Short CV/Education and training

  • 1993 – 1999
    BSc and MSc in Medical Biology at Utrecht University

  • 1997 – 1998
    BSc project (6 months) at the department of Metabolic Disorders at the Utrecht University

  • 1998 – 1999
    MSc project (9 months) at the department of Physiological Chemistry at the Utrecht University

  • 1999 – 2004
    PhD student, Department of Pediatric Gastroenterology and department of Metabolic and Endocrine Diseases

  • 2004 – 2005
    Post Doctoral Research Associate, Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom

  • 2005 – 2006
    Marie Curie fellow, Institute of Reproductive and Developmental Biology, Imperial College London, London, United Kingdom

  • Since 2007
    Assistant professor, NWO-VENI laureate, Dept. of Metabolic and Endocrine Diseases, UMC Utrecht, Utrecht, The Netherlands

  • Since 2011
    Associate Professor, NWO-VIDI laureate, Dept. of Metabolic Diseases, UMC Utrecht, Utrecht, The Netherlands

Selected publications

  • Hollman DAA, Milona A, van Erpecum KJ, van Mil SWC. Anti-inflammatory and metabolic actions of FXR: insights into molecular mechanisms. Biochim Biophys Acta. 2012 Nov;1821(11):1443-52.

  • Gadaleta RM, van Erpecum KJ, Oldenburg B, Willemsen EC, Renooij W, Murzilli S, Klomp LW, Siersema PD, Schipper ME, Danese S, Penna G, Laverny G, Adorini L, Moschetta A, van Mil SWC. Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut. 2011 Apr; 60(4):463-72.

  • Gadaleta RM, Oldenburg B, Willemsen EC, Spit M, Murzilli S, Salvatore L, Klomp LWJ, Siersema PD, van Erpecum KJ, van Mil SWC. Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-?B signaling in the intestine. Biochim Biophys Acta. 2011 Aug;1812(8):851-8.

  • Milona A, Owen B, Cobbold J, Cox J, Boudjelal M, Cairns W, Parker MG, White R, van Mil SWC #, and Williamson C#. Hepatic bile acids accumulate during pregnancy as a result of reduced Farnesoid-X-Receptor (FXR) function. # Both authors contributed equally. Hepatology. 2010 Oct;52(4):1341-9.

  • Dixon PH, van Mil SWC, Chambers J, Strautnieks S, Thompson R, Lammert F, Kubitz R, Keitel V, Glantz A, Mattsson LA, Marschall HU, Molokhia M, Moore G, Linton K, Williamson C. Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy. Gut, 2009 58(4):537-44.

  • van Mil SWC, Milona A, Dixon PH, Mullenbach R, Geenes VL, Chambers J, Shevchuk V, Moore GE, Lammert F, Glantz AG, Mattsson LA, Whittaker J, Parker MG, White R, Williamson C. Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy. Gastroenterology, 2007;133(2):507-16

  • van Mil SWC, van der Woerd W, van der Brugge G, Sturm E, Jansen PL, Bull L, van den Berg IET, Berger R, Houwen RHJ, Klomp LWJ. Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11. Gastroenterology, 2004, 127 (2) 379-384.

  • Klomp LWJ, Vargas J, van Mil SWC, Pawlikowska SWC, Strautnieks SS, van Eijk MJT, Juijn JA, Pabón-Peña C, Smith L, Deyoung J, Byrne JA, Gombert J, van der Brugge G, Berger R, Jankowska I, Pawlowska J, Villa E, Knisely AS, Thompson RJ, Freimer NB, Houwen RHJ and Bull LN. Characterization of mutations in atp8b1 associated with hereditary cholestasis. Hepatology, 2004, 40 (1) 27-38.

  • Lykavieris P, van Mil SWC, Cresteil D, Fabre M, Hadchouel M, Klomp LWJ, Bernard O, Jacquemin E. Progressive familial intrahepatic cholestasis type 1 and extrahepatic features: no catch-up of stature growth, exacerbation of diarrhea, and appearance of liver steatosis after liver transplantation. Journal of Hepatology 2003, (39) 447-452.

  • Eppens E*, van Mil SWC*, de Vree M, Mok K, Juijn JA, Oude Elferink R, Berger R, Houwen RHJ, Klomp LWJ. FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte. *Both authors contributed equally. Journal of Hepatology 2001; 35, 436-443.

Complete list of publications

Selected projects

  • My group investigates the role of bile acid homeostasis and the nuclear receptor FXR in diseases of the gastro-intestinal tract. This receptor is activated by bile acids, and regulates transcription of genes involved in the maintenance of bile acid, lipid, and glucose homeostasis. Since bile acids are very toxic, the role of FXR is crucial to keep low bile acid concentrations in the body. We have recently shown that FXR activation protects against intestinal inflammation.

Membership in scientific bodies/juries

Academic activities:

  • Dutch Hepatology Association ( Nederlandse Vereniging voor Hepatologie, Member 2009 – 2013, Board secretary 2013 – 2015; Organization of meetings and symposia

  • Co-organizer of NVH Dutch Liver Retraite, Kasteel Schortinghuis, Spier, The Netherlands, October 2010, 2011, 2012

  • Co-organizer of Dutch Experimental Gastroenterology and Hepatology Meeting, Koningshof, Veldhoven, The Netherlands, March 2010, 2011, 2012

  • Peer reviewer for national and international grant foundations and journals

  • Board member of 'Steyn Parvé Actueel', an UMC Utrecht program for female researchers. I co-organize meetings and symposia. For example, I co-organized a debat on 'What makes a research group succesful? at 8 December 2010, in collaboration with the Rathenau Institute

  • Member of ZonMW VENI grant proposal committee, 2011


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