Short CV/Education and training

  • Since 2013
    Director Alliances, Business Development, Molecular Partners AG, Zurich, Switzerland

  • 2008 – 2013
    Senior Project Leader, Molecular Partners AG, Management of the pre-clinical development of the programme MPO112 – an anti-VEGF DARPin. Application for Phase I/IIa of the clinical studies in the USA and Europe, Head of the project MPO112: clinical development in ophthalmology, Zurich, Switzerland

  • 2007 – 2008
    Director Project Management, Vivendy Therapeutics, Management of the Morbus Morquio project focusing on preclinical research and development, proof-of-concept and process developments. Time planning, milestones, and responsibility for the budget. Report to the CEO, Support from Vivendy's closing of Series A, funding of ca. CHF 17 million, Zurich, Switzerland

  • 2002 – 2007
    Head Antibody Development, preclinical section. Research & development for the therapeutic antibody programme MT203. Research, lead identification and optimisation up to preclinical characterisation, proof-of-concept and formal toxicological studies of MT203, Micromet AG, Munich, Germany

Education

  •  
    Postdoc in the biochemistry section, University of Zurich, Switzerland, Research project: "Generation of scFv Antibody Fragments Stabilising G Protein-coupled Receptors"

  •  
    PhD at the MRC Centre for Protein Engineering, University of Cambridge, and Gonville and Caius College, Cambridge, UK, 2000

  •  
    Master's degree at the Department of Molecular Genetics, University of Göttingen, Germany

Selected publications

  • Krinner, E.M. et al.: Fully Human Monoclonal IgG1 Potently Neutralizing the Proinflammatory Cytokine GM-CSF. In: Mol. Immunol. 44, 2007. pp. 916-925.

  • Plater-Zyberk, C. et al.: GM-CSF Neutralization Suppresses Inflammation and Protects Cartilage in Acute Streptococcal Cell Wall Arthritis of Mice. In: Ann Rheum Dis., Oct. 4, Epub ahead of print, 2006.

  • Krinner, E. et al.: A Highly Stable Polyethylene Glycol-conjugated Human Single-Chain Antibody Neutralizing Granulocyte Macrophage Colony stimulating Factor at Low Nanomolar Concentration. In: Protein Eng. Des. Sel. 19, 2006. pp. 461-470.

  • Henckel, J., Plückthun, A.: Directed Evolution and Selection: In Vivo and in Vitro Systems. Screening 1, 2001. pp. 20-22.

  • Nikolova, P.N. et al.: Mechanism of Restoring Function to Common p53 Cancer Mutations by Second-site Suppressor Mutants. In: EMBO J. 19, 1999. pp. 101-109.

  • Durocher, D. et al.: The FHA Domain Is a Modular Phosphopeptide Recognition Motif. In: Mol. Cell 4, 1999. pp. 387-394.

  • Henckel, J., Bullock, A.N., Fersht, A.R.: Stability and Function of the DNA-binding Domain of Human p53. In: Biol. Chem. 379, 1998. p. 76.

  • Nikolova, P.N. et al.: Semirational Design of Active Tumor Suppressor p53 DNA Binding Domain with Enhanced Stability. In: Proc. Nat. Acad. Sci. USA 95, 1998. pp. 14675-14680.

  • Bullock, A.N. et al.: Thermodynamic Stability of Wild-Type and Mutant p53 Core Domain. In: Proc. Nat. Acad. Sci. USA 94, 1997. pp. 14338-14342.

  • Bullock, A.N., Henckel, J., Fersht, A.R.: Quantitative Analysis of Residual Folding and DNAbinding in Mutant p53 Core Domain: Definition of Mutant States for Rescue in Cancer Therapy. In: Oncogene 19, 2000. pp. 1245-1256.


Selected projects

Patents:

  • WO2005105844: Preparation of ScFv Antibody Fragments. Inventors: Raum, T.; Henckel, J.; Krinner, E.; Mittelstrass, S.; Wolf, A.

  • WO2006111353: Antibody neutralizers of human granulocyte macrophage colony stimulating factor. Inventors: Raum, T.; Hepp née Henckel, J.; Krinner, E.; Petch née Mittelstrass, S.; Zeman, S; Wolf, A.; Bruckmaier, S.

  • WO2006087178: Use of activated polymers for separation of protein and polypeptide multimers. Inventors: Wolf, A.; Hoffmann, P.; Hepp née Henckel, J.; Raum, T.

  • Further patent applications with Vivendy Therapeutics Ltd. are not yet in the public domain.

Membership in scientific bodies/juries

  • Elected member of the Junge Akademie (academy of young scientists) of the Berlin-Brandenburg Academy of Sciences and Humanities (BBAW) and the National Academy of Sciences Leopoldina

Additional qualifications


Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Mother of two children


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