Short CV/Education and training

    Undergraduate and doctoral studies at the University of Cologne, the University of Freiburg and the University of Konstanz, Germany

    Research associate at Scripps Research Institute in California, USA

  • Since 1997
    Research associate at the Institute of Hygiene in Düsseldorf, Germany

  • Since 2001
    Research associate at the Environmental Health Research Institute (IUF) of Heinrich Heine University (HHU) Düsseldorf

    Professor by special appointment in the Faculty of Mathematics and Natural Science, HHU Düsseldorf

    Visiting researcher at the Leibniz Institute for Age Research in Jena, Germany

Selected publications

  • von Mikecz, A. et al.: CBP/p300 and RNA-polymerase II colocalize in transcriptionally active domains in the nucleus. In: J. Cell Biol. 150, 2000. S. 265-274.

  • Chen, M., von Mikecz, A.: Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2-nanoparticles. In: Exp. Cell Res. 305, 2005. S. 51-62.

  • Rockel, T.D., Stuhlmann, D., von Mikecz, A.: Proteasomes degrade proteins in focal subdomains of the human cell nucleus. In: J. Cell Sci. 118, 2005. S. 5231-5242.

  • von Mikecz, A.: The nuclear ubiquitin-proteasome system (nUPS). In: J. Cell Sci. 119, 2006. S. 1977-1984.

  • Chen, M. et al.: Nuclear polyglutamine-containing protein aggregates as active proteolytic centers. In: J. Cell Biol. 180, 2008. S. 697-704.

  • von Mikecz, A.: PolyQ-fibrillation in the cell nucleus: who's bad? In: Trends Cell Biol. 19, 2009. S. 685-691.

  • Chen, M., von Mikecz, A.: Nanoparticle-induced cell culture models for neurodegenerative protein aggregation diseases. In: Inhalation Toxicol. 21(S1), 2009. S. 110-114.

  • von Mikecz, A.: Zwerge mit Durchschlagskraft – Segen und Fluch der Nanopartikel. In: Gehirn und Geist 03/2010: S. 58-62, hg. von Spektrum der Wissenschaft, Heidelberg.

Selected projects

  • Nanoparticle-mediated neurodegeneration

  • Molecular mechanisms of neurodegenerative proteinopathies

  • The role of the nuclear ubiquitin-proteasome system in the functional organisation of the cell nucleus

  • Characterisation of protein fibrillation /fibrils in the cell nucleus

Membership in scientific bodies/juries

  • American Society of Cell Biology (ASCB)

  • Committee of the Wilhelm Bernhard Workshop: Nuclear structure and function

  • German Society for Cell Biology (DGZ)

  • International Society of Histochemistry

  • Competence Network for Rheumatic Diseases (MedNet)

  • German Network for Systemic Scleroderma (DNSS)

Additional qualifications

Teaching / guest lectures:

  • University of Lausanne, Switzerland

  • University of Southern California San Diego (UCSD), USA

Soft Skills/Other activities and achievements

Additional interests

  • Preservation of historic monuments

Soft Skills

  • Interdisciplinarity


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