Short CV/Education and training

  • 1986 – 1992
    Study of Biology at the Justus Liebig University Giessen, Germany (BSc/MSc)

  • 1989
    Study year abroad at the University of Sussex, Falmer, UK

  • 1992 – 1993
    Research Assistant, Imperial Cancer Research Fund, London UK

  • 1994 – 1997
    Doctoral study at the Imperial Cancer Research Fund, London, UK (laboratory of Dr Fiona Watt; PhD awarded in 1997 by Imperial College London)

  • 1997 – 1999
    Postdoctoral Research Fellow at the National Institute for Medical Research, London, UK (laboratory of Dr Robb Krumlauf)

  • 2000 – 2003
    Postdoctoral Research Fellow at the Imperial Cancer Research Fund, London, UK (laboratory of Dr David Shima)

  • 2003 – 2007
    Principal Research Fellow at the UCL Institute of Ophthalmology, University College London, UK

  • 2007 – 2008
    Lecturer (Assistant Professor) at the UCL Institute of Ophthalmology, University College London, UK

  • 2008 – 2009
    Reader (Associate Professor) at the UCL Institute of Ophthalmology, University College London, UK

  • since 2010
    Assistant Professor Adjunct, Yale University Medical School

  • since 2011
    Professor of Neuronal and Vascular Biology at the UCL Institute of Ophthalmology, University College London, UK

Selected publications

  • Lanahan, A., Zhang, X., Fantin, A., Zhuang, Z.W., Rivera-Molina, F., Speichinger, K.R., Prahst, C., Zhang, J., Wang, Y., Davis, G.E., Toomre, D., Ruhrberg, C*. and Simons M. (2013). The Neuropilin-1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Developmental Cell 25(2): 156-68.

  • Fantin, A., Vieira, J. M., Plein, A. R., Maden, C. H. and Ruhrberg, C. (2013). The embryonic mouse hindbrain as a qualitative and quantitative model to study the molecular and cellular mechanisms of angiogenesis. Nature Protocols 8(2): 418-29.

  • Fantin, A., Schwarz, Q., Davidson, K., Normando, E.M., Denti, L. and Ruhrberg, C. (2011). The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins. Development 138 (19):4185-91. Faculty of 1000: recommended read; http://f1000.com/12918956

  • Cariboni, A., Davidson, K., Dozio, E., Stossi, F., Parnavelas, J. G., Ruhrberg, C. (2011). VEGF isoform signalling controls GnRH neuron survival via NRP1, independently of VEGFR2/KDR and blood vessels. Development 138(17):3723-3733.

  • Erskine, L., Reijntjes, S., Pratt. T., Denti, L., Schwarz. Q., Vieira, J. M. V., Alakakone, B., Shewan, D., Ruhrberg, C. (2011). VEGF signalling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron 70(5):951-965. Editorial: VEGF shows its attractive side at the midline. Neuron 70(5):808-812. Wellcome Trust news: http://www.wellcome.ac.uk/News/2011/News/WTVM051715.htm. Faculty of 1000: must read; http://f1000.com/11300957

  • Cariboni, A., Davidson, K., Maggi, R., Rakic, S., Parnavelas, J. G, Ruhrberg, C. (2011). Defective GnRH neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for Kallmann Syndrome. Human Molecular Genetics 20:336-344. Lay articles, e.g. http://www.bbsrc.ac.uk/news/health/2010/101129-pr-sex-hormones-rerouted.aspx and http://www.ucl.ac.uk/news/news-articles/1011/10112904

  • Fantin, A., Vieira, J. M., Gestri, G., Denti, L., Schwarz, Q., Prykhozhij, S., Peri, F., Wilson S. W., Ruhrberg, C. (2010). Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood 116 (5): 829-840. Nature New & Views: Bridges that guide and unite (2010). Nature 465: 697-699. Faculty of 1000 Biology evaluation: must read; http://www.f1000biology.com/article/id/116078

  • Schwarz, Q., Maden C., Vieira, J.M.V., Ruhrberg, C. (2009). Neuropilin 1 signalling guides neural crest cells to coordinate pathway choice with cell specification. Proc Natl Acad Sci USA 106:6164-69. Faculty of 1000 Biology evaluation: recommended; http://f1000.com/1159368

  • Schwarz, Q., Gu, C., Fujisawa, H., Sabelko. K., Gertsenstein, M., Nagy, A., Taniguchi, M., Kolodkin, A. L., Ginty, D. D., Shima, D. T. and Ruhrberg, C. (2004). Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve. Genes Dev 18:2822-34.

  • Ruhrberg, C., Gerhardt, H., Golding, M., Watson, R., Ioannidou, S., Fujisawa, H., Betsholtz, C. and Shima, D.T. (2002). Spatially-restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching. Genes & Development 16: 2684-2698. Faculty of 1000 Biology: recommended; http://f1000.com/1010354. Editorial: Branching out requires VEGF (2002). Journal of Cell Biology 159:201.



Complete list of publications

Selected projects

  • VEGF signalling in the nervous system

  • Neuropilin regulation of angiogenesis, arteriogenesis and vascular permeability

  • VEGF and semaphorin signalling in neuropilin-mediated neural crest cell patterning

Membership in scientific bodies/juries

  • The Wellcome Trust Peer Review College, since 2013

  • Editor, PLoS One, since 2008

  • Member, North American Vascular Biology Organisation, since 2003

  • Member, British Society for Developmental Biology, since 1998

  • Member, UK Biochemical Society, since 1995

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News

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    Christiana Ruhrberg studies how nerves and blood vessels grow and branch. Her research has shown how the body uses the same set of molecular signals to instigate blood vessel growth and nerve growth in the eye and brain.