  • 1997
    Medical Degree, Leiden University

  • 1997 – 1998
    PhD student on project 'A Molecular genetic characterisation of cartilaginous tumours' Department of Pathology, Leiden University Supervisor: Prof. Dr. P.C.W. Hogendoorn

  • 1998 – 2003
    Resident in Surgical Pathology, Department of Pathology, Leiden University Head: Prof. Dr. G.J. Fleuren

  • 2000
    PhD in Medicine (Cum Laude), Leiden University, Leiden, The Netherlands

  • 2002
    Fellowship "Oncological surgical pathology" (including soft tissue tumours (Prof. C.D.M. Fletcher), breast pathology (Dr. S. Lester), haematopathology (Dr. G. Pinkus) and dermatopathology (Dr. Ph. McKee and Dr. S. Granter)); Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, U.S.A; Supervisor: Prof. C.D.M. Fletcher.

  • 2011
    Fellowship "Soft tissue tumours" Prof. C.D.M. Fletcher and Prof. J.A. Fletcher, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, U.S.A

Selected publications

  • Pansuriya TC, van Eijk R, d? Adamo P, Kuijjer ML, van Ruler MAJH, Oosting J, Cleton-Jansen AM, van Oosterwijk JG, Verbeke SLJ, Meijer D, van Wezel T, Nord KH, Sangiorgi L, Toker B, Liegl-Atzwanger B, San-Julian M, Sciot R, Limaye N, Kindblom LG, Daugaard S, Godfraind C, Boon LM, Vikkula M , Kurek KC, Szuhai K, French PJ, Bovée JVMG. Somatic mosaic IDH1 or IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome. Nature Genetics 2011: 43(12);1256-61

  • Bovée JVMG, Hogendoorn PCW, Wunder JS, Alman BA. Cartilage tumors and bone development: molecular pathology and possible therapeutic targets. Nat Rev Cancer 2010; 10(7):481-8

  • Bovée JVMG. EXTra hit for mouse osteochondroma. Proc Natl Acad Science USA 2010: 107(5):1813-1814

  • Schrage YM, Briaire-de Bruijn IH, de Miranda NFCC, van Oosterwijk J, Taminiau AHM, van Wezel T, Hogendoorn PCW, and Bovée JVMG. Kinome profiling of chondrosarcoma reveals Src-pathway activity and dasatinib as option for treatment. Cancer Res 2009: 69(15):6216-22

  • Bovée JVMG, Cleton-Jansen AM, Taminiau AHM and Hogendoorn PCW. Emerging pathways in the development of chondrosarcoma of bone and implications for targeted treatment. Lancet Oncol 2005; 6: 599?607



Complete list of publications

Selected projects

  • "A 'bedside to bench' investigational platform for the study of myxoid liposarcoma"; $80.000,- (total grant $250.000) Liddy Shriver Sarcoma Initiative 2012-2014

    PI: T. Nielsen (Vancouver, Canada)

    Other projectleaders: JVMG Bovée, A. Lazar and D. Lev (Houston, USA).

  • Participation in EuroSarc consortium. Seventh Framework, collaborative project, theme Health ("Investigator-driven treatment trials for rare cancers") 2012-2017 Full title: "European Clinical trials in Rare Sarcomas within an integrated translational trial network". Grant number 278742. Work-package leader WP2 "Molecular diagnosis and translational research" and member of executive committee (taken over from PCW Hogendoorn per 01/03/2012). €647.000 (Total grant €5.953.832,00) Coordinator: J.Y. Blay.

  • "Identification and validation of novel kinase drug targets for sarcoma growth and therapy resistance". Leiden University, Research Profile "Translational drug discovery and development" (PhD student)

    PI: Danen E

    Other projectleaders: Bovée JVMG, van de Water B, Hogendoorn PCW

  • "Reverting chemo- and radioresistance mechanisms in chondrosarcoma: targeting anti-apoptotic machinery components and pro-survival signaling pathways" €286.400,- (PhD student and bench fee)

    Dutch Cancer Society / Koningin Wilhelmina Fonds UL 2010-4873

    2011-2015

    PI: Bovée JVMG

    Other projectleaders: van de Water B., Karperien M.

  • "Deep exome sequencing to identify the gene causing solitary and Ollier chondrosarcomas" $50.000,- (bench fee) Liddy Shriver sarcoma initiative 2011-2012.

    PI: Bovée JVMG

    Other projectleader: Oosting J.

  • "Estrogen signalling as a target for chondrosarcoma treatment" €232.500,- (post-doc and technician) Dutch Cancer Society / Koningin Wilhelmina Fonds UL 2007-3815. 2007-2009.

    PI: Bovée JVMG

    Other projectleaders: Karperien M, Hogendoorn PCW.

  • Aspasia grant Netherlands Organization for Scientific Research (NWO) €100.000,- (PhD student 2 years) 2007-2012.

    PI: Bovée JVMG

  • "Bridging the gap between normal and neoplastic cartilage regulation" €600.000,- (PhD student, post-doc and technician) 917.76.315

    ZON-MW / Netherlands Organization for Scientific Research. VIDI-program 2006-2011.

    PI: Bovée JVMG

  • "Primary vascular tumours of bone; towards a new classification based on pathology and genetics". Research year for residents (Verbeke SLJ). €72.000,-. Dutch Cancer Society / Koningin Wilhelmina Fonds 2006

    PI: Bovée JVMG

    Other projectleader: Hogendoorn PCW

  • Participation in EuroBoNet consortium (www.eurobonet.eu). Sixth Framework, Networks of Excellence, "Uncommon Cancers in Adults and Children"

    2006-2011. LSHCCT- 2006-018814 Total grant €15.000.000.

    Work-package leader WP1.1 "Biology of central and peripheral chondrosarcoma" € 445.567,- (PhD student and bench fee)

  • "Expression profiling of peripheral chondrosarcoma progression: towards molecular understanding for diagnostic tools." € 414.783,- (PhD student, technician, bench fee). Dutch Cancer Society, Koningin Wilhelmina Fonds.

    2002-2006. UL 2002-2738

    PI: Hogendoorn PCW, Bovée JVMG

    Other projectleader: Cleton-Jansen AM.

  • "Characterization of the pathways in the evolvement of central chondrosarcoma of bone." €170.720,- (PhD student and bench fee).

    ZON-MW / Netherlands Organization for Scientific Research.

    2002-2006.

    PI : Bovée JVMG

Membership in scientific bodies/juries

  • Member scientific advisory board patientorganization "sarcoma.nl", since 2012

  • Member of evaluation committee Rubicon Life Sciences 2011 – 2013, NWO

  • Faculty Member Faculty of 1000 (F1000) post-publication peer review, since 2012

  • Associate Faculty Member Faculty of 1000 (F1000) post-publication peer review, 2010 – 2012

  • Editor "clinical sarcoma research", since 2010

  • Senior editor "International Journal of Clinical and Experimental Pathology", since 2010

  • Member Clinical Scientific Research ("Klinisch Wetenschappelijk Onderzoek") Committee, ZON-MW, since 2009

  • Editorial board member "Atlas of Genetics and Cytogenetics in Oncology and Haematology", solid tumours section, since 2007

  • Board member of "European Musculoskeletal Oncology Society" (EMSOS), since 2007

  • Member of scientific advisory board of Dutch Multiple Osteochondromas patient organization, since 2003

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