Short CV/Education and training

  •  
    Undergraduate and doctoral studies at the University of Cologne, the University of Freiburg and the University of Konstanz, Germany

  •  
    Research associate at Scripps Research Institute in California, USA

  • Since 1997
    Research associate at the Institute of Hygiene in Düsseldorf, Germany

  • Since 2001
    Research associate at the Environmental Health Research Institute (IUF) of Heinrich Heine University (HHU) Düsseldorf

  •  
    Professor by special appointment in the Faculty of Mathematics and Natural Science, HHU Düsseldorf

  •  
    Visiting researcher at the Leibniz Institute for Age Research in Jena, Germany

Selected publications

  • von Mikecz, A. et al.: CBP/p300 and RNA-polymerase II colocalize in transcriptionally active domains in the nucleus. In: J. Cell Biol. 150, 2000. S. 265-274.

  • Chen, M., von Mikecz, A.: Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2-nanoparticles. In: Exp. Cell Res. 305, 2005. S. 51-62.

  • Rockel, T.D., Stuhlmann, D., von Mikecz, A.: Proteasomes degrade proteins in focal subdomains of the human cell nucleus. In: J. Cell Sci. 118, 2005. S. 5231-5242.

  • von Mikecz, A.: The nuclear ubiquitin-proteasome system (nUPS). In: J. Cell Sci. 119, 2006. S. 1977-1984.

  • Chen, M. et al.: Nuclear polyglutamine-containing protein aggregates as active proteolytic centers. In: J. Cell Biol. 180, 2008. S. 697-704.

  • von Mikecz, A.: PolyQ-fibrillation in the cell nucleus: who's bad? In: Trends Cell Biol. 19, 2009. S. 685-691.

  • Chen, M., von Mikecz, A.: Nanoparticle-induced cell culture models for neurodegenerative protein aggregation diseases. In: Inhalation Toxicol. 21(S1), 2009. S. 110-114.

  • von Mikecz, A.: Zwerge mit Durchschlagskraft – Segen und Fluch der Nanopartikel. In: Gehirn und Geist 03/2010: S. 58-62, hg. von Spektrum der Wissenschaft, Heidelberg.


Selected projects

  • Nanoparticle-mediated neurodegeneration

  • Molecular mechanisms of neurodegenerative proteinopathies

  • The role of the nuclear ubiquitin-proteasome system in the functional organisation of the cell nucleus

  • Characterisation of protein fibrillation /fibrils in the cell nucleus

Membership in scientific bodies/juries

  • American Society of Cell Biology (ASCB)

  • Committee of the Wilhelm Bernhard Workshop: Nuclear structure and function

  • German Society for Cell Biology (DGZ)

  • International Society of Histochemistry

  • Competence Network for Rheumatic Diseases (MedNet)

  • German Network for Systemic Scleroderma (DNSS)

Additional qualifications

Teaching / guest lectures:

  • University of Lausanne, Switzerland

  • University of Southern California San Diego (UCSD), USA


Soft Skills/Other activities and achievements

Additional interests

  • Preservation of historic monuments


Soft Skills

  • Interdisciplinarity


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