Short CV/Education and training

  • 1986 – 1990
    B.S. in Biology – School of Science, Dept. of Biology, University of Athens, Greece

  • 1991 – 1998
    Ph.D. in Cellular Immunology/Immunogenetics – Dept. of Pathology, Medical College of Pennsylvania/Hahnemann (Drexel U.), Philadelphia PA, U.S.A.

  • 1989 – 1990
    Diploma thesis research on tissue regeneration

  • 1991 – 1992
    Graduate research on differentiation of brain tumors

  • 1993 – 1998
    Ph.D. thesis research on characterization and genetic regulation of immune responses during persistent retrovirus infection. Mentor: Kenneth J. Blank, Ph.D. Professor of Pathology, Dean of Research, Medical College of Pennsylvania

  • 1995
    Research on the somatic hypermutation of the immunoglobulin genes in the germinal center B cells; in collaboration with Dr. Garnet Kelsoe, Professor of Immunology, University of Maryland

  • 1998 – 2002
    Post-doctoral research on mechanisms of induction and regulation of Th1 immunity and autoimmunity. Mentor: Harvey Cantor, M.D. Professor of Pathology, Head of the Dept. of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Harvard Medical School

  • 1998 – 2002
    Post-doctoral fellowship – Depts. of Pathology and Cancer Immunology & AIDS, Harvard Medical School, Dana-Farber Cancer Institute, Boston MA, U.S.A.

  • 2003 – 2010
    Researcher-Assistant Professor, Principal Investigator, Cellular Immunology Laboratory, Biomedical Research Foundation of the Academy of Athens (BRFAA)

  • Since 2010
    Researcher-Associate Professor, Principal Investigator, Cellular Immunology Laboratory, Biomedical Research Foundation of the Academy of Athens (BRFAA)

Selected publications

  • Aggelakopoulou M, Kourepini E, Paschalidis N, Simoes DC, Kalavrizioti D, Dimisianos N, Papathanasopoulos P, Mouzaki A, Panoutsakopoulou V. 2016. ERβ-dependent direct suppression of human and murine Th17 cells and treatment of established central nervous system autoimmunity by a neurosteroid. The Journal of Immunology, 197(7):2598-609.

  • Aggelakopoulou M, Kourepini E, Paschalidis N, Panoutsakopoulou V. 2016. ERβ in CD4+ T cells is crucial for ligand-mediated suppression of central nervous system autoimmunity. The Journal of Immunology, 196(12):4947-56.

  • Kourepini E, Paschalidis N, Simoes DC, Aggelakopoulou M, Grogan JL, Panoutsakopoulou V. 2016. TIGIT enhances antigen-specific Th2 recall responses and allergic disease. The Journal of Immunology, 196(9):3570-80.

  • Kourepini E, Aggelakopoulou M, Alissafi T, Paschalidis N, Simoes DC, Panoutsakopoulou V. 2014. Osteopontin expression by CD103- dendritic cells drives intestinal inflammation. Proceedings of the National Academy of Sciences USA 111(9):E856-65.

  • Samitas K, Zervas E, Vittorakis S, Semitekolou M, Alissafi T, Bossios A, Gogos H, Economidou E, Lötvall J, Xanthou G, Panoutsakopoulou V*, Gaga M*. 2011. Osteopontin expression and relation to disease severity in human asthma. European Respiratory Journal 37(2):331-41. *equal senior authors

  • Semitekolou M, Alissafi T, Aggelakopoulou M, Kourepini E, Kariyawasam HH, Kay AB, Robinson DS, Lloyd CM, Panoutsakopoulou V*, Xanthou G*. 2009. Activin-A induces regulatory T cells that suppress T helper cell Immune responses and protect from allergic airway disease. Journal of Experimental Medicine 206(8):1769-85. *equal senior authors

  • Xanthou G, Alissafi T, Semitekolou M, Simoes D, Economidou E, Gaga M, Lambrecht BN, Lloyd CM, Panoutsakopoulou V. 2007. Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets. Nature Medicine 13(5): 570-578.

  • Panoutsakopoulou V, Huster KM, McCarty N, Feinberg E, Wang R, Wucherpfennig KW, Cantor H. 2004. Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes. Journal of Clinical Investigation 113:1218-1224.

  • Jansson M, Panoutsakopoulou V, Baker J, Klein L, Cantor H. 2002. Attenuated Experimental Autoimmune Encephalomyelitis in Eta-1/Osteopontin-deficient mice. The Journal of Immunology (Cutting edge) 168:2096-2099.

  • Panoutsakopoulou V, Sanchirico ME, Huster K, Jansson M, Granucci F, Shim DJ, Wuckerpfennig KW, Cantor H. 2001. Analysis of the relationship between viral infection and autoimmune disease. Immunity 15(1):137-147.

  • Panoutsakopoulou V, Cantor H. 2001 On the relationship between viral infection and autoimmune disease. Journal of Autoimmun 16:341-345

  • Wei MC, Zong W-X, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ. 2001. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292:727-730

  • Ashkar S, Weber GF, Panoutsakopoulou V, Sanchirico ME, Jansson M, Zawaideh S, Rittling SR, Denhardt DT, Glimcher MJ, Cantor H. 2000. Eta-1 (Osteopontin): an early component of Type-1 (cell-mediated) immunity. Science 287:860-864.

  • Panoutsakopoulou V, Hunter K, Sieck TG, Blankenhorn EP, Blank KJ. 1999. Genetic regulation of long term nonprogression in E-55+MuLV infection in mice. Journal of Virology 73:9232-9236.

  • Panoutsakopoulou V, Little CS, Sieck TG, Blankenhorn EP, Blank KJ. 1998. Differences in the immune response during the acute phase of E-55+MuLV infection in progressor BALB and long-term nonprogressor C57BL mice. The Journal of Immunology 161:17-26.



Complete list of publications

Selected projects

  • Vily's team at BRFAA demonstrated that Opn is highly expressed in the lungs of asthmatic patients and of mice with allergic airway inflammation and exerts dual and opposing effects on Th2-mediated allergic airway disease. These effects of Opn were mainly mediated by regulation of Th2-suppressing plasmacytoid dendritic cells during primary sensitization and Th2-promoting conventional DCs during recall antigenic challenge. In addition, her team identified activin-A as an inducer of functional T regulatory cells that suppress harmful Th2 (allergic) immune responses. To continue studies on the effects of Opn on the immune system, she was awarded a grant by the European Research Council in 2009.

Membership in scientific bodies/juries

  • American Association of Immunology

    European Academy of Allergy and Clinical Immunology

    European Respiratory Society

    Hellenic Association of Immunologists

    Hellenic Academy of Neuroimmunology

    2010 Scientific expert reviewer to evaluate INSERM research units in France

    2011- Organizing committee member, Summer Schools in Immunology

    2012- Organizing committee member, Hellenic Academy of Neuro-Immunology

Media coverage

  • Commentaries and newspaper articles:

  • http://www.nature.com/nm/journal/v13/n5/full/nm0507-536.html

    Leading Edge: The Complex Effects of Osteopontin Cell 129: 637, May 18, 2007; Editor's choice: Highlights of the recent literature Science 316(5824):517, 27 April 2007; Research Highlight Focus on Cytokines & cytokine therapies, Asthma and allergy: Opposing roles for osteopontin (by Lucy Bird) Nature Reviews Immunology 7, 417 (June 2007)

  • http://www.tovima.gr/science/article/?aid=181816

  • http://www.tovima.gr/society/article/?aid=297277

  • http://jem.rupress.org/content/206/8/1638.3.full

  • TV interview: https://www.youtube.com/watch?v=dR37ohqfe5I

Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Married to Ilias Scotiniotis, M.D.

    Children: Lucas, Antonis, Thanos


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