Short CV/Education and training

  • 1985 – 1987
    Doctoral studies at Saarland University, Saarbrücken, and Lund University, Sweden

  • 1988 – 1990
    Post-doc at the Research Institute of Molecular Pathology (IMP) in Vienna, Austria

  • 1991 – 1995
    Post-doc at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany

  • Since 1996
    Independent leader of the research group Mammalian Cell Cycle Control Mechanisms at the German Cancer Research Center (DKFZ) in Heidelberg

Selected publications

  • Hoffmann, I. and Birnstiel, M.L. (1990). The cell-cycle dependent regulation of histone precursor mRNA processing involves heat-labile factor modulation of U7 snRNA accessibility, Nature 346, 665-668

  • Hoffmann, I., Clarke, P, Marcote, M.J., Karsenti, E. and Draetta, G. (1993) Activation of Cdc25 by phosphorylation at mitosis and its involvement in the self-amplification of MPF. EMBO J. 12, 53-63.

  • Hoffmann, I., Draetta, G. and Karsenti, E. (1994) Activation of the phosphatase activity of human Cdc25A by a Cdk2-cyclin E dependent phosphorylation at the G1/S transition EMBO J. 13, 4302-4310.

  • Blomberg, I and Hoffmann, I. (1999) Ectopic expression of Cdc25A accelerates the G1/S transition and leads to activation of cyclin E and cyclin A-dependent kinases. Mol. Cell. Biol. 19, 6183-6194.

  • Warnke S., Kemmler S., Hames RS, Tsai HL, Hoffmann-Rohrer U., Fry AM, and Hoffmann I. (2004) The polo-like kinase-2 is required for centriole duplication in mammalian cells. Curr. Biol. 14, 1200-1207.

  • Cizmecioglu, O., Arnold, M., Bahtz, R., Settele, F., Ehret, L., Haselmann-Weiß, U., Antony, C. and Hoffmann, I. (2010). Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome. J. Cell Biol. 191, 731-739.

  • Puklowski, A., Homsi, Y., Chauhan, S., Keller, D., Grünwald, V., Kubicka, S., Pich, A., Mann, M., Hoffmann, I., Gönczy, P. and Malek, N. (2011) The activity of the SCFFbw5 E3-ubiquitin ligase is regulated by the APC/C and Plk4 to control centrosome duplication. Nat. Cell Biol. 13, 1004-9.

  • Bahtz, R., Seidler, J., Arnold, M., Haselmann-Weiss, U., Antony, C., Lehmann, W and Hoffmann, I., (2012) GCP6 is a substrate of Plk4 and required for centriole duplication, J. Cell Sci., 125, 1-11.


Selected projects

  • https://www.dkfz.de/en/f045/index.php

Membership in scientific bodies/juries

  • Business manager of the German Society for Cell Biology (DGZ), 2006 – 2008

  • Member of the advisory board the DGZ, since 2008

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