Short CV/Education and training

  • 1990 – 1994
    Harvard University, Cambridge, MA, USA, B.A. in Biology, Magna Cum Laude

  • 1994 – 1995
    Teaching Assistant: Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA

  • 1994 – 1999
    Ph.D. in Molecular and Cell Biology, University of California, Berkeley, CA, USA

  • 1995 – 1999
    Doctoral Research: Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA, (graduate adviser: Dr. Robert Tjian)

  • 2006 – 2007
    Instructor: Department of Developmental Biology, University of Freiburg, Germany

  • 2000 – 2007
    Postdoctoral Research: Department of Developmental Biology, University of Freiburg, Germany, (in the laboratory of Dr. Wolfgang Driever)

  • since 2008
    Group Leader, Indepedent Junior Research Group: Max Planck Institute for Medical Research, Heidelberg, Germany

Selected publications

  • Ryu, S. et al.: Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development. In: Current Biology 17(10), 2007. S. 873-880.

  • Ryu, S. et al.: Depletion of minichromosome maintenance protein 5 in zebrafish retina causes cell-cycle defect andapoptosis. In: Proc. Natl. Acad. Sci. USA. 102, 2005. S. 18467-18472.

  • Ryu, S. et al.: Transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. In: Nature 397, 1999. S. 446-450.

  • Ryu, S., Tjian, R.: Purification of the transcription cofactor complex CRSP. In: Proc. Natl. Acad. Sci. USA. 96, 1999. S. 7137-7142.


Selected projects

  • Homeostasis is a hallmark of biological systems. To survive, an organism needs to adapt to the demands of the external environment and change its behavioral and physiological responses appropriately. Within the brain, this plasticity is afforded by neural circuits that function robustly in a largely unpredictably environment and can rearrange in ways that allow more efficient responses to future stimuli. The research group ‘Developmental Genetics of the Nervous System’ was established in July 2008 with the long-term goal of understandings the logistics of building neuron types and circuits that can adapt to enviroment. We approach this question by focusing on the development and function of neural circuits in hypothalamus, a key integrative center in the brain that controls immense number of crucial bodily functions such as sleep, reproduction, food intake, and stress response. Our main biological model is the zebrafish, which shares conserved developmental mechanism with mammals, yet contains much fewer neurons making it easier to analyze and manipulate these neurons. Our basic approach is to combine tools available in developmental biology with those available in connectivity and circuit function analysis.

Additional qualifications

  • BA in Arts in Science, Harvard University, USA


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