Short CV/Education and training

  • 1990 – 1991
    researcher, 1 fte, tenured term, Swiss Institute for Allergy and Asthma research, Davos, Switzerland

  • 1991 – 1997
    PhD project, 1 fte, fixed term, Department of Dermatology, University Medical Center Utrecht, The Netherlands. Supervision 1 technician.

  • 1993 – 1994
    Visiting Scientist, Department of Hematology, University Hospital Zurich, Zurich, Switzerland.

  • 1997 – 2004
    Post-doc, 1 fte, fixed term, Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Supervision 2-4 technicians, 2-3 AGIKOs/PhD students, 2-3 post-docs.

    2004 – 2009
    Staff member Department of Tumor Immunology, 0.5 fte tenured; Department of Pediatric Hemato-oncology 0.5 fte fixed term, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Supervision 6 technicians, 4 AGIKOs/PhD students, 4 post-docs.

  • 2009 – 2011
    Senior lecturer, Department of Tumor Immunology 0.75 fte and Medical Oncology 0.25 fte, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Supervision 8 technicians, 4 AGIKOs/PhD students, 4 post-docs.

  • since 2011
    Professor Translational Tumor Immunology, Department of Tumor Immunology 0.75 fte and Medical Oncology 0.25 fte, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. Supervision 7 technicians, 3 AGIKOs/PhD students, 3 post-docs.

Selected publications

  • Tel J, Schreibelt G, Sittig SP, Mathan TS, Buschow SI, Cruz LJ, Lambeck AJ, Figdor CG, de Vries IJ. Human plasmacytoid dendritic cells efficiently cross-present exogenous Ags to CD8+ T cells despite lower Ag uptake than myeloid dendritic cell subsets. Blood, 2013. 121(3): 459-67.

  • Jacobs JF, Nierkens S, Figdor CG, de Vries IJ, Adema GJ. Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy? The lancet oncology, 2012. 13(1): e32-42.

  • Schreibelt G, Klinkenberg LJ, Cruz LJ, Tacken PJ, Tel J, Kreutz M, Adema GJ, Brown GD, Figdor CG, de Vries IJ. The C-type lectin receptor CLEC9A mediates antigen uptake and (cross-)presentation by human blood BDCA3+ myeloid dendritic cells. Blood, 2012. 119(10): 2284-92.

  • Tel J, Smits EL, Anguille S, Joshi RN, Figdor CG, de Vries IJ. Human plasmacytoid dendritic cells are equipped with antigen-presenting and tumoricidal capacities. Blood, 2012. 120(19): 3936-44.

  • Lesterhuis WJ, Punt CJ, Hato SV, Eleveld-Trancikova D, Jansen BJ, Nierkens S, Schreibelt G, de Boer A, Van Herpen CM, Kaanders JH, van Krieken JH, Adema GJ, Figdor CG, de Vries IJ. Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice. The Journal of clinical investigation, 2011. 121(8): 3100-8.

  • Schreibelt G, Benitez-Ribas D, Schuurhuis D, Lambeck AJ, van Hout-Kuijer M, Schaft N, Punt CJ, Figdor CG, Adema GJ, de Vries IJ. Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells. Blood, 2010. 116(4): 564-74.

  • Srinivas M, Aarntzen EH, Bulte JW, Oyen WJ, Heerschap A, de Vries IJ, Figdor CG. Imaging of cellular therapies. Adv Drug Deliv Rev, 2010. 62(11): 1080-93.

  • Meyer-Wentrup F, Benitez-Ribas D, Tacken PJ, Punt CJ, Figdor CG, de Vries IJ, Adema GJ. Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production. Blood, 2008. 111(8): 4245-53.

  • Benitez-Ribas D, Adema GJ, Winkels G, Klasen IS, Punt CJ, Figdor CG, de Vries IJ. Plasmacytoid dendritic cells of melanoma patients present exogenous proteins to CD4+ T cells after Fc gamma RII-mediated uptake. J Exp Med, 2006. 203(7): 1629-35.

  • Tacken PJ, de Vries IJ, Gijzen K, Joosten B, Wu D, Rother RP, Faas SJ, Punt CJ, Torensma R, Adema GJ, Figdor CG. Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody. Blood, 2005. 106(4): 1278-85.


Selected projects

  • Swedish Research Society 2013: Dissecting mechanisms exploited by plasmacytoid dendritic cells for antitumor immunity in therapeutically vaccinated prostate cancer patients. Supervisors: IJM de Vries, R. Kiessling

  • RIO JO project 2013: Dissecting mechanisms exploited by plasmacytoid dendritic cells for antitumor immunity in prostate cancer patients. Principal Investigator: IJM de Vries, W. Gerritsen

  • NWO-ZonMW 2012:pTO 95103002: Natural circulating plasmacytoid dendritic cells: Key for antitumor immunity? Principal Investigator: IJM de Vries

  • BetaTrain: European Training Network for Excellence in Molecular Imaging in Diabetes, EC FP7 ITN.

  • KWF 2010-4722: Vaccination of early-stage high-risk uveal melanoma patients with mRNA-transfected dendritic cells. Principal investigators: IJM de Vries, CJA Punt, ADA Paridaens.

  • KWF 2006-3699: Toll like receptor-mediated dendritic cell maturation: The key towards induction of potent anti-tumor immunity? Principal investigators: IJM de Vries, GJ Adema, CJA Punt.

  • NWO Vidi: Dendritic Cells en route. Principal investigator: IJM de Vries.

  • NWO Aspasia. Principal investigator: IJM de Vries.

  • ENCITE, European Network for Cell Imaging and Tracking Expertise, EC FP7 project.

  • Pharmachild, Long-term PHARMacovigilance for adverse effects in childhood arthritis focusing on immune modulatory drugs, EC FP7 project.

  • NWO-ZonMW 2008: pTO 95100106: Boosting the immune response to prevent cancer: Frameshift neopeptide-derived antigens as novel tumor specific targets for immune therapy in hereditary colorectal cancer. Principal investigators: IJM de Vries, N. Hoogerbrugge.

  • KWF 2009-4580: NPK project translational research.

  • Van der Es foundation 222, 2010: STAT6 en platinum-chemotherapie gevoeligheid. Principal investigators: WJ Lesterhuis, CJA Punt, IJM de Vries.

Patents

  • Composition and methods for generating an immune response in a subject

  • Peptides for use in the immunotherapy of renal cell carcinoma

Membership in scientific bodies/juries

  • Organizer of ENCITE workshops ‘ Imagine Cancer: from Models to Patients’, Nijmegen (the Netherlands) 1/2012

  • Member of the training and supervision plan committee of the clinical institutes of RUN-MC.

  • Member of the management team NCMLS since 01/2011

  • Organizer of the 2010 edition of the Dutch Tumor Immunology Meeting (Breukelen, The Netherlands, 06/2011)

  • Organizer of the 2010 edition of the Dutch Tumor Immunology Meeting (Breukelen, The Netherlands, 06/2010)

  • Site visit of the research cancer center headed by Jean Jacques Fournié in Toulouse (France). On behalf of the French National Agency for Research Evaluation (AERES), November 19-20, 2009

  • Application for CCMO permission to perform clinical trials

  • Organizer of the 2009 edition of the Dutch Tumor Immunology Meeting (Breukelen, The Netherlands, 06/2009)

  • Co-organizer of N4I science day 2009, 2010,2011

  • Member of the NCMLS seminar committee, 11/2009 – 5/2011

  • Organizer of the 2008 edition of the Dutch Tumor Immunology Meeting (Breukelen, The Netherlands, 06/2008)

  • Co-organizer of the conference DC2003 (Amsterdam, The Netherlands)

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