Short CV/Education and training

  • Since 2010
    Managing director of the Centre for Molecular Medicine, Goethe University Frankfurt

  • Since 2008
    ECCPS chair (W3) of vascular signalling at Goethe University Frankfurt

  • 2007 – 2008
    Managing director of the Centre for Physiology, Goethe University Frankfurt

  • 2007
    Offer of a C4 professorship (Foundation Chair of Biomedical Sciences) at the University of Hull Medical School, England

  • 2005
    Spokesperson of FG 501 "Vascular homeostasis: molecular mediators and cellular mechanisms"

  • Since 2004
    University professor (C3) of physiology at Goethe University Frankfurt

  • 2003
    Offer of a C4 professorship in molecular medicine at the Technical University of Munich, Germany (declined)

  • 2001
    Appointment as university lecturer (C2)

  • 1999
    Habilitation (postdoctoral qualification) in physiology

  • 1993 – 1999
    Research associate at the Institute of Cardiovascular Physiology, Goethe University Frankfurt, Germany

  • 1991 – 1993
    Postdoc at the Institute of Applied Physiology, University of Freiburg, Germany

  • 1988 – 1991
    Doctoral work at the University of Strasbourg, France. Mark: très honorable

  • 1986 – 1987
    Trainee programme (Gastrointestinal Diseases Project), Beecham Pharmaceuticals Research Division, Harlow, England

  • 1984 – 1988
    Studied pharmacology and biochemistry at Aston University, Birmingham, England. Degree: Bachelor of Science, Combined Honours (First Class)

  • 1977 – 1984
    Cambridge House Girls' Grammar School, Ballymena, Northern Ireland

Selected publications

  • Randriamboavonjy, V. et al.: AMPK {alpha}2 subunit is involved in platelet signaling, clot retraction, and thrombus stability. In: Blood 116, 2010. pp. 2134-2140.

  • Loot, A.E. et al.: Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase. In: J Exp Med 206, 2009. pp. 2889-2896.

  • Randriamboavonjy, V. et al.: Platelet SERCA-2 and µ-calpain activity are altered in type 2 diabetes and restored by rosiglitazone. In: Circulation 117, 2008. pp. 52-60.

  • Fisslthaler, B. et al.: Inhibition of endothelial nitric oxide synthase activity by proline-rich tyrosine kinase 2 in response to fluid shear stress and insulin. In: Circ Res. 102, 2008. pp. 1520-1528.

  • Fisslthaler, B. et al.: Fluid shear stress and NO decrease the activity of the hydroxy-methylglutaryl coenzyme A reductase in endothelial cells via the AMP-activated protein kinase and FoxO1. In: Circ. Res. 100, 2007. e12-e21.

  • Fleming, I. et al.: Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells. In: Arterioscler Thromb Vasc Biol. 27, 2007. pp. 2612-2618.

  • Jung, O. et al.: Soluble epoxide hydrolase is a main effector of angiotensin II-induced hypertension. In: Hypertension 45, 2005. pp. 759-765.

  • Fleming, I. et al.: Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells. In: J Cell Sci. 118, 2005. pp. 4103-4111. Highlighted in the editor's choice Sci. Signal. 302, 2005. tw333.

  • Dixit, M. et al.: Gab1, SHP2, and protein kinase A are crucial for the activation of the endothelial NO synthase by fluid shear stress. In: Circ Res. 97, 2005. pp. 1236-1244.

  • Fichtlscherer, S. et al.: Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease. In: Circulation 109, 2004. pp. 178-183.


Selected projects

  • ECCPS Cardio-Pulmonary System

  • SFB 834 "Endothelial Signalling and Vascular Repair"

  • SFB 815 "Redox Regulation: Generator systems and functional consequences"

  • SFB/Transregio 23 "Vascular differentiation and remodelling"

  • European Graduate School GRK 757 "Roles of Eicosanoids in Biology and Medicine"

  • LOEWE Lipid Signalling Research Centre of Frankfurt, Germany (LIFF)

Membership in scientific bodies/juries

  • German National Academy of Sciences Leopoldina, since 2016

  • German Physiological Society (DPG)

  • German Cardiac Society

  • German Society for Microcirculation and Vascular Biology

  • British Pharmacological Society

  • North American Vascular Biology Organisation

  • American Society for Biochemistry and Molecular Biology

  • American Heart Association

Board member:

  • American Journal of Physiology

  • Basic Research in Cardiology

  • British Journal of Pharmacology

  • Journal of Cardiovascular Pharmacology

  • Cons. Editor / Associate Editor:

  • Journal of Vascular Research

  • Cardiovascular Research

  • Circulation Research

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