Short CV/Education and training

  • 1979 – 1983
    Studied food chemistry at LMU Munich, Germany

  • 1983
    1st state examination

  • 1984
    2nd state examination

  • 1985 – 1989
    Doctoral studies at the Max Planck Institute (MPI) of Biochemistry, Martinsried, and at the MPI of Biophysics, Frankfurt, Germany

  • 1989 – 1991
    Postdoc at the Max Planck Institute of Biophysics, Frankfurt

  • 1991 – 1993
    Researcher at the Biomedical Centre at Uppsala University, Sweden

  • 1994 – 1999
    Group Leader at the European Molecular Biology Laboratory (EMBL)

  • Since 2000
    Chair of structural biology at the Heidelberg University Biochemistry Centre (BZH), Germany

  • 2006 – 2009
    Director of the BZH

Selected publications

  • Kressler, D. et al. (2012) Synchronizing nuclear import of ribosomal proteins with ribosome assembly, Science 338: 666-71.

  • Holdermann, I. et al. (2012) Chromodomains read the arginine code of post-translational targeting, Nat. Struct. Mol. Biol. 19: 260-63.

  • Bange, G. et al. (2011) Structural basis for the molecular evolution of SRP-GTPase activation by protein, Nat. Struct. Mol. Biol. 18: 1376-80.

  • Stefer, S. et al. (2011) Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex, Science 333: 758-62.

  • Stengel, K. et al. (2008) Structural basis for specific substrate recognition by the chloroplast signal recognition particle protein cpSRP43, Science 321: 253-6.

  • Bange, G. et al. (2007) The crystal structure of the third SRP GTPase FlhF reveals a homodimer with bound GTP, Proc. Natl. Acad.Sci. USA 104: 13621-13625.

  • Rosendal, K.R. et al. (2003) Crystal structure of the complete core of archaeal signal recognition particle and implications for inter-domain communication, Proc. Natl. Acad. Sci. USA 100: 14701-14706.

  • de Leeuw, E. et al. (2000) Anionic phospholipids are involved in membrane association of the Signal Recognition Particle receptor FtsY and stimulate its GTPase activity, EMBO J. 19: 531-541.

  • Montoya, G. et al. (1997) Crystal structure of the NG-domain of the signal-recognition particle receptor FtsY, Nature 385: 365-368.

  • Deisenhofer, J. et al. (1995) Crystallographic refinement at 2.3 A resolution and refined model of the photosynthetic reaction centre from Rhodopseudomonas viridis, J. Mol. Biol. 246: 429-457.

Membership in scientific bodies/juries

  • Member of the German Research Foundation (DFG) panel Biochemistry/Biophysics, since 2008

  • President of the Society for Biochemistry and Molecular Biology (GBM), since 2010

  • Member of the senate commission of the Helmholtz Association, 2010


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  1. Cellular "Postman" Identified

    Heidelberg researchers have characterised the structure and function of an important element of the complex transport system within the cell: the signal recognition particle, or SRP, is the molecular "postman" for the sorting and membrane insertion of proteins.

  2. Leibniz Prizes for AcademiaNet Members

    The Leibniz Prize is the most important research award in Germany, with a sum total of 25 million Euros. Congratulations to Brigitte Röder, Nicole Dubilier, Artemis Alexiadou and Irmgard Sinning!