Short CV/Education and training

  • 1987 – 1993
    PhD student, New York University, Departments of Chemistry and Biology

  • 1993 – 1995
    Post-doctoral fellow at Albert Einstein College of Medicine, New York

  • 1995 – 1997
    Post-doctoral fellow at Harvard Medical School, Boston

  • 1997 – 1999
    Staff scientist in X-ray crystallography, Wyeth Research, Cambridge, MA, USA

  • 1999 – 2000
    Visiting scientist at the EMBL Grenoble; consultant for Wyeth Research, Cambridge, USA

  • 2001 – 2005
    CNRS Researcher (CR1); Laboratoire de Cristallographie Macromoléculaire, IBS, Grenoble

  • 2005 – 2012
    CNRS Research director (DR2), Bacterial Pathogenesis Group, IBS

  • Since 2012
    Professor at the Universidade Estadual de Campinas (Unicamp; Professor Pleno)

  • Since 2012
    Director of an 'International Associated Laboratory (CNRS)' between France and Brazil

  • 2013
    CNRS Research director (DR1), Bacterial Pathogenesis Group, Institut de Biologie Structurale

Selected publications

  • Neves D, and Dessen, A (2012) Sensing stability. Nature Chem. Biol. 8, 681-682.

  • Gendrin C et al. (2012) Structural basis of cytotoxicity mediated by the type III secretion toxin ExoU from Pseudomonas aeruginosa. PLoS Pathog. e1002637.

  • Lebreton A et al. (2011) A bacterial protein targets the BAHD1 chromatin silencing complex to stimulate interferon-g response. Science 331, 1319-1320.

  • Izoré, T. et al. (2010) Structural basis of host cell recognition by the pilus adhesin from Streptococcus pneumoniae. Structure 18, 106-115.

  • Macheboeuf, P. et al. (2007) Structural and mechanistic basis of penicillin-binding protein inhibition by lactivicins. Nature Chem. Biol. 3, 565-569.

  • Quinaud, M. et al. (2007) Structure of the heterotrimeric complex that regulates type III secretion needle formation. Proc. Natl. Acad. Sci. USA 104, 7803-7808.

  • Macheboeuf, P. et al. (2005). Active site restructuring regulates ligand recognition in class A penicillin-binding proteins (PBPs). Proc. Natl. Acad. Sci. USA 102, 577-582.

  • Schoehn, G. et al. (2003). Oligomerization of type III secretion proteins PopB and PopD precedes pore formation in Pseudomonas. EMBO J. 22, 4957-4967.

  • Dessen, A. et al. (1999) Crystal structure of human cytosolic phospholipase A2 reveals a novel topology and catalytic mechanism. Cell 97, 349-360.

  • Weissenhorn, W., Dessen, A. et al. (1997) Atomic structure of the ectodomain from HIV-1 gp41. Nature 387, 426-430.

  • Dessen, A. et al. (1995) Crystal structure and function of wild type and drug-resistant forms of the isoniazid target of Mycobacterium tuberculosis. Science 267, 1638-1641.



Complete list of publications

Selected projects

  • mechanisms of antibiotic resistance of bacterial pathogens

  • structure and function of bacterial toxin secretion complexes

  • mechanism of cell wall formation in bacteria

  • bacterial virulence factors and interactions with the eukaryotic host

Membership in scientific bodies/juries

  • Member of Faculty of 1000

  • Member of the Executive Committee, FINOVI Foundation, France

  • Member of the Scientific, Medical and Technological Steering Committee, IRT BIOASTER, France

  • Member of the Microbiology and Infection Committee of the National Research Agency (ANR), France

  • Referee for: EMBO Long/short term fellowships/

    ERC Young Investigator Program/Swedish Foundation for Strategic Research/Belgian National Research Fund (FNRS)/Netherlands Organization for Scientific Research (NWO)/ANR

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