Short CV/Education and training

  • 1993
    Diplom degree thesis, Goethe University Frankfurt. Expression of genes in subtilin biosynthesis and their regulation. Biochemical and molecular biology analysis to characterise the gene products involved in the biosynthesis of the antibiotic subtilin from Bacillus subtilis

  • 1996
    Doctorate, Goethe University Frankfurt. Biosynthesis of the peptide antibiotic nisin produced by the lactic acid bacterium Lactococcus lactis

  • 1996 – 1997
    Research associate / Postdoc, Max Planck Institute of Biochemistry, Martinsried, Germany. Identification of factors for the stability of the tubulin cytoskeleton in the yeast Saccharomyces cerevisiae

  • 1998 – 2000
    Postdoctoral Fellow, The Beatson Institute for Cancer Research, Glasgow, UK. Identification and analysis of the chaperone complex GimC/Prefoldin and characterisation of its function during the biosynthesis of the cytoskeleton components actin and tubulin

  • 2000 – 2007
    Research associate, head of an Emmy Noether junior research group, Max Planck Institute of Biochemistry, Martinsried. Significance of molecular chaperones for the folding of newly synthesised proteins in eukaryotic cytosol

  • 2007 – 2010
    Senior Scientist, Head of Research and Development, Sloning Biotechnology GmbH, Puchheim

  • 2011 – 2015
    Senior Scientist, Discovery Alliances & Technology, MorphoSys AG, Martinsried

  • 2015 – 2018
    Scientific Associate Director, MorphoSys AG, Martinsried

  • Since 2018
    Technology Manager, TUM ForTe, Research and Innovation, Technical University of Munich, München

Selected publications

  • Tiller, T. et al., : A fully synthetic human Fab antibody library based on fixed VH/VL framework pairings with favourable biophysical properties. In: mAbs 5 (3), 2013. pp. 445-70

  • Behrends, C. et al.: Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers. In: Mol. Cell 23, 2006. pp. 887-897.

  • Siegers, K. et al.: Structure and Function of GimC/Prefoldin. In: Protein Folding Handbook. Part II, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, 2005.

  • Young, J.C. et al.: Pathways of chaperone mediated protein folding in the cytosol. In: Nature Reviews Mol. Cell Biol. 5, 2004. pp. 781-791.

  • Schaffar, G. et al.: Cellular toxicity of polyglutamine expansion proteins: Mechanism of transcription factor dectivation. In: Mol. Cell. 15, 2004. pp. 95-105.

  • Sondermann, H. et al.: Prediction of novel Bag-1 homologs based on structure/function analysis identifies Snl1p as an Hsp70 co-chaperone in Saccharomyces cerevisiae. In: J. Biol. Chem. 277, 2002. pp. 33220-33227.

  • Siegers, K., Schiebel, E.: Purification of GimC from Saccharomyces cerevisiae. In: Chaperonin Protocols, Methods in Molecular Biology 140, 2000. pp. 185-193. Humana Press, Inc., Totowa NJ, USA.

  • Leroux, M. et al.: MtGimC, a novel archaeal chaperone related to the eukaryotic chaperonin cofactor GimC/prefoldin. In: EMBO J. 18, 1999. pp. 6730-6743.

  • Siegers, K. et al.: Compartmentation of protein folding in vivo: sequestration of non-native polypeptide by the chaperonin-GimC system. In: EMBO J. 18, 1999. pp. 75-84.

  • Geißler, S. et al.: A novel protein complex promoting formation of functional alpha- and beta-tubulin. In: EMBO J. 17, 1998. pp. 952-966.

  • Siegers, K. et al.: Biosynthesis of nisin: posttranslational modification of its prepeptide occurs at a multimeric membrane associated lanthionine synthetase complex. In: J. Biol. Chem. 271, 1996. pp. 12294-12301.


Additional qualifications

  • Continuing education in biological safety for project directors and representatives

  • Seminar: Process safety at the BayTech Academy


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