Short CV/Education and training

  • 1984
    High school diploma and Abitur (A-levels), John F. Kennedy School, Berlin, Germany

  • 1985 – 1987
    B.A., Wellesley College, Wellesley, MA, USA

  • 1987 – 1992
    M.A., Harvard University, Cambridge, MA, USA

  • 1992
    PhD, Harvard University, Cambridge, MA

  • 1997
    Habilitation (postdoctoral qualification) in the field of molecular biology/molecular medicine at the University of Freiburg, Germany

  • 1998
    Heisenberg Fellowship from the German Research Foundation (DFG)

  • 1998 – 2012
    C3 professor of experimental anaesthesiology at the University of Freiburg Faculty of Medicine

  • since 2012
    C3 professor of molecular haematology at the University of Freiburg Faculty of Medicine

Selected publications

  • Jutzi JS, Bogeska R, Nikoloski G, Schmid CA, Seeger TS, Stegelmann F, Schwemmers S, Gründer A, Peeken J, Gothwal M, Wehrle J, Aumann K, Hamdi K, Dierks, C, Wang W, Döhner K, Jansen JH, Pahl HL (2013) MPN patients harbor recurrent truncating mutations in transcription factor NF-E2, J. Ex. Med, in press.

  • Wehrle J, Seeger TS, Schwemmers S, Pfeifer D, Bulashevska A , Pahl HL (2013) Transcription factor NF-E2 mediates expression of the cytoine IL8, a known predictor of inferior outcome in MPN patients. Haematologica, in press.

  • Kaufmann KB, Gründer A, Hadlich T, Wehrle J, Gothwal M, Bogeska R, Seeger TS, Kayer S, Pham KB, Jutzi JS, Ganzenmüller L, Steinemann D, Schlegelberger B, Wagner JM, Jung M, Will B, Steidl U, Aumann K, Werner M, Günther T, Schüle R, Rambaldi A, Pahl HL, (2012) A novel murine model of myeloproliferative disorders generated by overexpressionof the transcription factor NF-E2. J. Exp. Med, 209: 35 – 50.

  • Wang, W. et al.: AML1 is overexpressed in patients with myeloproliferative neoplasms and mediates JAK2V617F-independent overexpression of NF-E2. In: Blood 116, 2010 S. 254-266.

  • Jones AV, Chase A, Silver RT, Oscier D, Zoi K, Wang YL, Cario H, Pahl HL, Reiter A, Grand F, Cross NCP (2009) JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms, Nature Genetics, 41: 446 ? 449.

  • Mutschler M, Magin AS, Buerge M, Roelz R, Schanne DH, Will B, Pilz I, Migliaccio AR, Pahl HL (2009) NF-E2 Overexpression Delays Erythroid Maturation and Increases Erythrocyte Production, British J. Haematol., 146: 203 – 217.

  • Goerttler, P.S. et al.: Gene Expression Profiling in Polycythemia vera: Overexpression of transcription factor NF-E2. In: Br. J. Haematol 129, 2005. S. 138-150.

  • Klippel, S. et al.: Quantification of PRV-1 mRNA distinguishes Polycythemia vera from Secondary Erythrocytosis. In: Blood 102, 2003. S. 3569-3574.

  • Klippel S, Strunck E , Busse CE, Behringer D, Pahl HL (2002) Biochemical Characterization of PRV-1, a Novel Hematopoietic Cell Surface Receptor, which is Overexpressed in Polycythemia rubra vera., Blood, 100: 2441-2448.

  • Temerinac, S. et al.: Cloning of PRV-1, a Novel Member of the uPAR Receptor Superfamily, which is Overexpressed in Polycythemia rubra vera. In: Blood 95, 2000. S. 2569-2576.

Selected projects

  • Molecular markers of myeloproliferative diseases

  • Mouse models of myeloproliferative diseases

Membership in scientific bodies/juries

  • Member of the editorial board for the journal Blood

  • Section editor for experimental haematology for the journal Annals of Haematology

  • Member of the editorial board for the journal Current Signal Transduction Therapy

  • Member of the editorial board for the journal The European Journal of Clinical & Medical Oncology

  • Member of the Baden-Württemberg State Council for Education, 2001 – 2007

  • Member of the scientific board of the Else Kröner Fresenius Foundation

Soft Skills/Other activities and achievements

Soft Skills

  • Mother of three sons, born 2001, 2003 and 2005


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