Short CV/Education and training

  • 1972 – 1976
    Undergraduate studies, University of Zürich, Switzerland

  • 1976
    Diploma in Zoology and Molecular Biology, University of Zürich, Switzerland

  • 1976 – 1981
    PhD Thesis Zoological Institute, University of Zürich, Switzerland

  • 1981 – 1986
    Postdoctoral research, MRC Laboratory of Molecular Biology, Cambridge, England

  • 1986
    Assistant Professor, Zoological Institute, University of Zürich, Switzerland

  • 1990
    Promoted to Associate Professor

  • 1991
    Senior Staff Member, MRC Laboratory of Molecular Biology, Cambridge, England

  • 1994
    Promoted to Special Appointment

  • 2007
    Joint Head of Cell Biology Division

  • 2008
    Joint Head of Protein & Nucleic Acid Chemistry Division

Selected publications

  • Mieszczanek J, de la Roche M & Bienz M (2008) A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription. Proc Natl Acad Sci USA 105, 19324-19329.

  • Metcalfe C, Mendoza-Topaz C, Mieszczanek J & Bienz M (2010) Stability elements in the LRP6 cytoplasmic tail confer efficient signaling upon DIX-dependent polymerisation. J Cell Sci 123, 1588-1599.

  • Metcalfe C, Ibrahim AEK, Graeb M, de la Roche M, Schwarz-Romond T, Fiedler M, Winton DJ, Corfield A & Bienz M (2010) Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer. Cancer Res 70, 6629-6638.

  • Miller TCR, Rutherford TJ, Johnson CM, Fiedler M & Bienz M (2010) Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor. J Mol Biol 401, 969-984.

  • Fiedler M, Mendoza-Topaz C, Rutherford TJ, Mieszczanek J & Bienz M (2011) Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating beta-catenin. Proc Natl Acad Sci USA 108, 1937-1942.

  • Metcalfe C & Bienz M (2011) Inhibition of GSK3 by Wnt signaling – two contrasting models. J Cell Sci 124, 3537-3544.

  • Mendoza-Topaz C, Mieszczanek J & Bienz M (2011) The Adenomatous polyposis coli tumour suppressor is essential for Axin complex assembly and function and opposes Axin’s interaction with Dishevelled. Open Biol 1, 110013.

  • Licchesi JDF, Mieszczanek J, Mevissen TE, Rutherford TJ, Akutsu M, Virdee S, Oualid FE, Chin JW, Ovaa H, Bienz M & Komander D (2011) An Ankyrin-repeat ubiquitin-binding domain determines TRABID’s specificity for atypical ubiquitin chains. Nature Struct Mol Biol 19, 62-71.

  • de la Roche M, Rutherford TJ, Gupta D, Veprintsev DB, Saxty B, Freund SM & Bienz M (2012) An intrinsically labile alpha-helix abutting the BCL9-binding site of beta-catenin is required for its inhibition by carnosic acid. Nature Commun 3, 680.

  • Miller TCR, Mieszczanek J, Sánchez-Barrena MJ, Rutherford TJ, Fiedler M & Bienz M (2013) Evolutionary adaptation of the fly Pygo PHD finger towards recognizing histone H3 tail methylated at arginine 2. Structure 21, 2208-2220.

  • de la Roche M, Ibrahim AEK, Mieszczanek J & Bienz M (2014) LEF1 and B9L shield beta-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors. Cancer Res, in press.


Membership in scientific bodies/juries

Committees, Panels:

  • Elected to EMBO Council (1994; served on Council 1995 – 2000)

  • Chair of EMBO Membership and Publications Committee (1996 – 2001)

  • MRC Advisory Board (1997 – 1999)

  • MRC Molecular and Medicine Board (1999 – 2003)

  • MRC Cross Board (2002 – 2004)

  • Elected to the Council of the Royal Society (2004; served on Council 2004 – 2006)

  • Chair of Royal Society Partnership Grants Committee (2007 – 2010)

  • CR-UK Clinical Fellowship Selection Panel (2010 – 2012)

  • Royal Society Summer Science Exhibition Committee (2011 – 2013)

  • European Research Council Starting Grant Panel LS3 (since 2012)

  • Royal Society Dorothy Hodgkin Fellowship Panel (since 2014)

  • Chair of Ethical Review Committee of Animal Research at LMB (2000 – 2003)

  • Director of Studies at LMB (2003 – 2006)

  • Adjunct Faculty Member, Cancer Research UK Cambridge Research Institute (since 2011)

Editorial Boards:

  • EMBO Journal (1991 – 1993; 1995 – 1997; 1999 – 2004)

  • Mechanisms of Development (1990 – 2010)

  • Development (1998 – 2003)

  • EMBO Reports (2000 – 2004)

  • Genes & Development (since 2001)

  • Trends in Biochemical Sciences (since 2001)

  • Molecular Cancer (since 2010)

  • Faculty of 1000 Biology (since 2001)

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News

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    Mariann Bienz investigates the mechanisms behind the signalling pathways that switch on gene transcription and how their dysfunction can ultimately cause cancer.