Short CV/Education and training

  • 1991
    MsSc in Biology, University of Milan, Italy

  • 1991 – 1995
    Ph.D. student, Dipartimento di Genetica e Biologia dei Microorganismi, University of Milan, Italy

  • 1996 – 1999
    Postdoctoral Fellow, Unit of Human Virology, Dibit San Raffaele Hospital, Milan, Italy

  • 1999 – 2002
    Postdoctoral Fellow, European Institute of Oncology, Milan, Italy

  • 2002 – 2005
    Staff scientist at the European Institute of Oncology (IEO), Milan, Italy

  • 2005
    Group Leader at the IFOM,FIRC Institute of Molecular Oncology, Milan, Italy

  • 2006
    Associate Professor, University of Milan, Pathology Department, and European School of Molecular Medicine (SEMM) at IFOM-IEO Campus

  • 2009
    Embo Young Investigator

Selected publications

  • Maspero E, Valentini E, Mari, S, Cecatiello V, Soffientini P, Pasqualato S, Polo S. 2013. Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming. NSMB. Published online 05 May 2013 | doi:10.1038/nsmb.2566

  • Sigismund S, Confalonieri S, Ciliberto A, Polo S, Scita G, and Di Fiore PP. P 2011. Endocytosis: cell logistics shape the eukaryotic cell plan. Physiological Reviews.

  • Maspero E, Mari S, Valentini E, Musacchio A, Fish A, Pasqualato S, Polo S. 2011. Structure of the HECT:Ub complex and its role in ubiquitin chain elongation. EMBO Rep. 12: 342-349

  • Argenzio E, Bange T, Oldrini B, Bianchi F, Peesari R, Mari S, Di Fiore PP, Mann M, and Polo S. 2011. Proteomic snapshot of the EGF-induced ubiquitin network. Mol Syst Biol. 7:462

  • Sigismund, S., E. Argenzio, D. Tosoni, E. Cavallaro, S. Polo*, and P.P. Di Fiore*. 2008. Clathrin-mediated internalization is essential for sustained EGFR signaling but dispensable for degradation. Dev Cell 15:209-219. *co-corrisponding authors

  • Woelk, T., B. Oldrini, E. Maspero, S. Confalonieri, E. Cavallaro, P.P. Di Fiore, and S. Polo. 2006. Molecular mechanisms of coupled monoubiquitination. Nat Cell Biol 8:1246-1254.

  • Polo, S., and P.P. Di Fiore. 2006. Endocytosis conducts the cell signaling orchestra. Cell 124:897-900.

  • Penengo, L., M. Mapelli, A.G. Murachelli, S. Confalonieri, L. Magri, A. Musacchio, P.P. Di Fiore*, S. Polo*, and T.R. Schneider*. 2006. Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. Cell 124:1183-1195. *co-corrisponding authors.

  • Sigismund, S., T. Woelk, C. Puri, E. Maspero, C. Tacchetti, P. Transidico, P.P. Di Fiore, and S. Polo. 2005. Clathrin-independent endocytosis of ubiquitinated cargos. Proc Natl Acad Sci U S A 102:2760-2765.

  • Polo, S., S. Sigismund, M. Faretta, M. Guidi, M.R. Capua, G. Bossi, H. Chen, P. De Camilli, and P.P. Di Fiore. 2002. A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature 416:451-455.


Selected projects

  • to characterize the mechanisms through which signals are transferred from the activated EGF receptor to the ubiquitination machinery

  • to identify the DUBs involved in the EGFR pathway

  • to characterize the molecular mechanisms of E3 ligases (Nedd4 and Cbl)

  • to develop new tools for capturing Ub signaling in vivo

Membership in scientific bodies/juries

  • AICR, association for international cancer research UK, member of the SAC Advisory Committee

Editorial Activities:

  • Ad hoc reviewer for the following journals and agencies:

    Cell, Nature, Nature Cell Biology, Current Biology, Journal of Cell Biology, PNAS, EMBO, EMBO Reports, Oncogene. BSF United States-Israel Binational Science Foundation, AIRC, AICR.

Media coverage

  • Scientific achievements have been reported in several Italian newspapers from 2002 up to now.

Additional qualifications

Faculty Activities:

  • Intramural:

  • In charge of the Pathology course at the University of Milan for the Healthcare Professions. Lecturer in several courses of the SEMM, (http://www.semm.it) the PhD program of the IFOM-IEO campus.

  • Extramural:

  • Graduate course "The ubiquitin-proteasome system in health and disease", Karolinska Institutet, Stockholm, Sweden (September 3-14, 2007). Lecturer

  • EMBO Practical Course on Ubiquitin and Sumo. Split, Croatia (September 12-18, 2008). Co-organizer and Lecturer

  • EMBO Practical Course on Ubiquitin and Sumo. Split, Croatia (29 July – 4 August, 2010). Co-organizer and Lecturer

  • Graduate course "Seminars on the regulation of intracellular protein and lipid traffic", Université de Lausanne, Lausanne, Switzerland (November 5, 2010). Lecturer

  • Graduate course "Membrane traffic in development and disease", Graduate School Cancer Genomics & Developmental Biology (CGDB), University Medical Centre Utrecht (March 8, 2012). Lecturer

  • Graduate course "Endocytosis", Karolinska Institutet, Stockholm, Sweden (April 19-25, 2012). Lecturer

  • 2nd Joint Summer School on Molecular Biology, Udine, Italy (July 9-13, 2012). Lecturer

  • Organizer of the next 2012 EMBO Practical Course on Ubiquitin and Sumo (1-8 September, 2012) Alghero, Italy

Invited Speaker (recent selection):

  • 2010:

  • Rubicon workshop, "Role of various type of ubiquitin chains in membrane trafficking". Paris, May 20-21.

  • 2nd Vesicle Transport and Cancer workshop. Turku, June 7-9.

  • FASEB Conference "Receptor Tyrosine Kinases, Biology and Cancer". Carefree, June 27-July 2.

  • 1st Cellular Networks Conference – CNC2010, Heidelberg. September, 23-26.

  • Banbury Center Meetings, "Signaling Through Ubiquitin". November 14-17.

  • 2011:

  • CSHL "The Ubiquitin Family". Cold Spring Harbour, May 17-21.

  • British Society for Cell Biology Meeting "Cell Biology of Protein Degradation Pathways". Liverpool, September 11-13.

  • EMBO meeting "Membrane Dynamics in Endocytosis". Crete, September 25-29.

  • 2012:

  • FASEB Conference "Ubiquitin & Cellular Regulation", 06/24/2012 Saxtons River, Vermont, June 24-29.

  • 2013:

  • CSHL "The Ubiquitin Family". Cold Spring Harbour, May 17-21.

  • EMBO meeting "Ubiquitin and Ubiquitin-like Proteins: From Structure to Function". Riva del Garda, October 2-5.

Invited Organizer:

  • Keystone Symposium The Many Faces of Ubiquitin. January 11 – 16, Copper Mountain, Colorado, 2009


Soft Skills/Other activities and achievements

Other activities and achievements/family

  • married, two children


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