Short CV/Education and training

  • Since receiving my Diplom degree and completing my dissertation at the University of Konstanz (Germany), I have worked on intracellular calcium signals / membrane transport proteins / membrane biophysics (SERCA).

  • Afterward, during an almost three-year period as a visiting researcher in the USA, I was able to use imaging techniques, electrophysiology and molecular biology to identify the molecular components of a central calcium signal pathway (CRACM = ORAI ion channel) in immune system cells.

  • Currently, I and my Emmy Noether junior research group are working on characterising these proteins in various immune functions (human T-cells) and in primary prostate cells.

Selected publications

  • Holzmann, C., Kilch, T., Kappel, S., Armbruster, A., Jung, V., Stockle, M., Bogeski, I., Schwarz, E.C., and Peinelt, C. (2013) ICRAC controls the rapid androgen response in human primary prostate epithelial cells and is altered in prostate cancer. Oncotarget. 4, 2096-2107.

  • Kilch, T., Alansary, D., Peglow, M., Dorr, K., Rychkov, G., Rieger, H., Peinelt, C., and Niemeyer, B.A. (2013) Mutations of the Ca2+-sensing Stromal Interaction Molecule STIM1 Regulate Ca2+ Influx by Altered Oligomerization of STIM1 and by Destabilization of the Ca2+ Channel Orai1. J.Biol.Chem. 288, 1653-1664.

  • Stanisz, H., Stark, A., Kilch, T., Schwarz, E.C., Muller, C.S., Peinelt, C., Hoth, M., Niemeyer, B.A., Vogt, T., and Bogeski, I. (2012) ORAI1 Ca(2+) channels control endothelin-1-induced mitogenesis and melanogenesis in primary human melanocytes. J.Invest.Dermatol. 132, 1443-1451.

  • Bogeski, I., Kummerow, C., Al-Ansary, D., Schwarz, E.C., Koehler, R., Kozai, D., Takahashi, N., Peinelt, C., Griesemer, D., Bozem, M., Mori, Y., Hoth, M., and Niemeyer, B.A. (2010) Differential redox regulation of ORAI ion channels: a mechanism to tune cellular calcium signaling. Sci.Signal. 3, ra24

  • Bogeski, I., Al-Ansary, D., Qu, B., Niemeyer, B.A., Hoth, M., and Peinelt, C. (2010) Pharmacology of ORAI channels as a tool to understand their physiological functions. Expert Rev.Clin.Pharmacol. 3, 291-303.

  • Peinelt, C., Beck, A., Monteilh-Zoller, M.K., Penner, R., and Fleig, A. (2009) IP(3) receptor subtype-dependent activation of store-operated calcium entry through I(CRAC). Cell Calcium. 45, 326-330.

  • Parvez, S., Beck, A., Peinelt, C., Soboloff, J., Lis, A., Monteilh-Zoller, M., Gill, D.L., Fleig, A., and Penner, R. (2008) STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation. FASEB J. 22, 752-761.

  • Lis, A., Peinelt, C., Beck, A., Parvez, S., Monteilh-Zoller, M., Fleig, A., and Penner, R. (2007) CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties. Curr.Biol. 17, 794-800.

  • Vig, M., Peinelt, C., Beck, A., Koomoa, D.L., Rabah, D., Koblan-Huberson, M., Kraft, S., Turner, H., Fleig, A., Penner, R., and Kinet, J.P. (2006) CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science. 312, 1220-1223.

  • Peinelt, C., Lis, A., Beck, A., Fleig, A., and Penner, R. (2008) 2-Aminoethoxydiphenyl borate directly facilitates and indirectly inhibits STIM1-dependent gating of CRAC channels. J.Physiol. 586, 3061-3073.

  • Peinelt, C., Vig, M., Koomoa, D.L., Beck, A., Nadler, M.J., Koblan-Huberson, M., Lis, A., Fleig, A., Penner, R., and Kinet, J.P. (2006) Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nat.Cell Biol. 8, 771-773.

  • M. Vig, C. Peinelt, A. Beck, et al., CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry, Science. 312 (2006) 1220-1223.

Complete list of publications

Membership in scientific bodies/juries

  • Member of the Biophysical Society

  • Member of the German Association of University Professors and Lecturers

Additional qualifications

  • Funding from the DFG Emmy Noether Programme, 2009

  • Assistant professorship, 2008

Soft Skills/Other activities and achievements

Additional interests

  • Tabletop football

Other activities and achievements/family

  • 2 children


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