Short CV/Education and training

  • 1983
    Abitur (A-levels), Steglitz Gymnasium (grammar school) for the humanities, Berlin, Germany

  • 1984 – 1988
    Studied Chemistry at TU Berlin

  • 1988
    Diplom thesis at the Max Planck Institute for Molecular Genetics, Berlin

  • 1989 – 1992
    Doctoral thesis at the Institute for Genetic Biological Research, Berlin

  • 1992 – 1993
    Postdoc in developmental biology at Stanford University, USA

  • 1999
    Habilitation (postdoctoral qualification), Ulm University, Germany

Selected publications

  • Hölzle, A. et al.: Maturation of the 5S rRNA 5' end is catalysed in vitro by the endonuclease tRNase Z in the archaeon Haloferax volcanii. In: RNA 14, 2008. pp. 928-937.

  • Späth, B. et al.: Analysis of the functional modules of the tRNA 3' endonuclease (tRNase Z). In: J Biol Chem 280, 2005. pp. 35440-35447.

  • Dubrovsky, E. B. et al.: Drosophila RNase Z processes mitochondrial and nuclear pre-tRNA 3' ends in vivo. In: Nucleic Acids Res 32, 2004. pp. 255-262.

  • Pellegrini, O. et al.: Endonucleolytic processing of CCA-less tRNA precursors by RNase Z in Bacillus subtilis. In: EMBO J 22, 2003. pp. 4534-4543.

  • Kruszka, K. et al.: Plant dicistronic tRNA-snoRNA genes: a new mode of expression of the small nucleolar RNAs processed by RNase Z. In: EMBO J 22, 2003. pp. 621-632.

  • Schiffer, S., Rösch, S., Marchfelder, A.: Assigning a function to a conserved group of proteins: The tRNA 3' processing enzymes. In: EMBO J 21, 2002. pp. 2769-2777.

  • Kunzmann, A., Brennicke, A., Marchfelder, A.: 5' end maturation and RNA editing have to precede tRNA 3' processing in plant mitochondria. In: Proc Natl Acad Sci, USA 95, 1998. pp. 108-113.


Selected projects

  • RNA metabolism in archaea

Membership in scientific bodies/juries

  • Advisory board of the Society of Biochemistry and Molecular Biology (GMB) study group RNA Biochemistry

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