Short CV/Education and training

  • 1994
    Ph.D, Hungarian Academy of Sciences

  • 1985 – 1991
    Research Assistant, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary

  • 1991
    Affiliation with Biological Research Center of Hungarian Academy of Sciences, Szeged, Hungary

  • 1991 – 1995
    Postdoctoral Associate, U. of Minnesota, USA

  • 1995 – 1997
    Research Associate, U. of Minnesota, USA

  • 1997 – 1999
    EMBO fellow, The Netherlands Cancer Institute, NL

  • 1999 – 2004
    Postdoctoral Scientist, Max Delbrück Center for Molecular Medicine, Berlin, Germany

  • 2004 – 2011
    Group leader – junior, Max Delbrück Center for Molecular Medicine, Berlin, Germany

  • 2009 – 2011
    Guest Professor at the Medical University Debrecen, Hungary

  • since 2011
    Group leader – permanent, Max Delbrück Center for Molecular Medicine, Berlin, Germany

Selected publications

Selected Publications (out of 76) h-index 27, citation 3217

  • Ivics Z, Izsvák Z, Medrano G. Chapman KM, Hamra FK Sleeping Beauty Transposon Mutagenesis in Rat Spermatogonial Stem Cells. 2011; Nature Prot 8;6(10):1521-35

  • Belay E, …, Izsvák Z, Vandendriessche T, Chuah MK, Novel Hyperactive Transposons for Genetic Modification of Induced Puripotent and Adult Stem Cells: A Non-Viral Paradigm for Coaxed Differentiation. 2010; Stem Cells (10):1760-71.

  • Izsvák Z, et al., Generating Knockout Rats by Sleeping Beauty Transposon Mutagenesis in Spermatogonial Stem Cells. 2010; Nature Methods 7(6):443-5.

  • Wang Y, …, Izsvák Z, A Novel Active Endogenous Retrovirus Family Contributes to Genome Variability in Rat Inbred Strains. Genome Research 2010; 20(1):19-27.

  • Mátés L, …, Izsvák Z, Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates. Nature Genet. 2009; 41(6):753-61.

  • Ivics Z., …, Izsvák Z, Transposon-mediated genome manipulations in vertebrates. Nature Methods 2009; 6(6):415-22.

  • Sinzelle L., …, Izsvák Z, and Ivics Z, Transposition of a Reconstructed Harbinger Element in Human Cells and Functional Homology with Two Human Cellular Genes Proc. Natl. Acad. Sci. USA, 2008; 105(12):4715-2

  • Ivics Z, ..., Izsvák Z, Targeted Sleeping Beauty Transposition in Human Cells. 2007; Mol. Therapy 15(6):1137-44

  • zsvák Z, et al., (2004) Healing the wounds inflicted by Sleeping Beauty transposition by double-strand break repair in mammalian somatic cells. Mol. Cell 13:279-290.

  • Yant SR, … Izsvák Z, Kay MA, Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system. 2000; Nature Genet. 25:35-41


Membership in scientific bodies/juries

  • Advisor of the Danish Council for Strategic Research

  • American Society of Gene and Cell Therapy

  • European Science Foundation – reviewer

  • European Society of Gene and Cell Therapy

  • First Secretary of the EURYIAS Academy (Candidate)

  • Guest editor of a special issue in Seminars in Cancer Biology, “Repetitive elements and genome instability” – containing 8 articles

  • Guest editor of a special issue of semi entitled “Transposons in vertebrate functional genomics” containing 16 review articles written by leaders of the field, and accessible at http://genomebiology.com/supplements/8/S1.

  • Inventor of 9 granted and pending patents in transposon technology

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News

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    Stem cells are essential for the repair of muscle damage, but all attempts to manipulate muscle stem cells for therapy have failed until now. Prof. Simone Spuler and Dr. Andreas Marg of the Experimental and Clinical Research Center ECRC in Berlin now developed a method to cultivate and transplant these cells along with their muscle fibers.