Short CV/Education and training

  • 2002 – 2006
    PhD, School of Physics and Astronomy, University of Edinburgh, UK

  • 2005 – 2008
    Postdoctoral Research Associate, Biological Sciences, Columbia University, USA

  • 2009 – 2010
    Lecturer in Biophysics, School of Physics & Astronomy, University of Leeds, UK

  • 2010 – 2015
    European Research Council Fellow, School of Physics & Astronomy, University of Leeds, UK

  • Since 2013
    Associate Professor Physics, School of Physics & Astronomy, University of Leeds, UK

Selected publications

  • T. Hoffmann, K.M. Tych, M.L. Hughes, D.J. Brockwell and L. Dougan, Towards design principles for determining the mechanical stability of proteins, Physical Chemistry Chemical Physics (2013)

  • K.M. Tych, T. Hoffmann, D.J. Brockwell and L. Dougan, Single molecule force spectroscopy reveals the temperature-dependent robustness and malleability of a hyperthermophilic protein, Soft Matter, 9(37), 9016-9025 (2013) 

  • J.J. Towey, A.K. Soper and L. Dougan, What happens to the structure of water in cryoprotectant solutions?, Faraday Discussions, DOI: 10.1039/C3FD00084B (2013) 

  • T. Hoffmann, K.M. Tych, D.J. Brockwell and L. Dougan, Single molecule force spectroscopy identifies a small cold shock protein as being mechanically robust, Journal of Physical Chemistry B, 117(6):1819-26 (2013) 

  • N.H. Rhys and L. Dougan, The emerging role of hydrogen bonds in polyglutamine structure, stability and association, Soft Matter, 9, 2359-2364 (2013) 

  • J.J. Towey, A.K. Soper and L. Dougan, Molecular insight into the hydrogen bonding and micro-segregation of a cryoprotectant molecule, Journal of Physical Chemistry B, 116(47) 13898 (2012) 

  • N. H. Rhys, A.K. Soper and L. Dougan, The hydrogen bonding ability of the amino acid glutamine revealed by neutron diffraction experiments, Journal of Physical Chemistry B, 116(45) 13308 (2012) 

  • L. Dougan, Measuring molecular forces, Physics Review, 22, 6 (2012)

  • T. Hoffmann and L. Dougan, Single molecule force spectroscopy using polyproteins, ChemSocRev, 41, 4781 (2012) 

  • K. Tych and L. Dougan, A single molecule approach to explore the role of the solvent environment in protein folding, in Proteins in solution and at interfaces: Methods and applications in biotechnology and materials science, Wiley Series on surface and interfacial chemistry, ISBN:9780470952511 (2012)

  • J. Towey and L. Dougan, Structural examination of the impact of glycerol on water structure, Journal of Physical Chemistry B, 116, 1633 (2012) 

  • J. Towey, A.K. Soper and L. Dougan, Preference for isolated water molecules in a concentrated glycerol-water mixture, Journal of Physical Chemistry B, 115, 7799 (2011) 

  • J. Towey, A.K. Soper and L. Dougan, The structure of glycerol in the liquid state: a neutron diffraction study, Physical Chemistry Chemical Physics, 12, 9397 (2011) 

  • L. Dougan, J. Crain, J.L. Finney and A.K. Soper, Molecular Self-assembly in a model amphiphile system, Physical Chemistry Chemical Physics, 12, 10221 (2010) 

  • J.M. Fernandez, S. Garcia-Manyes, L. Dougan, Force-clamp spectroscopy of single proteins, in Single Molecule Spectroscopy in Chemistry, Physics and Biology: Nobel Symposium, Edited by A. Gräslund, R. Rigler and J. Widengren (Springer Series in Chemical Physics) (2010)



Complete list of publications

Selected projects

  • Life in extreme environments

  • Self-assembly of biological molecules and synthetic systems

  • Cryopreservation

  • Protein aggregation

  • Mechanical properites of molecular motors

  • Neutron diffraction of water and aqueous solutions

  • Single molecule force spectroscopy

Membership in scientific bodies/juries

  • Institute of Physics

  • European Molecular Liquids group

  • Biochemical Society

  • Biophysical Society

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