Short CV/Education and training

  • 1985 – 1990
    Undergraduate and predoctoral training, Faculty of Medicine, Utrecht University, Netherlands

  • 1990 – 1994
    PhD student at the Research Laboratory of Neurology, Rudolf Magnus Institute for Neurosciences, Faculty of Medicine, Utrecht University

  • 1995 – 1996
    Two year Max-Planck fellowship. Post-doctoral fellow at the department of Neuromorphology, Max-Planck-Institute for Neurobiology, Planegg-Martinsried, Germany

  • 1996 – 1999
    Post-doctoral fellow at the Netherlands Inst. for Brain Research

  • 1999
    Staff member of the Netherlands Institute for Brain Research, Amsterdam

  • 2003 – 2013
    Group leader research group Astrocyte biology & neurodegeneration, Netherlands Institute for Neuroscience, Amsterdam

  • 2011
    Appointed as professor of Biology of Glia and Neural Stem Cells, at the Swammerdam Institute for life Sciences, Center for Neuroscience, University of Amsterdam

  • Since 2013
    Guest researcher, Netherlands Institute for Neuroscience, Amsterdam

  • Since 2013
    Associated professor, Brain Center Rudolf Magnus, University Medical Center Utrecht.

Selected publications

  • Kamphuis, W., Middeldorp, J., Kooijman, L., Sluijs, J.A., Kooi,E.J., Moeton, M., Freriks, M., Mizee, M.R., and Hol, E.M. Glial Fibrillary Acidic Protein (GFAP) isoform expression in plaque related astrogliosis in Alzheimer Disease. Neurobiology of Aging (Accepted – 23 Sept 2013).

  • Mamber, C. Kozareva, D.A., Kamphuis, W. and Hol, E.M. Shades of Grey: The Delineation of Marker Expression within the Adult Rodent Subventricular Zone. Prog Neurobiology (accepted 1 august 2013).

  • Kanski, R., Van Strien, M.E., Van Tijn, P., and Hol, E.M. A star is born: New insights into the mechanism of astrogenesis. Cellular and Molecular Life Sciences (Epub 2 August 2013).

  • Kamphuis, W., Orre, A.M., Kooijman, L., Dahmen, M., and Hol, E.M. Differential cell proliferation in the cortex of the APPswePS1dE9 Alzheimer's disease mouse model. Glia 60 (2012) 615-629.

  • Vedam Mai, V., van Battum, E.Y., Kamphuis, W., Feenstra, M.G.P., Denys, D. Reynolds, B.A., Okun M.S. and Hol, E.M. Deep brain stimulation and the role of astrocytes. Molecular Psychiatry 17 (2012) 124-131

  • Van den Berge, S.A., van Strien, M.E., Korecka, J., Dijkstra, A.A., Sluijs, J.A., Kooijman L., Eggers, R., De Filippis, L., Vescovi, A.L., Verhaagen, J. van de Berg, W.D.J. and Hol, E.M. The proliferative capacity of subventricular neural stem cells is maintained in the Parkinsonian brain. Brain 134 (2011) 3249-3263.

  • Middeldorp, J. and Hol, E.M. GFAP in health and disease. Progress in Neurobiology 93 (2011) 421-443.

  • Mamber, C., Verhaagen, J. and Hol, E.M. In Vivo Targeting of Subventricular Zone Astrocytes. Progress in Neurobiology 92 (2010) 19-32.

  • Van den Berge, S.A., Middeldorp, J., Zhang, C.E., Curtis, M.A. Leonard, B.W., Mastroeni, D. van de Berg, W.D.J., Huitinga, I., and Hol, E.M. Longterm quiescent cells in the aged human subventricular neurogenic system specifically express GFAP-?. Aging Cell 9 (2010) 313-326.

  • Riemersma-van der Lek, R.F., Swaab, D.F., Twisk, J., Hol, E.M., Hoogendijk, W.J.G.H and van Someren, E.J.W. Prevention of cognitive and non-cognitive symptoms in elderly residents of group care facilities: a randomized controlled trial on long-term bright-light and melatonin. JAMA 299 (22) (2008) 2642-2655.

  • Korecka, J.A., Verhaagen, J. and Hol, E.M. Cellular replacement strategies for Parkinson?s and Alzheimer?s disease. Regenerative Medicine, 2 (2007) 425-446.

  • Van Tijn, P, De Vrij, F.M.S., Schuurman, K.G., Dantuma, N.P., Fischer, D.F., Van Leeuwen, F.W. and Hol, E.M. Disturbance of proteasome activity by mutant ubiquitin. J Cell Sci. 120 (2007) 1615-1623.

  • Hol, E.M., Fischer, D.F., Ovaa, H. and Scheper, W. The ubiquitin proteasome system as a pharmacological target in neurodegeneration. Expert review of Neurotherapeutics 6 (2006) 1337-1347.



Complete list of publications

Selected projects

  • Creating adult neural stem cell lines derived from the neurogenic subventricular zone of Parkinson patients and controls: towards an in vitro model for neurogenesis in Parkinson.

  • COST – Nanomechanics of Nanomechanics of intermediate filament networks – NANONET BM1002

  • Mechanosensing and mechanotransduction by cells

  • Grasping adult neurogenic astrocytes: towards their recruitment for brain repair

  • Reactive astrocytes and proteasomal activity in Alzheimer

Membership in scientific bodies/juries

  • Dutch Society for Stem Cell Research (DSSCR)

  • Society for neuroscience (USA)

  • Federation of European Neuroscience Societies

  • EKN: Dutch Society for Experimental and Clinical Neurosciences

  • PHEPH: Society for Medical Biologists Utrecht University, NL.

Committees:

  • Member of the Scientific Advisory Board of the Dutch Brain Foundation (Hersenstichting Nederland, since 1 June 2012

  • President of the European Society for Intermediate Filament Biology, since 2011

  • Council member of European Society for Intermediate, Filament Biology, since 2010

  • Board [secretariat] "Vrienden van de Neurofederatie", since 2009

  • Member of NWO-ALW-TOP committee 2009

  • Beroepenveldcommissie, bachelorsopleiding Life Sciences, Hoge School Utrecht, since 2009

  • Chair of committee that organized the annual PhD-student meeting of the graduate school Neurosciences Amsterdam-Rotterdam, 2003 – 2011

  • Member of ONWAR Swammerdam Lecture Committee, since 2007

  • Member of ONWAR teaching committee, since 2003

  • Member Board of Supervision: (Lid van het college van toezicht van de bachelorsopleiding Life Sciences, Hoge School Utrecht), 2006 – 2009

  • Member of the evaluation panel member for Neuroscience and Endocrine Systems of the Portuguese Science and Technology Foundation in February and November 2002

  • Member of review committee of the "NWO-ALW" open competition, since 2003

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