Short CV/Education and training

  • 1997 – 2002
    University of Kaiserslautern, Germany

  • 2000
    three month studentship at the department of Zoology / Oxford. Role of protein phosphatases in signalling and Drosophila development / Creation of Drosophila melanogaster transgenic lines

  • 2001 – 2002
    Diploma in Biology (grade 1,33). Thesis: 1. Analysis of the replication origin of linear plasmid SCP1 from Streptomyces coelicolor A3(2) Knock out of 2 ORFs in the predicted replication origin with Lambda Red homologous recombination system (?, ? exo). 2. Tn 5 based Transposon mutagenesis of the predicted replication origin and functional classification of Transposon Clones

  • 2002 – 2007
    Bernhard Nocht Institute For Tropical Medicine / Hamburg, research associate (PhD student). Host-pathogen interactions: 1. Analysis of global gene expression in Arenavirus (Lassa and Lymphocytic Choriomeningitis Virus) infected human hepatoma cells using DNA Microarray 2. Analysis of interferon induction in Arenavirus infected human hepatoma cells and primate fibroblast cells with quantitative real time RT-PCR. Virus genetics: 1. Contribution to the construction of an artificial Lassa virus Replicon system and analysis of viral replication mechanisms. Antiviral Therapy and Diagnostics: 1. Design and experimental testing of a therapeutic siRNA directed against Lassa virus, 2. Characterization of the antiviral properties of Zinc finger antiviral protein in Ebola and Marburg virus infection, 3. Contribution to the characterization of the causative agent of severe acute respiratory syndrome (SARS). PhD degree 2.2.2007 Magna cum laude

  • 2007 – 2011
    Universite Louis Pasteur CNRS, Institut de Biologie Moleculaire et Cellulaire /Strasbourg, Research associate (post-doctoral scientist). Analysis of Drosophila innate immune response to viral infection: 1. The DExD/H-box helicase Dicer-2 mediated induction of antiviral activity in Drosophila, specifically the study of the inducible gene expression upon infection with Drosophila C virus, 2. RNA interference in negative-strand virus-infection, specifically the implication of RNA interference in Vesicular stomatitis virus (VSV) infection, 3. Comparative analysis of Drosophila melanogaster immune pathways in infection with ssRNA, dsRNA and DNA viruses, 4. Analysis of miRNA profiles in VSV infected Drosophila and comparison to miRNA profiles in VSV infected mammalian cells (collaboration with Sebastien Pfeffer)

Selected publications

  • Deddouche S, Matt N, Budd A, Mueller S, Kemp C, Galiana-Arnoux D, Dostert C, Antoniewski C, Hoffmann JA, Imler JL. The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in Drosophila. Nat Immunol. 2008 Dec;9(12):1425–3

  • Mueller S., Gausson V., Vodovar N., Deddouche S., Troxler L., Perot J., Pfeffer S., Hoffmann J.A., Saleh M.-C., Imler J-L. RNAi-mediated immunity provides strong protection against the negative-strand RNA vesicular stomatitis virus in Drosophila. PNAS November 9, 2010 vol. 107 no. 45 19390–19395

  • Kemp C, Mueller S, Goto A, Barbier V, Paro S, Bonnay F, Dostert C, Troxler L, Hetru C, Meignin C, Pfeffer S, Hoffmann JA, Imler JL. Broad RNA Interference-Mediated Antiviral Immunity and Virus-Specific Inducible Responses in Drosophila. J Immunol. 2012 Dec 19. [Epub ahead of print] equal contribution


Selected projects

  • We are working on interactions of mosquito-borne viruses with insect vector in the natural vector mosquitoes and the insect model system Drosophila melanogaster. Within this field we 1) analyse the factors necessary for successful colonisation of insects by viruses (receptor usage, gut microbiota); 2) the antiviral immunity of insects which allows mosquitoes to harbour and transmit viruses lifelong and 3) the possibility of lifelong infected vector insects to serve as platform for virus evolution.

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