Short CV/Education and training

  • 1992 – 1997
    Studied biochemistry at Leibniz University Hanover (LUH), Medical University of Hanover (MHH), Germany, and Swiss Federal Institute of Technology Zurich, Switzerland

  • 1997 – 2001
    PhD studies, Institute of Biochemistry, University of Zurich

  • 2001 – 2005
    Postdoc, IMB, Swiss Federal Institute of Technology Zurich

  • 2006 – 2007
    Research associate and lecturer at the Institute of Molecular Biology and Biophysics (IMB), Swiss Federal Institute of Technology Zurich

  • Since 2007
    Team leader for cryo-electron microscopy at the European Molecular Biology Laboratory (EMBL)

  • Since 2014 Professor of Biochemistry, University of Bristol (UK)

Selected publications

  • von Loeffelholz et al., Structural Basis of Signal Sequence Surveillance and Selection by the SRP-SR Complex. In: Nat. Struct. Mol. Biol., 20, 2013, 604-610.

  • Bieniossek et al., The architecture of human general transcription factor TFIID core complex. In: Nature 493, 2013, 699-702.

  • Estrozi et al., Structure of the E. coli Co-translational Targeting Complex in the Stable Early Conformation. In: Nat. Struct. Mol. Biol. 18, 2011, pp. 88-90.

  • Kohler, R. et al.: YidC and Oxa1 form dimeric insertion pores on the translating ribosome. In: Mol. Cell 34, 2009. pp. 344-353.

  • Zhang, X. et al.: Multiple conformational switches in a GTPase complex control co-translational protein targeting In: Proc. Natl. Acad. Sci. U.S.A. 106, 2009. pp. 1754-1759.

  • Bingel-Erlenmeyer, R. et al.: A peptide-deformylase complex reveals mechanism of nascent chain processing. In: Nature 452, 2008. pp. 108-111.

  • Schaffitzel, C. et al.: Structure of the E. coli signal recognition particle bound to a translating ribosome. In: Nature 444, 2006. pp. 503-506.

  • Mitra, K. et al.: Structure of the E. coli protein-conducting channel bound to a translating ribosome. In: Nature 438, 2005. pp. 318-324.

  • Berger, P. et al.: Membrane association of myotubularin-related protein 2 is mediated by a pleckstrin homology-GRAM domain and a coiled-coil dimerization module. In: Proc. Natl. Acad. Sci. U.S.A. 100, 2003. pp. 12177-12182.

  • Schaffitzel, C. et al.: In vitro generated antibodies specific for telomeric guanine-quadruplex DNA react with Stylonychia lemnae macronuclei. In: Proc. Natl. Acad. Sci. U.S.A. 98, 2001. pp. 8572-8577.

  • Hanes, J. et al.: Picomolar affinity antibodies from a fully synthetic naive library selected and evolved by ribosome display. In: Nature Biotechnol. 18, 2000. pp. 1287-1292.



Complete list of publications

Selected projects

  • Co-translational targeting and translocation

    membrane insertion by the holo-translocation machinery in E. coli

  • The mechanism of translational control by nonsense-mediated mRNA decay in mammalian cells

Membership in scientific bodies/juries

  • Scientific coordinator of the EIROforum Teachers' School organised by ESRF-ILL-EMBL, October 2011, Grenoble, Switzerland

  • Member of the biology committee, Institut Laue-Langevin (ILL), Grenoble, appointed 2010 – 2013

  • Treasurer, Chemistry Society of Zurich (CGZ), Switzerland, 2007

  • Representative for mid-level faculty, Council of the Institute of Molecular Biology and Biophysics, Swiss Federal Institute of Technology Zurich (reelected 2005), 2004

Additional qualifications

  • Didactics and management training: Leading Competence Training for Scientists, EMBL Grenoble, Switzerland, 2009

  • Swiss Federal Institute of Technology (ETH) Zurich Faculty Development Program in Didactics, Master level, 2006 – 2007

  • Conflict management seminar for scientists, organised by the Young Academy, Berlin, Germany, 2006

  • Young Leaders in Science Programme, organised by the Schering Foundation, Berlin, 2006

  • Management competence training for scientists, organised by the Young Academy, Berlin, 2005

  • ETH course in didactics (I + II), pedagogy, didactics for chemistry (I + II) (courses towards advanced teaching certification), 2002 – 2003


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