Short CV/Education and training

Education:

  • 1997
    M.Sc., Faculty of Biology, Warsaw University, Poland

  • 2001
    Ph.D., Physiology/Biochemistry, Medical University of Bialystok, Poland

  • 2006
    D.Sc., Physiology/Biochemistry, Medical University of Bialystok, Poland

Training and Positions:

  • 1992 – 1997
    MSc degree programme in Biology, Warsaw University, Poland

  • 1997
    Fellow, Department of Biochemistry, University of Munster, Munster, Germany

  • 2001
    Fellow, Department of Surgery, Vienna University Hospital, Vienna, Austria

  • 1997 – 2001
    Research Scientist, Department of Physiology, Medical University of Bialystok, Poland

  • 2002 – 2006
    Postdoctoral Fellow/Senior Postdoctoral Fellow, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA

  • Since 2007
    Head of the Laboratory of Cell Signaling and Metabolic Disorders, Nencki Institute of Experimental Biology, Warsaw, Poland

Selected publications

  • Dobrzyn P, Bednarski T, Dobrzyn A: Metabolic reprogramming of the heart through stearoyl-CoA desaturase. Prog Lipid Res 2015, 57C:1-12.

  • Malodobra-Mazur M, Dziewulska A, Kozinski K, Dobrzyn P, Kolczynska K, Janikiewicz J, Dobrzyn A: Stearoyl-CoA desaturase regulates inflammatory gene expression by changing DNA methylation level in 3T3 adipocytes. Int J Biochem Cell Biol 2014, 55: 40-50.

  • Malenczyk K, Jazurek M, Keimpema E, Silvestri C, Janikiewicz J, Mackie K, Di Marzo V, Redowicz MJ, Harkany T, Dobrzyn A: CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release. J Biol Chem 2013, 288: 32685-32699.

  • Banach M, Malodobra-Mazur M, Gluba A, Katsiki N, Rysz J, Dobrzyn A: Statin therapy and new-onset diabetes: molecular mechanisms and clinical relevance. Curr Pharm Des 2013, 19: 4904-4912.

  • Dobrzyn P, Jazurek M, Dobrzyn A: Stearoyl-CoA desaturase and insulin resistance – What is the molecular switch. Biochim Biophys Acta – Bioenerg 2010, 1797: 1189-1194.

  • Miyazaki M, Dobrzyn A, Elias PM, Ntambi JM: Stearoyl-CoA desaturase-2 gene expression is required for lipid synthesis during early skin and liver development. Proc Natl Acad Sci USA 2005, 102: 12501-12506.

  • Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM: Stearoyl-CoA desaturase 1 deficiency reduces ceramide synthesis by down-regulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle. Am J Physiol Endocrinol Metab 2005, 288: E599-E607.

  • Dobrzyn P, Dobrzyn A, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM: Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc Natl Acad Sci USA 2004, 101: 6409-6414.



Complete list of publications

Selected projects

  • Foundation for Polish Science, grant TEAM (TEAM/2010-5/2) entitled: Molecular mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. (2010 – 2015)

  • European Molecular Biology Organization (EMBO), grant 1643, Project title: Molecular mechanism of lipid-induced insulin resistance. (2008 – 2013)

  • BIO-IMAGINE grant within EU FP7 programme, Project title: Bio-imaging in research innovation and education. WP1: Increasing human potential. (2011 – 2014)

  • American Heart Association (AHA), grant 0420051Z, Project title: The role of stearoyl-CoA desaturase expression in steatosis and lipoapoptosis. (2004 – 2005)

Membership in scientific bodies/juries

  • Panel member in a number of granting agencies, including Polish National Science Center, Foundation for Polish Science, Ministry of Science and Higher Education, European Research Council

Media coverage

  • After success abroad, a Polish scientist returns home, Science Careers:

  • No place like home. Nature 461/1, 2009, 682-683.

  • Scientific Careers in Poland, LabTimes, 2011, 2: 75-82.

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