Prof. Dr. Doris Wedlich
- German Research Foundation (DFG)
- AcademiaNet member since 17.05.2010
- AcademiaNet- Selection Criteria
- Karlsruher Institut für Technologie (KIT)
- Natural sciences, mathematics and statistics
Biological and related sciences
Area of specialisation
Cell and developmental biology
During my PhD and postdoc time I was fascinated by the accuracy of morphogenetic processes in early embryonic development.
My interests in molecular biology emerged with upcoming new techniques (e.g. production of monoclonal antibodies, differential expression profiling, gene knockout/knockdown and genetic screens by mutagenesis) that enabled embryologists to identify the genes expressed in the Spemann Organizer.
With the growing knowledge about the genes involved in patterning the body axis, their evolutionary conservation and their contribution to human diseases I decided to use the Xenopus embryo as a model to investigate the role of cell adhesion and Wnt-signalling in morphogenetic processes.
At the University of Ulm I shared my embryonic experience about the double role of ß-catenin in canonical Wnt-signalling and cadherin-mediated adhesion with the pancreas cancer department. Funded by the DFG (German Research Foundation) and the Deutsche Krebshilfe (German Cancer Aid) we identified new links between cell adhesion and signalling pathways. With the advancement in microscopy and the detection of fluorescent proteins I started to combine cellular and developmental biology. Thereby, we unravelled the function of cadherins and the non-canonical Wnt-signalling network in gastrulation movement and neural crest migration. Driven by the uniqueness of the KIT I have started an interdisciplinary research project with chemists, physicists and engineers in nano-biology funded by the DFG.
At present, I see the challenge but also the break-through in the combination of smart technologies of material and engineering sciences with basic principles in cellular and developmental biology.
Distinctions and Awards
Appointed to the German Council of Science and Humanities, 2012
Hector Fellowship, 2009
Research Award from the State of Baden-Württemberg, 2002
Merckle Research Prize, 1994
- Management position, Membership in scientific bodies, Refereeing
1981: Cytologische Untersuchungen zum Funktions- und Formenwechsel meiotischer Chromosomen von der Differenzierung des Ei-Nährverbands bis zur Karyogamie bei der Diptere Calliphora erythrocephala ("Cytological investigations of the changes in function and form of meiotic chromosomes from the differentiation of the nurse cells to karyogamy in the Diptera Calliphora erythrocephala")
PostDoc qualification, e.g. Habilitation
1986: Die Bedeutung der Zelladhäsion in der Somitenbildung von Xenopus laevis ("The significance of cell adhesion in somite formation by Xenopus laevis")