Short CV/Education and training

  • 2002 – 2003
    Undergraduate Research Assistant; Gulbenkian Institute for Science, Oeiras, Portugal

  • 2003 – 2008
    Graduate student; University of Lausanne, Lausanne, Switzerland

  • 2008 – 2009
    SNF (Swiss National Science Foundation) Postdoctoral Fellow; University of Oxford, Oxford, England

  • 2009 – 2010
    FCT (Portuguese Science Foundation) Postdoctoral Fellow; University of Oxford, Oxford, England

  • 2011 – 2012
    Marie Curie IECD Fellow; University of Oxford, Oxford, England

  • 2013
    Research Fellow; University of Oxford, Oxford, England

  • 2013 – 2014
    Dorothy Hodgkin's Research Fellow, Royal Society; University of Oxford, Oxford, England

  • Since 2014
    SNF Assistant Professor; University of Lausanne, Switzerland

Selected publications

  • Ponting, and A C Marques, "Extensive miRNA mediated crosstalk between lncRNAs and mRNA in mouse Embryonic Stem Cells", Genome Research 25, 655-666 (2015)

    50% of lncRNAs studied induce changes in their targets in a miRNA-depedent manner.

  • J Y Tan, K W Vance, M A Varela, T Sirey, L M Watson, H J Curtis, M Marinello, S Alves, B R Steinkraus, S Cooper, T Nesterova, N Brockdorff, T A Fulga, A Brice, A Sittler, P L Oliver, M J Wood, C P Ponting and A C Marques "Cross-talking noncoding RNAs contribute to cell-specific neurodegeneration in SCA7", Nature Structural & Molecular Biology 21, 955–961 (2014). Regulatory crosstalk involving a miRNA, a lincRNA and the ATXN7-the SCA7 disease causing gene-explains tissue specific neurodegeneration in SCA7 patients.

  • A. C. Marques, J. Hughes, B. Graham, M. S. Kowalczyk, D. R HiggsTan and C. P. Ponting, "Chromatin signatures at transcriptional start sites separate two equally populated et distinct classes of intergenic long noncoding RNAs", Genome Biology (2013) 14 R131. Fifty percent of intergenic lncRNAs are transcribed from enhancers and the transcription of these enhancer associated molecules is correlated with enhanced levels of genes in their vicinity.

  • C. Kutter, S. Watt, K. Stefflova, M. D. Wilson, A. Goncalves, C. P. Ponting, D.T. Odom, A. C. Marques. "Rapid Turnover of Long Noncoding RNAs and the Evolution of Gene Expression", PLoS Genetics (2012), 8(7): e1002841. LincRNA transcription was frequently gained and lost during evolution and associates with neighboring gene expression levels.

  • A. C. Marques and Chris P. Ponting "Catalogues of mammalian long noncoding RNAs: modest conservation and incompleteness". Genome Biology (2009); 10(11):R124. LincRNA are conserved, albeit at lower levels than protein-coding genes. Detection of their sequence conservation requires appropriate tests.

Selected projects

  • Contributions of intergenic lncRNAs to homeostasis and Disease


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