Short CV/Education and training

  • 1985 – 1990
    Studied biochemistry/molecular biology, Department of Biology, Humboldt University of Berlin, Germany

  • 1990
    Diplom thesis written at the Institute of Biochemistry (Charité), Humboldt University of Berlin

  • 1991 – 1995
    Doctorate (Doctoral of Natural Science, Dr rer. nat.), Department of Biology, in the Institute of Biochemistry (Charité), Humboldt University of Berlin

  • 1995 – 2001
    Postdoctoral Fellow at the European Molecular Biology Laboratory, Heidelberg, Germany

  • 2001 – 2003
    Principal scientist and head of a research group, Anadys Pharmaceuticals Europe, Heidelberg

  • 2003 – 2004
    Research associate at the Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg

  • 2005
    Habilitation (postdoctoral qualification) and received the venia legendi (authorisation to teach) for the subject biochemistry at Martin Luther University Halle-Wittenberg, Germany

  • 2005 – 2009
    Head of an independent research group (Heisenberg Fellowship) at the Institute of Biochemistry and Biotechnology, Martin Luther University Halle-Wittenberg

  • Since 2009
    Second appointment as member of the Faculty of Mathematics, Computer Science and Natural Sciences at RWTH Aachen University, Germany

  • Since 2009
    Head of the functional area Research (Heisenberg Fellowship until 2009), Clinical Department of Surgical Intensive Care – Adults, University Hospital Aachen, RWTH Aachen University

  • Since 2011
    associate professor at the Medical Department of the University Aachen

Selected publications

  • Naarmann, I.S., Harnisch, C., Müller-Newen, G., Urlaub, H., Ostareck-Lederer, A. and Ostareck, D.H.: DDX6 recruits translational silenced human reticulocyte 15-lipoxygenase mRNA to RNP granules. In: RNA, 16, 2010. pp. 2189-2204.

  • Weinlich, S., Ostareck-Lederer, A., Ostareck, D.H.: IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3'UTR. In: RNA 15, 2009. pp. 1528-1542.

  • Naarmann, I. et al.: mRNA silencing in human erythroid cell maturation: hnRNP K controls the synthesis of its regulator c-Src. In: J. Biol. Chem. 283, 2008. pp. 18461-18472.

  • Adolph, D. et al.: Deciphering the crosstalk between hnRNP K and c-Src: The c-Src activation domain in hnRNP K is distinct from the site of interaction. In: Mol. Cell. Biol. 27, 2007. pp. 1758-1770.

  • Messias, A. et al.: The DICE-binding activity of KH domain 3 of hnRNP K is affected by c-Src mediated tyrosine phosphorylation. In: J. Mol. Biol. 361, 2006. pp. 470-481.

  • Ostareck-Lederer, A. et al.: Asymmetric arginine dimethylation of hnRNP K by PRMT1 inhibits its interaction with c-Src. In: J. Biol. Chem. 281, 2006. pp. 11115-11125.

  • Ostareck-Lederer, A. et al.: c-Src-mediated phosporylation of hnRNP K drives translational activation of specifically silenced mRNAs. In: Mol. Cell. Biol. 22, 2002. pp. 4535-4543.

  • Ostareck, D.H. et al.: Lipoxygenase mRNA silencing in erythroid differentiation: The 3'UTR regulatory complex controls 60S ribosomal subunit joining. In: Cell 104, 2001. pp. 281-290.

  • Habelhah, H. et al.: Erk phosphorylation is required for nuclear export of hnRNP K and subsequent inhibition of mRNA translation. In: Nat. Cell Biol. 3, 2001. pp. 325-330.

  • Ostareck, D.H. et al.: mRNA silencing during erythroid differentiation: hnRNP K and hnRNP E1 regulate lipoxygenase translation from the 3-end. In: Cell 89, 1997. pp. 597-606. (equal contribution)

  • Ostareck-Lederer, A. et al.: Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3' untranslated region. In: EMBO J. 13(6), 1994. pp. 1476-1481.


Selected projects

  • German Research Foundation (DFG) Research Unit FOR 855: Cytoplasmic regulation of gene expression, Project OS 290/3-1, 3-2 Translational control of gene expression in maturing erythroid cells

  • DFG Individual Grants Programme OS 290/4-1

  • Characterization of cellular factors that modulate VEGF-IRES-dependent translation initiation

  • START-Programme UK Aachen

  • IZKF Aachen E6-4

    Identification of translational regulated mRNAs in inflammation and sepsis

Additional qualifications

  • Visiting researcher at the Department of Medicine, University of Washington, Seattle, USA, 1999

  • Visiting researcher at the European Molecular Biology Laboratory (EMBL), Heidelberg, Germany, 1994

  • Visiting researcher at the Institute of Biochemistry, University of Cambridge, UK, 1992 – 1993


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