Short CV/Education and training

  • 1985 – 1988
    Gymnasiale Oberstufe Goetheschule Wetzlar, Germany (Abitur)

  • 1988 – 1991
    Study of Biology, Justus Liebig University, Giessen, Germany (bachelor's degree)

  • 1991 – 1995
    Study of Biology, University of Utrecht, Utrecht, The Netherlands; main subject: Molecular and Chemical Biology (masters degree, cum laude [=best 10%], 23-01-1995)

  • 1995 – 1999
    Doctorate study (PhD), University of Utrecht, Utrecht, The Netherlands, Laboratory for Physiological Chemistry (Thesis: Rap and Ral in platelet signaling, 22-04-1999; promotores Prof. Dr. J.L. Bos and Prof. Dr. J.W. Akkerman)

  • 1999 – 2003
    Postdoc projects, Department of Human Genetics, Radboud university medical center, Nijmegen, The Netherlands

  • 2004 – 2008
    Assistant Professor in Genetics of Multifactorial Diseases, Departments of Human Genetics and Psychiatry, Radboud university medical center

  • 2009 – 2011
    Associate Professor of Molecular Psychiatry, Departments of Human Genetics and Psychiatry, Radboud university medical center

  • since 2012
    Full Professor of Molecular Psychiatry, Departments of Human Genetics and Psychiatry, Radboud university medical center

  • Please find a complete CV at: www.ru.nl/people/donders/franke-b/

Selected publications

  • Poelmans G, Franke B, Glennon J, Pauls DL, Buitelaar JK (2013). AKAPs integrate genome-wide association study findings for autism spectrum disorders. Translational Psychiatry 3, e270

  • Bralten J, Franke B, Waldman ID, Rommelse NNJ, Neale B, Asherson P, Banaschewski T, Ebstein R, Gill M, Miranda A, Oades RD, Roeyers H, Rothenberger A, Sergeant J, Sonuga-Barke E, Steinhausen HC, Faraone SV, Buitelaar JK#, Arias-Vasquez A# (#shared final responsibility) (2013). Genetic pathways for ADHD show association to hyperactive/impulsive symptoms. J Am Acad Child Adolesc Psychiatry 52 (11), 1204-1212 [Epub 2013 Sep 5]

  • Den Ouden H, Fernandez G , Elshout J, Rijpkema M, Hoogman, M, Franke B, Cools R (2013). Dissociable effects of dopamine and serotonin on reversal learning. Neuron 80 (4), 1090-1100

  • Stein JL*, Medland SE*, Arias Vasquez A*, Hibar DP*, Senstad RE, Winkler AM, Toro R, Appel K, Bartecek R, Bergmann Ø, Bernard M, Brown AA, Cannon DM, Chakravarty M, Christoforou A, Domin M, Grimm O, Hollinshead M, Holmes AJ, Homuth G, Hottenga JJ, Langan C, Lopez LM, Hansell NK, Hwang KS, Kim S, Laje G, Lee PH, Liu X, Loth E, Lourdusamy A, Muñoz Maniega S, Mattingsdal M, Mohnke S, Nho K, Nugent AC, O?Brien C, Papmeyer M, Pütz B, Ramasamy A, Rijpkema M, Risacher SL, Rose EJ, Ryten M, Shen L, Sprooten E, Strengman E, Teumer A, Trabzuni A, van Eijk K, van Erp TGM, van Tol MJ, Wittfeld K, Wolf C, Woudstra S, Aleman A, Alhusaini S, Almasy L, Binder EB, Brohawn DG, Cantor RM, Carless MA, Corvin A, Czisch M, Curran JE, Davies G, Delanty N, Depondt C, Duggirala R, Dyer TD, Erk S, Fagerness J, Fox PT, Freimer NB, Gill M, Göring HHH, Hoehn D, Holsboer F, Hoogman M, Johnson MP, Kasperaviciute D, Kent, Jr., JW, Kochunov P, Lancaster JL, Lawrie SM, Liewald DC, Mandl R, Matarin M, Mattheisen M, Meisenzahl E, Melle I, Moses EK, Mühleisen TW, Nauck M, Nöthen MM, Olvera RL, Pandolfo M, Pike GB, Puls R, Reinvang I, Rentería ME, Rietschel M, Roffman JL, Royle NA, Rujescu D, Savitz J, Schnack HG, Schnell K, Seiferth N, Smith C, Steen VM, Valdés Hernández MC, Van den Heuvel M, van der Wee NJ, Van Haren NEM, Veltman JA, Völzke H, Walker R, Agartz I, Boomsma DI, Cavalleri GL, Dale AM, Djurovic S, Drevets WC, Hagoort P, Hall J, Heinz A, Jack Jr CR, Foroud TM, Le Hellard S, Macciardi F, Montgomery GW, Poline JB, Porteous DJ, Sisodiya SM, Starr JM, Sussmann J, Toga AW, Veltman DJ, Walter H, Weiner MW, the Alzheimer?s Disease Neuroimaging Initiative, IMAGEN Consortium, Saguenay Youth Study Group, Bis JC, Ikram MA, Smith AV, Tzourio C, Vernooij MW, Launer LJ, DeCarli C, Seshadri S, for the CHARGE Consortium, Andreassen OA, Apostolova LG, Bastin ME, Blangero J, Brunner HG, Buckner RL, Cichon S, Coppola G, de Zubicaray GI, Deary IJ, Donohoe G, de Geus EJC, Espeseth T, Fernández G, Glahn DC, Grabe HJ, Hardy J, Jenkinson M, Kahn RS, McDonald C, McIntosh AM, McMahon FC, McMahon KL, Meyer-Lindenberg A, Morris DW, Müller-Myhsok B, Nichols TE, Ophoff RA, Paus T, Pausova Z, Penninx BW, Hulshoff Pol HE, Potkin SG, Sämann PG, Saykin AJ, Schumann G, Smoller JW, Wardlaw JW, Weale ME, Martin NG#, Franke B#, Wright MJ#, Thompson PM#, for the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium (2012). Common genetic polymorphisms are associated with human hippocampal and intracranial volumes. Nature Genetics 44 (5), 5552-5561 [Epub 2012 April 15]

    (*equal contribution; #shared final responsibility)

  • Franke B, Faraone SV, Asherson P, Buitelaar J, Bau CHD, Ramos-Quiroga JA, Mick E, Grevet EH, Johansson S, Haavik J, Lesch KP, Cormand B, Reif A, on behalf of the International Multicentre persistent ADHD CollaboraTion, IMpACT (2012). The genetics of attention deficit/hyperactivity disorder (ADHD) in adults, a review. Mol Psychiatry, invited review, 17 (10), 960-987 [Epub Nov 22 2011]

  • Williams NM*, Franke B*, Mick E, Anney RJL, Freitag CM, Gill M, Thapar A, O'Donovan MC, Owen MJ, Holmans P, Kent L, Middleton F, Zhang-James Y, Liu L, Meyer J, Trang Nguyen T, Romanos J, Romanos M, Seitz C, Renner TJ, Walitza S, Warnke A, Palmason H, Buitelaar J, Rommelse N, Arias Vasquez A, Hawi Z, Langley K, Sergeant J, Steinhausen HC, Roeyers H, Biederman J, Zaharieva I, Hakonarson H, Elia J, Lionel AC, Crosbie J, Marshall CR, Schachar R, Scherer S, Todorov A, Smalley SL, Loo S, Nelson S, Shtir C, Asherson P, Reif A, Lesch KP, Faraone SV (2012). Genome-wide analysis of copy number variants in attention deficit / hyperactivity disorder confirms the role of rare variants and implicates duplications at 15q13.3. (*equal contribution) Am J Psychiatry, 169 (2), 195-204 [Epub 2011 Dec 15]

  • Hoogman M, Aarts E, Zwiers M, Slaats-Willemse D, Naber M, Cools R, Kan C, Buitelaar JK, Franke B (2011). Reward-related activity in the striatum and impulsivity vary with Nitric Oxide Synthase genotype in Attention Deficit/Hyperactivity Disorder patients and healthy subjects. Am J Psychiatry 168 (10), 1099-1106 [Epub 2011 Jul 1]

  • Poelmans G, Pauls D, Buitelaar JK, Franke B (2011). Integrated genome-wide association findings identify a neurodevelopmental network for attention deficit hyperactivity disorder (ADHD). Am J Psychiatry, 168 (4), 365-377 [Epub 2011 Feb 15]

  • Poelmans G, Buitelaar JK, Pauls D, Franke B (2011). A theoretical molecular network for dyslexia: integrating available genetic findings. Mol Psychiatry, 16 (4), 365-382 [Epub 2010 Oct 19]



Complete list of publications

Selected projects

  • Research grant provided by the European Commission Framework Program 7 (general coordinator and workpackage leader); 2013. Title: Aggression subtyping for improved insight and treatment innovation in psychiatric disorders – Aggressotype. We study the causes of and mechanisms behind aggression as observed in child psychiatric disorders ADHD and conduct disorder (www.aggressotype.eu)

  • Personal Vici Research grant from the Dutch Organisation for Scientific Research (NWO); 2013. We use exome sequencing in 500 samples of patients with the most severe, persistent form of ADHD. Bioinformatics, animal models (Drosophila melanogaster) and cognomics/imaging genetics approaches are used to characterize the networks and biological mechanisms leading from gene to disease.

  • Research grant provided by the European Commission Framework Program 7 (workpackage leader); 2013. Title: IMAGEMEND. We focus on the development of effective neuroimaging tools for diagnosis, monitoring and management of mental disorders. (www.imagemend.eu)

  • Research grant provided by the European Commission Framework Program 7 (workpackage leader); 2012. Title: Translational Adolescent and Childhood Therapeutic Interventions in Compulsive Syndromes = TACTICS. Using combined network analysis for brain-based, cognitive and behavioural traits as well as compulsivity-related disorders, we identify novel genes for pathological compulsivity and test those for prediction of disease and treatment. (www.tactics-project.eu)

  • Research grant provided by the Brain & Cognition Excellence Program of the Dutch Organisation for Scientific Research (NWO); 2010. Title: From genetic pathways to cognition in ADHD: a question of the right connections? We perform cognomics/imaging genetics analyses in adult ADHD patients and healthy individuals to characterize, how genes related to neurite outgrowth lead to ADHD and related traits.

Membership in scientific bodies/juries

UNIVERSITY:

  • Member of the top staff committee of the Radboud university medical centre

  • Principal Investigator, Radboud university medical centre

  • Principal Investigator, Donders Institute for Brain, Cognition and Behavior of the Radboud University

  • Official representative (speaker) of the "Plasticity and Memory" Theme of the Donders Institute for Brain, Cognition and Behavior (since 2011)

  • Leader of Radboudumc Research Theme "Neurodevelopmental disorders" (since 2014)

  • Member of Research Council of the Radboudumc

  • Member of the Research Quality Committee evaluating Principal Investigators at Radboudumc (2014-2016)

NATIONAL/INTERNATIONAL CONSORTIA:

  • Coordinator of the Aggressotype Consortium (EU-funded consortium investigating aggression in ADHD and conduct disorder)

  • Coordinator of the International Multicentre persistent ADHD CollaboraTion (IMpACT)

  • Chair of the Cognomics Program in Nijmegen and PI of the Brain Imaging Genetics (BIG) Study

  • Member of the management team of the international ENIGMA (Enabling NeuroImaging Genetics through Meta-Analysis) consortium (http://enigma.ini.usc.edu/)

  • Member of steering committee of NWO Dutch Dyslexia Program (http://www.nwo.nl/ nwohome.nsf/pages/NWOA_6NZHH9; till 2012)

  • Member of the management team of the Nijmegen Biomedical Study (http://www.nijmegenbiomedischestudie.nl/)

  • Member of the Psychiatric GWAS Consortium (PGC) (https://pgc.unc.edu/index.php)

  • Member of the International ADHD Molecular Genetics Network (http://adhdnet.com/wp/)

PROFESSIONAL (INTER)NATIONAL SOCIETIES:

  • Elected member of the European Network for Hyperkinetic Disorders (Eunethydis)

    >Member of Scientific Program Committee for annual meeting 2013

  • Member of the International Society of Psychiatric Genetics (ISPG)

    >Member of Scientific Program Committee for World Congress of Psychiatric Genetics 2013 (Boston), 2014 (Copenhagen), 2015 (Toronto)

  • Member of the European College of Neuropsychopharmacology (ECNP)

  • Member of the ADHD World Federation

    >Member of Scientific Program Committee 2015 (Glasgow)

  • Member of the Society for Neuroscience (SfN)

  • Member of the Netherlands Society of Human Genetics (NVHG)

  • Member of the Dutch Biobanking initiative BBMRI-NL

REVIEWING ACTIVITIES:

  • Associate editor of the American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

  • Member of Editorial Advisory Board of The Lancet Psychiatry

  • Member of External Reviewer Panel of the Dutch Brain Foundation (Nederlandse Hersenstichting)

  • Guest editor for special issue on adult ADHD for the European Neuropsychopharmacology Journal (2012)

  • Member of the Eunethydis Sagvolden Junior Travel Scholarship committee

  • Member of the editorial advisory board for the Radboud University magazine VOX

  • Member of Donders Centre for Neuroscience Grant Evaluation Committee (2008-present)

  • Ad hoc reviewer for several international scientific journals in the fields of Genetics and Psychiatry: The Lancet, Nature, Nature Genetics, Proceedings of the National Academy of Sciences USA, Molecular Psychiatry, Biological Psychiatry, Archives of General Psychiatry, Human Molecular Genetics, Journal of Neuroscience, Journal of the American Association of Child and Adolescent Psychiatry, Neuropsychopharmacology, European Child and Adolescent Psychiatry, American Journal of Medical Genetics Part B, Birth Defects Research Part A, Human Mutation, Journal of Child Psychology and Psychiatry, BMC Medical Genetics, European Journal of Human Genetics, International Journal of Neuropsychopharmacology, Psychopharmacology, Human Genetics, Biological Psychology, Human Brain Mapping, NeuroIMAGE, PLOS One, BMC Psychiatry.

  • Reviewer of project proposals for several national and international funding agencies, among which: Dutch NWO Verniewingsimpuls, Action Medical Research (UK), Medical Research Council, MRC (UK), Telethon (Italy), Deutsche Forschungsgemeinschaft (DFG, Germany), Research Council of Norway, National Health & Medical Research Council (NHMRC, Australia), Agence Nationale de la Recherche (ANR, France), EU Framework Program 7, EU Horizon 2020 Programme, EU Human Brain Project.

Media coverage

  • Interviews for popular press (daily newspapers, popular psychology magazines) (since 2008)

  • Interviews for newsletters of Dutch patient/parent organizations Woortblind (dyslexia), Impuls (ADHD) and Balans (neurodevelopmental disorders) (since 2008)

  • Press conference (+ television interview) for the European College of Neuropsychopharmacology Meeting, Istanbul, Turkey: Genetics of adult ADHD. September 2009

  • National Dutch TV program "Pavlov" on ADHD, December 2011 (http://www.wetenschap24.nl/programmas/pavlov/tv/afleveringen/seizoen-2/tygo-gernandt.html)

  • National Dutch TV program "Pavlov" on dyslexia, March 2012 (http://www.wetenschap24.nl/programmas/pavlov/tv/afleveringen/seizoen-3/Egbert-Jan-Weeber.html)

  • Radio interviews for regional radio (2012-2014)

  • Public Day of the Brain Foundation Netherlands 2013. Dyslexie: van gen naar brein. October 2013

Additional qualifications

  • Head of the Researchlab for Multifactorial Diseases, Department of Human Genetics, Radboud University Nijmegen Medical Centre, since 2001

  • Principal Investigator, Donders Institute for Brain, Cognition and Behaviour, since 2008

  • Official speaker of the 'Plasticity & Memory'Theme of the Donders Institute for Brain, Cognition and Behaviour, since 2011

  • Official coordinator of the 'Neurodevelopmental Disorders' Radboud Research Theme of the Radboudumc, since 2014


Soft Skills/Other activities and achievements

Soft Skills

  • I take part in mentoring programs for female as well as male young scientists. I mentor several females and males both locally and internationally.


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