Short CV/Education and training

  • 1971 – 1976
    Studied biology at the University of Würzburg, Germany; Diplom degree in biology

  • 1979
    Doctor of Natural Science (Dr. rer. nat.), Institute for Microbiology, University of Würzburg

  • 1979 – 1983
    Research associate, Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, USA

  • 1983 – 1997
    Research associate and Group Leader at the Max Planck Institute for Biochemistry (Department of Cell Biology)

  • 1988
    Habilitation (postdoctoral qualification, Dr. rer. nat. habil.) in the biology faculty, LMU Munich, Germany

  • 1997
    C4 professor, Institute for Biochemistry I, Medical Faculty at the University of Cologne, Germany

Selected publications

  • Noegel, A., Witke, W., Schleicher, M.: Calcium-sensitive non-muscle alpha-actinin contains EF-Hand structures and highly conserved regions. In: FEBS Lett. 221, 1987. S. 391-396.

  • Witke, W., Nellen, W., Noegel, A.: Homologous recombination in the Dictyostelium alpha-actinin leads to an altered mRNA and lack of the protein. In: EMBO J. 6, 1987. S. 4143-4148.

  • Noegel, A.A. et al.: The Dictyostelium gelation factor shares a putative actin-binding site with alpha-actinins and dystrophins and also has a rod domain containing six 100-residue motifs that appear to have a cross-beta conformation. In: J. Cell Biol. 109, 1989, S. 607-618.

  • Witke, W., Schleicher, M., Noegel, A.A.: Redundancy in the microfilament system: Dictyostelium cells that lack two F-actin crosslinking proteins show abnormal multicellular development. In: Cell 68, 1992. S. 53-62.

  • Fucini, P. et al.: The repeating segments of the F-actin cross-linking gelation factor (ABP-120) have an immunoglobulin-like fold. In: Nature Struct. Biol. 4, 1997. S. 223-230.

  • Zhen, Y.-Y. et al.: NUANCE, a giant protein connecting nucleus and actin cytoskeleton. In: J. Cell Sci. 115, 2002. S. 3207-3222.

  • Eichinger, L. et al.: The genome of the social amoeba Dictyostelium discoideum. In: Nature 435, 2005. S. 43-57.

  • Xiong, H. et al.: Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability. In: Traffic 9, 2008. S. 708-724.

  • Lüke, Y. et al.: Nesprin-2 Giant / NUANCE maintains nuclear envelope architecture and composition in skin. In: J. Cell Sci. 121, 2008. S. 1887-1898.

  • Mondal, S. et al.: Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions. In: J. Cell Biol. 181, 2008. S. 747-760.

  • Heidel, A. et al.: Phylogeny-wide analysis of social amoeba genomes highlights ancient origins for complex intercellular communication. Genome Res. 21. 2011. S 1882-1891.

  • Rashmi, R.N. et al.: The nuclear envelope protein Nesprin-2 has roles in cell proliferation and differentiation during wound healing. Nucleus 3. 2012. PMID: 22198684.

  • Chang, G.S. et al.: Unusual combinatorial involvement of poly-A/T tracts in organizing genes and chromatin in Dictyostelium. Genome Res. 2012. PMID: 22434426.

Selected projects

  • Structure and function of the actin cytoskeleton

  • Components of the nuclear membrane

  • Comparative genomics of social amoebas

Membership in scientific bodies/juries

  • Deputy chair of the Finance and Budget Commission of the Medical Faculty at the University of Cologne

  • Member of the doctoral committee of the Medical Faculty at the University of Cologne

  • Member of the executive board of the Centre for Molecular Medicine at the University of Cologne (ZMMK)

  • Advisory board of VBIO (Division for biology, life sciences and biomedicine in Germany), since 2009

  • Member of the European Molecular Biology Organisation (EMBO), since 2000

  • Advisor to the German Research Foundation (DFG) for cell biology – microbiology panel, 2000 – 2008


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