Short CV/Education and training

Education:

  • 1997
    Maîtrise (= Bachelor) of Biology and Medical Sciences, University of Pharmacy Paris V, France

  • 1998
    Completion of Pharmaceutical studies, University of Pharmacy Paris V, France

  • 1999
    Diplôme d'Etudes Approfondies (DEA = Master) "Oxidative Stress & Associated Diseases", University of Medicine Paris V, France

  • 2003
    Ph.D. diploma (Ph.D. Defense in January 2003) in Biology and Medical Sciences, University of Rennes 1, France, awarded with the highest score

Positions:

  • 1998 – 1998
    Pharmacy student, Department of Molecular & Cellular Biology, Jouveinal-Parke Davis Institute, Fresnes, France

  • 1999 – 1999
    DEA (= Master) student, Department of Molecular & Cellular Biology, Jouveinal-Parke Davis Institute, Fresnes, France

  • 1999 – 2000
    Senior associate scientist, Department of Molecular & Cellular Biology, Jouveinal-Parke Davis Institute, Fresnes, France

  • 2000 – 2003
    Ph.D. student, Prof. Vincent Lagente's laboratory, INSERM U456, University of Rennes I, France, in collaboration with Dr. Claude Bertrand, Director of Department of Biology, Pfizer Global R & D (previously Jouveinal-Parke Davis), Fresnes, France

  • 2003 – 2004
    Postdoc, Prof. Nigel Bunnett's laboratory, Department of Surgery, University of California, San Francisco, USA

  • 2004 – 2011
    Postdoc, Prof. Ueli Suter's laboratory, Institute of Cell Biology, ETH Zurich, Switzerland

  • 2011 – 2012
    Senior researcher, Prof. Ueli Suter's laboratory, Institute of Cell Biology, ETH Zurich, Switzerland

  • Since 2012
    SNSF Professor, Department of Biology, University of Fribourg, Switzerland

Selected publications

Articles:

  • *Corresponding author

  • Claire Jacob*, Pirmin Lötscher, Stefanie Engler, Arianna Baggiolini, Sandra Varum Tavares, Valérie Brügger, Nessy John, Stine Büchmann-Møller, Paige L. Snider, Simon J. Conway, Teppei Yamaguchi, Patrick Matthias, Lukas Sommer, Ned Mantei and Ueli Suter* (2014) HDAC1 and HDAC2 control the specification of neural crest cells into peripheral glia. The Journal of Neuroscience 34:6112-6122.

  • Pattaroni C, Jacob C* (2013) Histone methylation in the nervous system: functions and dysfunctions. Molecular Neurobiology 47:740-756.

  • Jacob C*, Lebrun-Julien F, Suter U* (2011) How histone deacetylases control myelination. Molecular Neurobiology 44:303-312 (invited review).

  • Jacob C*, Christen CN, Pereira J, Somandin C, Baggiolini A, Lötscher P, Özçelik M, Tricaud N, Meijer D, Yamaguchi T, Matthias P, Suter U* (2011) Schwann cell survival and myelination are critically dependent on HDAC1 and HDAC2 function. Nature Neuroscience 14:429-436. Featured in: Miller R (2011) Unwrapping HDAC1 and HDAC2 functions in Schwann cell myelination. Nature Neuroscience 14:401-403.

  • Cotter L, Özçelik M, Jacob C, Pereira JA, Locher V, Baumann R, Relvas JB, Suter U, Tricaud N (2010) Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Science 328:1415-1418.

  • Pereira JA, Baumann R, Norrmén C, Somandin C, Miehe M, Jacob C, Lühmann T, Hall-Bozic H, Mantei N, Meijer D, Suter U (2010) Dicer in Schwann cells is required for myelination and axonal integrity. The Journal of Neuroscience 30:6763-6775.

  • Ozcelik M, Cotter L, Jacob C, Pereira J, Relvas J, Suter U, Tricaud N (2010) Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves. The Journal of Neuroscience 30:4120-4131.

  • Jacob C*, Grabner H, Atanasoski S, Suter U (2008) Expression and localization of Ski determine cell type-specific effects of TGFbeta on the cell cycle. Journal of Cell Biology 182:519-530.



Complete list of publications

Selected projects

Patent:

  • Inventors: Jacob Claire and Szilagyi Corinne

    Non-recombinant cell lines capable of expressing a single PDE4 subtype and their use for the screening of PDE4 subtype-specific modulators

    Patent n° 01401026.8-1212, registered in Europe.

Membership in scientific bodies/juries

  • Director, Co-Referee, and Jury President of several PhD theses

  • Reviewer for David Phillips Fellowship grant for the BBSRC (UK)

  • Reviewer for diverse scientific journals

Media coverage

Additional qualifications

  • PostdDoc, 2004, Chronic inflammatory mechanisms


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