Short CV/Education and training

  • 1976
    Born in Cambridge, UK

  • 1994 – 1998
    Bsc in Biochemistry at the University of Bath, UK

  • 1998 – 2001
    PhD in Structural biology at the University of St Andrews, UK

  • 2001 – 2005
    Postdoctoral studies at St Jude's Children's Research Hospital, Memphis USA

  • Since 2005
    Group Leader at Cancer Research UK London Research Institute

  • Since 2013
    Group Leader at MRC Phosphorylation and Ubiquitylation Unit, University of Dundee

Selected publications

  • A. Kumar, V.K. Chaugule, T.E.C. Condos, K.R. Barber, C. Johnson, R. Toth, R. Sundaramoorthy, A. Knebel, G.S. Shaw & H. Walden. Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity. Nature Structural and Molecular Biology (2017) DOI: 10.1038/nsmb.3400

  • A. Kumar*, J.D. Aguirre*, T.E.C. Condos*, R.J. Martinez-Torres*, V.K. Chaugule, R. Toth, R. Sundaramoorthy, P. Mercier, A. Knebel, D.E. Spratt, K.R. Barber, G.S. Shaw*, & H. Walden*. Disruption of the autoinhibited state primes the E3 ligase Parkin for activation and catalysis. EMBO Journal (2015) 34 p.2506-21 DOI:10.15252/embj.201592337

  • J.A. Miles, M.G. Frost, E. Carroll, M.L. Rowe, M.J. Howard, A. Sidhu, V.K. Chaugule, A.F. Alpi*, & H. Walden*. The Fanconi Anemia DNA repair pathway is regulated by an interaction between ubiquitin and the E2-like fold domain of FANCL. Journal of Biological Chemistry (2015) 10.1074/jbc.M115.675835

  • C. Hodson, A. Purkiss, J.A. Miles & H.Walden. Structure of human FANCL RING-Ube2T complex reveals determinants of cognate E2-E3 selection. (2014) Structure, 22, 337-344

  • D.E. Spratt*, R.J. Martinez-Torres*, Y.J. Noh*, P. Mercier, N. Manczyk, K.R. Barber, J.D. Aguirre, L. Burchell, A. Purkiss, H.Walden*, & G.S.Shaw*. A molecular explanation for the recessive nature of parkin-linked Parkinson's disease Nature Communications (2013) 10.1038/ncomms2983

  • Chaugule VK, Burchell L, Barber KR, Sidhu A, Leslie SJ, Shaw GS, Walden H. Autoregulation of Parkin through its ubiquitin-like domain. EMBO J. 2011; 30 2853-2867

  • Hodson C, Cole AR, Lewis LP, Miles JA, Purkiss A, Walden H. Structural Analysis of Human FANCL, the E3 Ligase in the Fanconi Anemia Pathway. J Biol Chem. 2011;286(37):32628-37

  • Cole AR, Lewis LP, Walden H. The structure of FANCL, the catalytic subunit of the Fanconi Anemia core complex. Nat Struct Mol Biol. 2010;17(3):294-8

  • Ulrich HD, Walden H. Ubiquitin signalling in DNA replication and repair. Nat Rev Mol Cell Biol. 2010;11(7):479-89

  • Zhuang M, Calabrese MF, Liu J, Waddell MB, Nourse A, Hammel M, Miller DJ, Walden H, Duda DM, Seyedin SN, Hoggard T, Harper JW, White KP, Schulman BA. Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases. Molecular Cell. 2009;36:39-50

  • Turner SJ, Kedzierska K, Komodromou H, La Gruta NL, Dunstone MA, Webb AI, Webby R, Walden H, Xie W, McCluskey J, Purcell AW, Rossjohn J, Doherty PC. Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations. Nature Immunol. 2005;6:382-389

  • Walden H, Podgorski MS, Huang DT, Miller DW, Howard RJ, Minor DL Jr, Holton JM, Schulman BA. The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1. Mol Cell. 2003;12:1427-1437

  • Walden H, Podgorski MS, Schulman BA. Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. Nature. 2003;422(6929):330-4

Soft Skills/Other activities and achievements

Other activities and achievements/family

  • one son (2008) and one daughter (2010)


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