Short CV/Education and training

  • 1986 – 1992
    Study of Biology at the Justus Liebig University Giessen, Germany (BSc/MSc)

  • 1989
    Study year abroad at the University of Sussex, Falmer, UK

  • 1992 – 1993
    Research Assistant, Imperial Cancer Research Fund, London UK

  • 1994 – 1997
    Doctoral study at the Imperial Cancer Research Fund, London, UK (laboratory of Dr Fiona Watt; PhD awarded in 1997 by Imperial College London)

  • 1997 – 1999
    Postdoctoral Research Fellow at the National Institute for Medical Research, London, UK (laboratory of Dr Robb Krumlauf)

  • 2000 – 2003
    Postdoctoral Research Fellow at the Imperial Cancer Research Fund, London, UK (laboratory of Dr David Shima)

  • 2003 – 2007
    Principal Research Fellow at the UCL Institute of Ophthalmology, University College London, UK

  • 2007 – 2008
    Lecturer (Assistant Professor) at the UCL Institute of Ophthalmology, University College London, UK

  • 2008 – 2009
    Reader (Associate Professor) at the UCL Institute of Ophthalmology, University College London, UK

  • since 2010
    Assistant Professor Adjunct, Yale University Medical School

  • since 2011
    Professor of Neuronal and Vascular Biology at the UCL Institute of Ophthalmology, University College London, UK

Selected publications

  • Lanahan, A., Zhang, X., Fantin, A., Zhuang, Z.W., Rivera-Molina, F., Speichinger, K.R., Prahst, C., Zhang, J., Wang, Y., Davis, G.E., Toomre, D., Ruhrberg, C*. and Simons M. (2013). The Neuropilin-1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Developmental Cell 25(2): 156-68.

  • Fantin, A., Vieira, J. M., Plein, A. R., Maden, C. H. and Ruhrberg, C. (2013). The embryonic mouse hindbrain as a qualitative and quantitative model to study the molecular and cellular mechanisms of angiogenesis. Nature Protocols 8(2): 418-29.

  • Fantin, A., Schwarz, Q., Davidson, K., Normando, E.M., Denti, L. and Ruhrberg, C. (2011). The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins. Development 138 (19):4185-91. Faculty of 1000: recommended read;

  • Cariboni, A., Davidson, K., Dozio, E., Stossi, F., Parnavelas, J. G., Ruhrberg, C. (2011). VEGF isoform signalling controls GnRH neuron survival via NRP1, independently of VEGFR2/KDR and blood vessels. Development 138(17):3723-3733.

  • Erskine, L., Reijntjes, S., Pratt. T., Denti, L., Schwarz. Q., Vieira, J. M. V., Alakakone, B., Shewan, D., Ruhrberg, C. (2011). VEGF signalling through neuropilin 1 guides commissural axon crossing at the optic chiasm. Neuron 70(5):951-965. Editorial: VEGF shows its attractive side at the midline. Neuron 70(5):808-812. Wellcome Trust news: Faculty of 1000: must read;

  • Cariboni, A., Davidson, K., Maggi, R., Rakic, S., Parnavelas, J. G, Ruhrberg, C. (2011). Defective GnRH neuron migration in mice lacking SEMA3A signalling through NRP1 and NRP2: implications for Kallmann Syndrome. Human Molecular Genetics 20:336-344. Lay articles, e.g. and

  • Fantin, A., Vieira, J. M., Gestri, G., Denti, L., Schwarz, Q., Prykhozhij, S., Peri, F., Wilson S. W., Ruhrberg, C. (2010). Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction. Blood 116 (5): 829-840. Nature New & Views: Bridges that guide and unite (2010). Nature 465: 697-699. Faculty of 1000 Biology evaluation: must read;

  • Schwarz, Q., Maden C., Vieira, J.M.V., Ruhrberg, C. (2009). Neuropilin 1 signalling guides neural crest cells to coordinate pathway choice with cell specification. Proc Natl Acad Sci USA 106:6164-69. Faculty of 1000 Biology evaluation: recommended;

  • Schwarz, Q., Gu, C., Fujisawa, H., Sabelko. K., Gertsenstein, M., Nagy, A., Taniguchi, M., Kolodkin, A. L., Ginty, D. D., Shima, D. T. and Ruhrberg, C. (2004). Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve. Genes Dev 18:2822-34.

  • Ruhrberg, C., Gerhardt, H., Golding, M., Watson, R., Ioannidou, S., Fujisawa, H., Betsholtz, C. and Shima, D.T. (2002). Spatially-restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching. Genes & Development 16: 2684-2698. Faculty of 1000 Biology: recommended; Editorial: Branching out requires VEGF (2002). Journal of Cell Biology 159:201.

Complete list of publications

Selected projects

  • VEGF signalling in the nervous system

  • Neuropilin regulation of angiogenesis, arteriogenesis and vascular permeability

  • VEGF and semaphorin signalling in neuropilin-mediated neural crest cell patterning

Membership in scientific bodies/juries

  • The Wellcome Trust Peer Review College, since 2013

  • Editor, PLoS One, since 2008

  • Member, North American Vascular Biology Organisation, since 2003

  • Member, British Society for Developmental Biology, since 1998

  • Member, UK Biochemical Society, since 1995


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