Short CV/Education and training

  • 1995 – 2000
    M.Sc. degree in biochemistry, University of Valencia, Spain

  • 2000 – 2003
    M.Sc. degree in chemistry, University of Valencia, Spain

  • 2000 – 2005
    Doctorate in the group Dr Jesus Salgado, University of Valencia

  • 2005 – 2009
    Postdoc, Dresden University of Technology

  • 2010 – 2013
    Independent research group leader, Max Planck Institute for Metals Research and German Cancer Research Centre (DKFZ), Germany

  • Since 2013
    Full Professor at University of Tübingen, Germany

Selected publications

  • Bleicken S, Landeta O, Landajuela A, Basañez G, García-Sáez AJ. Proapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable size. J Biol Chem. 2013;288(46):33241-52.

  • Bleicken S, Wagner C, García-Sáez AJ. Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis. Biophys J. 2013;104(2):421-31.

  • Apellániz B, Nieva JL, Schwille P, García-Sáez AJ. All-or-none versus graded: single-vesicle analysis reveals lipid composition effects on membrane permeabilization. Biophys J. 2010; 99(11):3619-28.

  • García-Sáez, A.J. et al.: Membrane promotes tBid interaction with Bcl-xL. In: Nature Structural and Molecular Biology 16(11), 2009. pp. 1178-1185.

  • García-Sáez, A.J., Chiantia, S., Schwille, P.: Effect of line tension on the lateral organization of lipid membranes. In: Journal of Biological Chemistry 282(46), 2007. pp. 33537-33544.

  • García-Sáez, A.J. et al.: Membrane insertion fragments of Bcl-xL, Bax and Bid. In: Biochemistry (USA) 43(34), 2004. pp. 10930-10943.


Selected projects

  • DFG Forschungsgruppe, 2014 – 2017

  • ERC Starting Grant, 2013 – 2018

  • BMBF Nachwuchsgruppe Nanobiotechnologie, 2010 – 2015

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News

  1. Understanding Programmed Cell Death

    Researchers from the University of Tübingen, headed by Prof. Ana García-Sáez, studied membrane pores that are crucial for starting apoptosis.