Short CV/Education and training

Present appointment

  • Vice-President and Head, Experimental Medicine Unit, ImmunoInflammation Therapy Area Unit, R&D GlaxoSmithKline, Stevenage, UK

Current 'external facing' activities include

  • Honorary Professor of Nephrology, University of Birmingham

  • Honorary Senior Fellow, University of Cambridge

Previous appointments

  • 1983 – 1987
    MRC Clinical Training Fellow, Royal Postgraduate Medical School, London

  • 1987 – 1989
    Senior Registrar in Nephrology and General Medicine. Hammersmith Hospital, London

  • 1989 – 1990
    MRC Travelling Fellow, Brigham & Women's Hospital and Harvard Medical School, Boston, USA

  • 1990 – 1993
    MRC Clinical Scientist, Clinical Research Centre, Harrow, and Honorary Consultant Nephrologist, Renal Unit, Hammersmith Hospital, London

  • 1993 – 1998
    Senior Lecturer in Nephrology, The Medical School, University of Birmingham

  • 1998 – 2010
    Professor of Nephrology and Deputy Head of the Division of Immunity and Infection, Institute of Biomedical Research, The Medical School, University of Birmingham, Edgbaston, Birmingham

  • 2000 – 2010
    Director of The Wellcome Trust Clinical Research Facility in Birmingham

Previous other activities

  • 2007 – 2010
    Academic Vice President, Renal Association, and de facto Member of the Executive Committee and Trustees

  • 2008 – 2010
    Chair, Renal Speciality Group, National Institute Health Research, Late Trustee, Kidney Research UK and Chair of Strategy Committee

  • 2009 – 2012
    Council, Academy of Medical Sciences

  • 2012 – 2015
    Academy of Medical Sciences Fellowship and Sectional Committees

Selected publications

  • I moved to Industry in 2010, so the publications reflect previous academic work:

  • Williams JM, Savage COS. Characterisation of the regulation and functional consequences of p21ras activation in neutrophils by antineutrophil cytoplasm antibodies. J Am Soc Nephrol, 2005, 16:90-96

  • Lu X, Garfield A, Savage COS, Nash GB. Mediation of endothelial cell damage by serine proteases, but not superoxide, released from antineutrophil cytoplasmic antibody-stimulated neutrophils. Arthritis Rheum, 2006, 54:1619-1628

  • Williams JM, Pettitt TR, Powell W, Grove J, Savage COS, Wakelam MJO. Anti-neutrophil cytoplasm antibody-stimulated neutrophil adhesion is dependent upon diacylglycerol kinase-catalyzed phosphatidic acid formation. J Am Soc Nephrol, 2007, 18:1112-1120

  • Ferraro A, Drayson M, Savage COS, MacLennan I. While autoantibody titers fall after B cell depletion by Rituximab, levels of natural antibody and antibody against all classes of extrinsic antigen persist. Eur J Immunol, 2008, 38:292-298

  • Nolan S, Kalia N, Nash G, Kamel D, Heeringa P, Savage COS. Murine antineutrophil cytoplasmic antibodies increase leukocyte-endothelial cell interactions in vivo with a critical role for Fc receptors. J Am Soc Nephrol, 2008, 19:973-984

  • De Groot K, Harper L, Jayne DRW, Suarez LFF, Gregorini G, Gross WL, Luqmani R, Pusey CD, Rasmussen N, Sinico RA, Tesar V, Vanhille P, Westman K, Savage COS, for the European Vasculitis Study Group (EUVAS). Pulse versus daily oral cyclophosphamide for induction of remission in ANCA-associated vasculitis. Ann Int Med 2009, 150: 670-680

  • Jones RB, Cohen Tevaert JW, Hauser T, Luqmani R, Morgan M, Peh CA, Savage COS, Segelmark M, Tesar V, Van Passen P, Walsh D, Walsh M, Westman K, Jayne DRW. Randomised trial of rituximab versus cyclophosphamide in ANCA associated renal vasculitis 'RITUXVAS'. New Engl J Med, 2010, 363:211-20

  • Smith SW, Eardley KS, Croft A, Nwosu J, Howie AJ, Cockwell P, CIsacke CM, Buckley CD, Savage COS. CD248+ stromal cells and determinants of progressive chronic kidney disease. Kidney Int 2011, 80:199-207

  • Holden NJ, Williams JM, Morgan MD, Challa A, Gordon J, Pepper RJ, Salama AD, Harper L, Savage CO. ANCA-stimulated neutrophils release BLyS and promote B cell survival: a clinically relevant cellular process. Ann Rheum Dis. 2011 Dec;70(12):2229-33

  • Tull SP, Bevins A, Kuravi SJ, Satchell SC, Al-Ani B, Young SP, Harper L, Williams JM, Rainger GE, Savage CO. PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells. PLoS One. 2012;7(8):e43916. doi: 10.1371/journal.pone.0043916. Epub 2012 Aug 29.


Selected projects

  • Academy of Medical Sciences Working party for 'Reproducibilty and reliability of biomedical research'. Report published 2015

  • Academy of Medical Sciences Working party for 'Team Science'. 2015 (ongoing)

  • Scientific lead for EMINENT: a collaboration between MRC, GlaxoSmithKLine and five Universities for development of experimental medicine studies in areas of unmet need.

Membership in scientific bodies/juries

  • Royal College of Physicians of London

  • Academy of Medical Sciences

  • PSMB Board, Medical Research Council

Additional qualifications

  • F.R.C.P., London, 1996

  • F.Med.Sci, London, 2004


Soft Skills/Other activities and achievements

Soft Skills

  • I am interested in womens leadership, I was nominated by GSK to attend an INSEAD Women's Leadership course in 2014.


Other activities and achievements/family

  • I have two daughters who have qualified in medicine and veterinary medicine. I run, sail and ski. I play the piano (not very well) to relax.


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News

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