Short CV/Education and training

  • 1971 – 1976
    Studied medicine at the University of Vienna, Austria

  • 1977 – 1983
    Specialist training in internal medicine in the Department of Medicine I at the General Hospital Vienna

  • 1983 – 1985
    Department of Medicine I at the General Hospital Vienna

  • 1985 – 1988
    Immunological research work at Charing Cross Sunley Research Centre, London, UK (now the Kennedy Institute for Rheumatology; director: Prof. Marc Feldmann)

  • 1989 – 1991
    Developed and directed an immunological research laboratory in the Department of Pathophysiology & Allergy Research at the University of Vienna

  • 1992 – 2003
    Director of the Immunology research group at the Institute for Biomedical Aging Research of the Austrian Academy of Sciences in Innsbruck, Austria

  • 1996
    Second Habilitation (postdoctoral qualification): Pathophysiology at the University of Innsbruck

  • 2003 – 2012
    Director of the Institute for Biomedical Aging Research of the Austrian Academy of Sciences in Innsbruck

  • Since 2012
    Director of the Research Institute for Biomedical Aging Research at the University of Innsbruck

  • Since 2013
    University professor of immunogerontology (§ 99), University of Innsbruck

Selected publications

  • Grubeck-Loebenstein, B. et al.: The pathogenetic relevance of HLA-class II expressing thyroid follicular cells in non toxic goitre and in Graves' disease. In: The Journal of Clinical Investigation 81, 1988. S. 1608-1614.

  • Grubeck-Loebenstein, B. et al.: Transforming growth factor beta regulates thyroid growth: Role in the pathogenesis of non toxic goitre. In: The Journal of Clinical Investigation 83, 1989. S. 764-770.

  • Grubeck-Loebenstein, B. et al.: Retrobulbar T cells from patients with Graves' ophthalmopathy are CD8+ and specifically recognize autologous fibroblasts. In: The Journal of Clinical Investigation 93, 1994. S. 2738-2743.

  • Steger, M.-M. et al.: Vaccination against tetanus in the elderly: Do recommended vaccination strategies give sufficient protection? In: The Lancet 348, 1996. S. 762.

  • Grubeck-Loebenstein, B. et al.: No immunity for the elderly. In: Nature Medicine 4, 1998. S. 870.

  • Blasko, I. et al.: TNFalpha plus IFNgamma induce the production of Alzheimer beta-amyloid peptides and decrease the secretion of APPs. In: The FASEB Journal 13, 1999. S. 63-68.

  • Saurwein-Teissl, M. et al.: Lack of antibody production following immunization in old age: Association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. In: The Journal of Immunology 168, 2002. S. 5893-5899.

  • Schwaiger, S. et al.: IL-4 producing CD8+ T cells with a CD62L++(bright) phenotype accumulate in a subgroup of older adults and are associated with the maintenance of intact humoral immunity in old age. In: The Journal of Immunology 170, 2003. S. 613-619.

  • Herndler-Brandstetter, D. et al.: CD25-expressing CD8+ T cells are potent memory cells in old age. In: The Journal of Immunology 175, 2005. S. 1566-1574.

  • Eisenberg, T. et al.: Induction of autophagy by spermidine promotes longevity. In: Nature Cell Biology 11, 2009. S. 1305-1314.

  • Weiskopf, D. et al.: Oxidative stress can alter the antigenicity of immunodominant peptides. In: Journal of Leukocyte Biology 87, 2010. S. 165-172.

  • Herndler-Brandstetter, D. et al.: Human bone marrow hosts polyfunctional memory CD4+ and CD8+ T cells with close contact to IL-15-producing cells. In: The Journal of Immunology 186, 2011. S. 6965-6971.



Complete list of publications

Selected projects

  • Discovered that iodine deficiency, despite cooking salt being supplemented with iodine, was the cause of epidemic bland goitre in Austria in the 1970s

  • Fundamental work on the pathogenesis of bland goitre

  • Proof for the first time of the autoimmune regulatory mechanisms involved in the development of bland goitre

  • Discovered the interaction between TGF-beta and iodine in the development of bland goitre

  • Fundamental work on the T-cell receptor repertoire and the role of cytokines in Graves' disease

  • Discovered the causal role of retro-orbital fibroblasts in the development of endocrine ophthalmopathy

  • Proof for the first time that cytokines stimulate the production of beta amyloid proteins in nerve cells in Alzheimer's

  • Discovered the mechanisms that lead to insufficient vaccine protection in old age

  • Groundbreaking work on changes in the T-cell repertoire in old age; definition of the role of the cytomegalovirus

  • Initial investigations into the adaptive immune system and bone marrow in old age; definition of the role of IL-15

Membership in scientific bodies/juries

  • Jury for the Science Prize from the State of Tyrol, Austria, since 2013

  • Member of the board of trustees of the Austrian Science Fund (FWF), 2011-2013

  • Founding member of and consultant to the Austrian Interdisciplinary Platform on Ageing (ÖPIA), since 2010

  • Member of the senate of the Christian Doppler Forschungsgesellschaft (research association – CDG), since 2009

  • Member of the advisory board on Geriatric Medicine to the Austrian Federal Ministry of Health (BMG), 2008-2014

  • Coordinator of the PhD programme "The Aging of Biological Communication Systems" at Innsbruck Medical University, 2002 – 2015

  • President and vice president of the Austrian Society for Allergology and Immunology (ÖGAI), 2002 – 2008

  • Member of the board of the Austrian Society for Allergology and Immunology (ÖGAI), 2000 – 2008

  • Member of the vaccination committee of the "Oberster Sanitätsrat" (expert medical advisory committee) of the Austrian Federal Ministry of Health (BMG), 1998 – 2010

  • Member of the board of the Austrian Society for Geriatrics and Gerontology (ÖGGG), 1997 – 2010

  • Member of the scientific advisory committee to the Research and Study Program on Geriatrics of the Robert Bosch Foundation (Stuttgart, Germany), 1988 – 2003

  • Member of the scientific advisory committee to "Fonds Gesundes Österreich" ("healthy Austria fund" – FGÖ), 1987 – 2003

Additional qualifications

  • Specialist in internal medicine and pathophysiology


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