Short CV/Education and training

  • 1992 – 1994
    Lewes Tertiary College; "A" Level Exams: 3 grade A (Biology, Chemistry, Mathematics); Special Level Exam: Chemistry Distinction; BTEC Units: 3 Distinctions (Biochemistry, Cell Biology, Chemistry)

  • 1993
    Ciba-Geigy Pharmaceuticals, Horsham, Sussex; Work experience student in the Thrombosis Research Department

  • 1994 – 1998
    University of Bath, School of Biological Sciences; Degree: First Class Hon. BSc in Biochemistry

  • 1996
    April – Sept., Karolinska Institute, Huddinge, Sweden; Undergraduate placement student, working on the effects of neonatal nicotine exposure on adult rat brain

  • 1997
    April – Sept., Chiron Corporation, California, USA; Undergraduate placement student, working on kinase inhibitors with the view to potential anti-diabetes drug development

  • 1998 – 2002
    National Institute for Medical Research (affiliated to UCL), PhD student, working on the retroviral restriction factor, Fv1; Degree: PhD in Virology (awarded 2001)

  • 2002 – 2004
    King's College London; Postdoctoral research associate, working on HIV-1 and the APOBEC family of cellular anti-viral factors

  • 2004 – 2008
    King's College London; Royal Society Dorothy Hodgkin Fellow, working on HIV-1 and the APOBEC family of cellular anti-viral factors;

  • 2008 – 2014
    National Institute for Medical Research; Programme Leader (Track) and Wellcome Trust Fellow, working on aspects of retroviral replication

  • Since 2015
    The Francis Crick Institute; Group Leader, working on aspects of retroviral replication

Selected publications

  • Schwefel D, Boucherit VC, Christodoulou E, Walker PA, Stoye JP, Bishop KN* and Taylor IA*. (2015). Molecular determinants for recognition of divergent SAMHD1 proteins by the lentiviral accessory protein Vpx. Cell Host & Microbe. 17:489-499. (*joint senior authors)

  • Wight DJ, Boucherit VC, Wanaguru M, Elis E, Hirst EM, Li W, Ehrlich M, Bacharach E and Bishop KN. (2014). The N-Terminus of Murine Leukaemia Virus p12 Protein Is Required for Mature Core Stability. PLoS Pathog. 10(10):e1004474.

  • Schwefel D, Groom HC, Boucherit VC, Christodoulou E, Walker PA, Stoye JP, Bishop KN, and Taylor IA. (2014). Structural basis of lentiviral subversion of a cellular protein degradation pathway. Nature. 505(7482):234-8

  • Wight DJ, Boucherit VC, Nader M, Allen DJ, Taylor IA and Bishop KN. (2012). The Gammaretroviral p12 protein has multiple domains that function during the early stages of replication. Retrovirology. Oct 4;9:83.

  • Groom HC, Yap MW, Galão RP, Neil SJ, Bishop KN. (2010). Susceptibility of xenotropic murine leukemia virus-related virus (XMRV) to retroviral restriction factors. Proc Natl Acad Sci U S A. 107(11):5166-71.

  • Groom HC, Boucherit VC, Makinson K, Randal E, Baptista S, Hagan S, Gow JW, Mattes FM, Breuer J, Kerr JR, Stoye JP and Bishop KN. (2010). Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome. Retrovirology. Feb 15;7:10.

  • Bishop KN, Verma M, Kim E-Y, Wolinsky SM and Malim MH. (2008). APOBEC3G Inhibits Elongation of HIV-1 Reverse Transcripts. PLoS Pathog 4(12): e1000231.

  • Bishop KN, Holmes RK, Sheehy AM, Davidson NO, Cho SJ and Malim MH. (2004). Cytidine deamination of retroviral DNA by diverse APOBEC proteins. Curr Biol. 14(15):1392-6.

  • Bishop KN, Holmes RK, Sheehy AM and Malim MH. (2004). APOBEC-mediated editing of viral RNA. Science. 305(5684):645.

  • Bishop KN*, Harris RS*, Sheehy AM, Craig HM, Petersen-Mahrt SK, Watt IN, Neuberger MS and Malim MH. (2003). DNA deamination mediates innate immunity to retroviral infection. Cell. 113(6):803-9. (*joint first authors)


Selected projects

  • Infection and replication of retroviruses

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