Short CV/Education and training

  • 1989 – 1995
    Bachelor and Masters Medical Biology, Utrecht University. Major: Immunology. Subsidiary subjects: Pathology and General Health Care

  • 1995 – 1999
    Ph.D. student at Department of Immunology, University Medical Center Utrecht, The Netherlands. Subject: Characterization of human IgA Fc receptors.

  • 1996
    October – December: Research period in Laboratory van Dr. L. Pfefferkorn, Dartmouth Medical School, Dartmouth University, U.S.

  • 1999 – 2000
    Post-Doc at Medarex Europe. Subject: FcalphaRI as trigger molecule for antibody therapy of cancer.

  • 2000 – 2002
    Post-Doc at Department of Surgical Oncology, VU University Medical Center (VUMC), Amsterdam, The Netherlands. Detached at Department of Molecular Cell Biology and Immunology. Subject: "Immunotherapy of cancer".

  • 2002 – 2005
    Senior Scientist (tenure) at Department of Surgical Oncology, VU University Medical Center (VUMC), Amsterdam, The Netherlands Detached at Department of Molecular Cell Biology and Immunology.

  • 2005 – 2008
    Assistant Professor at Department of Surgical Oncology, VU University Medical Center (VUMC), Amsterdam, The Netherlands Detached at Department of Molecular Cell Biology and Immunology.

  • since 2008
    Associate Professor at Department of Surgery, and Principle Investigator at the Department of Molecular Cell Biology and Immunology. VU University Medical Center (VUMC), Amsterdam, The Netherlands. Field: Inflammation and Cancer

Selected publications

  • van der Steen LP, Bakema JE, Sesarman A, Florea F, Tuk CW, Kirtschig G, Hage JJ, Sitaru C, van Egmond M. Blocking Fc{alpha}RI on granulocytes prevents tissue damage induced by immunoglobulin A autoantibodies. J. Immunol, 2012;189:1594-601

  • Zhao X, van Beek EM, Schornagel K, van der Maaden H, van Houdt M, Otten MA, Finetti P, van Egmond M, Matozaki T, Kraal G, Birnbaum D, van Elsas A, Kuijpers TW, Bertucci F. van den Berg TK. CD47-SIRPa interactions form a barrier for antibody mediated tumor cell destruction. Proc Natl Acad Sci U S A, 2011, Oct 31.

  • Bakema JE, van Egmond M. The human immunoglobulin A Fc receptor Fc{alpha}RI; a multifaceted regulator of mucosal immunity. Mucosal Immunology, 2011;4(6):612-24.

  • Bakema JE, Ganzevles SH, Fluitsma DM, Schilham MW, Beelen RH, Valerius T, Lohse S, Glennie MJ, Medema JP, van Egmond M. Targeting Fc{alpha}RI on Polymorphonuclear Cells Induces Tumor Cell Killing through Autophagy. J Immunol. 2011;187(2):726-32.

  • Gül N, Bögels M, Grewal S, van der Meer AJ, Rojas LB, Fluitsma DM, van den Tol MP, Hoeben KA, van Marle J, de Vries HE, Beelen RH, van Egmond M. Surgery-induced reactive oxygen species enhance colon carcinoma cell binding by disrupting the liver endothelial cell lining. Gut. 2011;60(8):1076-86.

  • Bakema JE, van Egmond M. Immunoglobulin A: A next generation of therapeutic antibodies? MAbs. 2011;3(4):352-61.

  • van der Bij GJ, Bögels M, Otten MA, Oosterling SJ, Kuppen PJ, Meijer S, Beelen RH, van Egmond M. Experimentally induced liver metastases from colorectal cancer can be prevented by mononuclear phagocyte-mediated monoclonal antibody therapy. J Hepatol. 2010 Oct;53(4):677-85.

  • van der Steen L, Tuk CW, Bakema JE, Kooij G, Reijerkerk A, Vidarsson G, Bouma G, Kraal G, de Vries HE, Beelen RH, van Egmond M. Immunoglobulin A: Fc{alpha}RI Interactions Induce Neutrophil Migration Through Release of Leukotriene B4. Gastroenterology. 2009;137(6):2018-29.

  • van der Bij GJ, Oosterling SJ, Bögels M, Bhoelan F, Fluitsma DM, Beelen RH, Meijer S, van Egmond M. Blocking alpha2 integrins on rat CC531s colon carcinoma cells prevents operation-induced augmentation of liver metastases outgrowth. Hepatology. 2008; 47(2):532-43.

  • van Egmond M. Neutrophils in antibody-based immunotherapy of cancer. Expert Opin Biol Ther. 2008 8(1):83-94.


Selected projects

  • Alberta Cancer high risk for high return funding application: Visualizing and killing metastases in liver (in collaboration with Prof. P Kubes), 2011

  • Dutch Cancer Foundation: Surgical removal of primary colorectal cancer: a double-edged sword?, 2011

  • MaagLeverDarm Foundation: The neutrophil IgA Fc receptor (Fc{alpha}RI) perpetuates chronic inflammation and tissue damage in ulcerative colitis, 2011

  • AgentschapNL: Novel Antibody-Based Therapy for Ulcerative Colitis, 2010

  • LSCA Validation Fund: Increasing Therapeutic Efficacy of IgG?s in Melanoma, 2010

  • NWO Aspasia, 2008

  • Senternovem Immune Therapy for Chronic Inflammatory Diseases (IMMUBLOCK), 2007

  • NWO VIDI: Role of neutrophil immunoglobulin A Fc receptor (Fc{alpha}RI) in mucosal homeostasis and inflammation of the gastro-intestinal tract, 2007

  • NWO VENI: Recruitment of neutrophils in cancer therapy, 2003

Membership in scientific bodies/juries

  • Member of the Dutch Society for Immunology.

  • Member of the American Association of Immunology.

National activities

  • Reviewer for Netherlands Organization for Scientific research (NWO) and Dutch Cancer Society.

  • Member of 6 thesis committees.

  • Supervisor PhD students (6 finished, 7 ongoing).

International activities

  • Referee for international scientific journals including Gastroenterology, Kidney International, Journal of Immunology, Journal of Hepatology, Cancer research, Mucosal Immunology and Blood.

  • Reviewer grants Grant Cancer Research UK, European Union (FP-7, Marie Curie).

  • Participant in the Women and Diversity Speaker List project of the Society for Leukocyte Biology.

  • Consultant on IgA-related topics for several companies

Other academic activities

  • Invited speaker national/ international conferences/universities (> 45)

  • Co-organizer and/ or chair several national/ international meetings

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