Short CV/Education and training

  •  
    Primary school, gymnasium (grammar school) in Hannover, Germany; awarded the Abitur (A-levels) with top marks (1,0)

  • 1983 – 1989
    Studied biochemistry at the University of Hannover; Diplom degree, thesis titled: "Group separation of proteins for the diagnosis of tubular nephropathies"

  • 1992
    Doctor of Natural Science (Dr. rer. nat.), University of Hannover, dissertation titled "Isolation and chemical characterisation of beta-trace protein from human cerebrospinal fluid: Identification as prostaglandin-D synthase"

  • 1993 – 1996
    Research associate, German Research Centre for Biotechnology (GBF), Braunschweig, Germany

  • 1996 – 1998
    Research associate, Department of Cardiothoracic and Vascular Surgery, Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Medical University Hannover (MHH)

  • 1998 – 2009
    Research associate, GBF (later renamed the Helmholtz Centre for Infection Research), Braunschweig (director of research)

  • 2007
    Habilitation (postdoctoral qualification) and venia legendi (authorisation to teach) in regenerative medicine at MHH, thesis titled: "Mechanisms of mesenchymal cell differentiation under normal and inflammatory conditions: New therapeutic perspectives on disorders of the skeletal system"

  • 2009 – 2014
    Professor (W2) of biology of the locomotor system, Trauma Department (endowed professorship), MHH

  • since 2014
    Research associate and head of the research group "Graded implants and regenerative strategies", Orthopaedic Clinic, MHH

  • 2015
    Appointed adjunct professor, MHH

  • since 2015
    Spokesperson for the German Research Foundation (DFG) Research Unit 2180: "Graded implants for tendon-bone junctions", MHH – Leibniz University Hannover (LUH) – Braunschweig University of Technology (TU-Bs)

Selected publications

  • Hoffmann A, Wurster U, Nimtz M, Conradt HS. Carbohydrate Structures of β-Trace Protein from Human Cerebrospinal Fluid: Evidence for "Brain-Type" N-Glycosylation. J Neurochem. 1994;63(6):2185-96

  • Hoffmann A, Preobrazhenska O, Wodarczyk C, Medler Y, Winkel A, Shahab S, Huyle¬broeck D, Gross G, Verschueren K. TGF-β activated kinase-1 (TAK1), a MAP3K, interacts with Smad proteins and interferes with osteoge¬nesis in murine mesenchymal progenitors. J Biol Chem. 2005;280(29):27271-83

  • Hoffmann A*, Pelled G*, Turgeman G, Eberle P, Zilberman Y, Shinar H, Keinan-Adamsky K, Winkel A, Shahab S, Navon G, Gross G, Gazit D. Neotendon Formation Induced by Manipulation of the Smad8 Signaling Pathway in Mesenchymal Stem Cells. J Clin Invest. 2006;116(4):940-52

  • Shahab-Osterloh S*, Witte F*, Hoffmann A*, Winkel A, Laggies S, Neumann B, Seiffart V Lin¬denmaier W, Gruber AD, Ringe J, Häupl T, Thorey F, Willbold E, Corbeau P, Gross G. Mesenchymal Stem Cell-Dependent Formation of Heterotopic Tendon-Bone Insertions/ Osteotendinous Junctions. Stem Cells. 2010;28(9):1590-601

  • Courties G, Seiffart V, Presumey J, Escriou V, Scherman D, Zwerina J, Ruiz G, Zietara N, Ja¬blonska J, Weiss S, Hoffmann A, Jorgensen C, Apparailly F, Gross G. In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells. Blood. 2010;116(18):3505-16

  • Schäck LM, Noack S, Winkler R, Wißmann G, Behrens P, Wellmann M, Jagodzinski M, Krettek C, Hoffmann A. The phosphate source influences gene expression and quality of mineralization during in vitro osteogenic differentiation of human mesenchymal stem cells. PLoS One. 2013;8(6):e65943

  • Schäck LM, Noack S, Weist R, Jagodzinski M, Krettek C, Büttner M*, Hoffmann A*. Analysis of surface protein expression in human bone marrow stromal cells: new aspects of culture-induced changes, inter-donor differences and intracellular expression. Stem Cells Dev. 2013; 22(24):3226-35

  • Noack S*, Seiffart V*, Willbold E, Laggies S, Winkel A, Shahab-Osterloh S, Flörkemeier T, Hertwig F, Steinhoff C, Nuber UA, Gross G*, Hoffmann A*. Periostin secreted by mesenchymal stem cells supports tendon formation in an ectopic mouse model. Stem Cells Dev 2014; 23(16):1844-1857

  • Pogozhykh O, Pogozhykh D, Neehus A-L, Hoffmann A, Blasczyk R, Müller T. Molecular and cellular characteristics of human and non-human primate multipotent stromal cells from the amnion and bone marrow during long term culture. Stem Cell Res Ther. 2015;6:150

  • Saran S*, Tran DDH*, Ewald F, Koch A, Hoffmann A, Koch M, Nashan B, Tamura T. Depletion of three combined THOC5, mRNA export protein target genes synergistically induces human hepatocellular carcinoma cell death. Oncogene. 2015. doi: 10.1038/onc.2015.433. [Epub ahead of print]


Selected projects

  • German Research Foundation (DFG) subproject HO 2058/10-1: Optimization of electrodes for neuronal prosthesis. Collaborative partners: Prof. Boris Chichkov, Laser Zentrum Hannover (LZH); Prof. Anaclet Ngezahayo, LUH

  • DFG HO 2058/ 13-1: Establishment of an implant-bound alginate-matrix for cell-mediated neuronal protection. Collaborative partners: Dr. Verena Scheper, MHH; Prof. Heiko Zimmermann, Fraunhofer Institute for Biomedical Engineering (IBMT), St. Ingbert

  • DFG HO 2058/ 15-1: Biology and function of signaling factors BMP2, TGF-β1/3, Smad8 L+MH2.

  • DFG HO 2058/ 16-1: Quantification of activity and release of the signaling factors BMP2, TGF-β1/3. Collaborative partner: Prof. Heike Bunjes, TU-BS.

Membership in scientific bodies/juries

  • Reviewer for journals (e.g. EMBO Journal, Nephron, Journal of Neurochemistry, Pharmacology, Stem Cells, Stem Cells and Development, Advanced Drug Delivery Reviews), for the German Research Foundation (DFG), the Humboldt Foundation, University of Missouri

Additional qualifications

  • Continuing education for safety officers in genetic engineering safety, head of genetic engineering projects (safety levels 1 and 2)

  • Reviewer for journals, for the Alexander von Humboldt Foundation, the German Research Foundation (DFG), the University of Missouri


Soft Skills/Other activities and achievements

Other activities and achievements/family

  • Cockatiels, painting


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