Short CV/Education and training

  • 1982
    A-levels at the French International School in Washington D.C., USA

  • 1984
    Postdoctoral program for recognition of degree from the Engineering School at the Lycée Sainte-Geneviève in Versailles, France

  • 1987
    Diplom degree at the Ecole Centrale in Paris, France

  • 1987
    Post-Graduate Degree at the Ecole Centrale in Paris, France

  • 1990
    PhD at the University of Paris VI, France

  • 1987 – 1990
    Research assistant in the Faculty for Cellular Biology, CEA (French Alternative Energies and Atomic Energy Commission), in Gif-sur-Yvette, France

  • 1990 – 1993
    Postdoc at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany

  • 1994 – 2001
    Group leader of the Faculty for Biochemistry at the University of Geneva, Switzerland

  • 2001 – 2006
    Adjunct professor in the Faculty for Microbiology and Molecular Medicine, Medical School, at the University of Geneva, Switzerland

  • Since 2006
    Professor at the Global Health Institute, School of Life Sciences, at the Ecole Polytechnique Fédérale de Lausanne, Switzerland

Selected publications

  • Van der Goot, F.G. et al.: A "molten globule" membrane insertion intermediate of the pore forming domain of colicin A. In: Nature, 354, 1991. S. 408-410.

  • Abrami, L. et al.: A pore-forming toxin binds to GPI-anchored proteins and causes vacuolation of the endoplasmic reticulum. In: Journal of Cell Biology 140, 1998. S. 525-540.

  • Fivaz, M. et al.: Differential sorting and fate of endocytosed gpi-anchored proteins. In: EMBO J. 21, 2002. S. 3989-4000.

  • Tsitrin, Y. et al.: Convertion of a transmembrane to a water soluble protein complex by a single point mutation. In: Nature Structural Biology 9, 2002. S. 729-733.

  • Abrami, L. et al.: Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway. In: Journal of Cell Biology 166, 2004. S. 645–651.

  • Abrami, L. et al.: Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis. In: Journal of Cell Biology 172, 2006. S. 309-320.

  • Iacovache, I. et al.: A rivet model for channel formation by aerolysin-like pore-forming toxins. In: EMBO J. 25, 2006. S. 457-466.

  • Gurcel, L. et al.: Caspase-1 dependent activation of SREBP promotes cell survival in response to bacterial pore-forming toxins. In: Cell 126, 2006. S. 1135-1145.

  • Abrami, L. et al.: Palmitoylation and ubiquitination regulate exit of the Wnt signaling protein LRP6 from the endoplasmic reticulum. In: Proc Natl Acad Sci USA 105(14), 2008. S. 5384-5389.

  • Deuquet, J. et al.: Systemic hyalinosis mutations in the CMG2 ectodomain leading to loss of function through retention in the endoplasmic reticulum. In: Human Mutations 30, 2009. S. 583-589.

  • Abrami, L. et al.: Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors. In: PLoS Pathogen 6(3), 2010. e1000792.


Membership in scientific bodies/juries

  • Member of the European Research Council (ERC)

  • Vice president of the Swiss Union of Experimental Science (USGEB)

  • Editor, HFSP Journal

  • Member of the scientific advisory board of the Bettencourt-Schueller Foundation in Paris, France

  • Member of the scientific advisory board of the Novartis Consumer Health Foundation

  • Member of the scientific advisory board of the Centre Intégratif de Génomique in Lausanne, Switzerland

  • Member of the Swiss Society for Biochemistry and the Swiss Society for Cellular Biology

  • Member of the American Society of Cell Biology

  • Member of the American Society of Microbiology

  • Elected European Molecular Biology Organisation (EMBO) member, 2009

  • Member of the National Research Council of the Swiss National Fund for promoting scientific research, 2002 to present

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