Short CV/Education and training

  • 1979 – 1983
    Studied food chemistry at LMU Munich, Germany

  • 1983
    1st state examination

  • 1984
    2nd state examination

  • 1985 – 1989
    Doctoral studies at the Max Planck Institute (MPI) of Biochemistry, Martinsried, and at the MPI of Biophysics, Frankfurt, Germany

  • 1989 – 1991
    Postdoc at the Max Planck Institute of Biophysics, Frankfurt

  • 1991 – 1993
    Researcher at the Biomedical Centre at Uppsala University, Sweden

  • 1994 – 1999
    Group Leader at the European Molecular Biology Laboratory (EMBL)

  • Since 2000
    Chair of structural biology at the Heidelberg University Biochemistry Centre (BZH), Germany

  • 2006 – 2009
    Director of the BZH

Selected publications

  • Kressler, D. et al. (2012) Synchronizing nuclear import of ribosomal proteins with ribosome assembly, Science 338: 666-71.

  • Holdermann, I. et al. (2012) Chromodomains read the arginine code of post-translational targeting, Nat. Struct. Mol. Biol. 19: 260-63.

  • Bange, G. et al. (2011) Structural basis for the molecular evolution of SRP-GTPase activation by protein, Nat. Struct. Mol. Biol. 18: 1376-80.

  • Stefer, S. et al. (2011) Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex, Science 333: 758-62.

  • Stengel, K. et al. (2008) Structural basis for specific substrate recognition by the chloroplast signal recognition particle protein cpSRP43, Science 321: 253-6.

  • Bange, G. et al. (2007) The crystal structure of the third SRP GTPase FlhF reveals a homodimer with bound GTP, Proc. Natl. Acad.Sci. USA 104: 13621-13625.

  • Rosendal, K.R. et al. (2003) Crystal structure of the complete core of archaeal signal recognition particle and implications for inter-domain communication, Proc. Natl. Acad. Sci. USA 100: 14701-14706.

  • de Leeuw, E. et al. (2000) Anionic phospholipids are involved in membrane association of the Signal Recognition Particle receptor FtsY and stimulate its GTPase activity, EMBO J. 19: 531-541.

  • Montoya, G. et al. (1997) Crystal structure of the NG-domain of the signal-recognition particle receptor FtsY, Nature 385: 365-368.

  • Deisenhofer, J. et al. (1995) Crystallographic refinement at 2.3 A resolution and refined model of the photosynthetic reaction centre from Rhodopseudomonas viridis, J. Mol. Biol. 246: 429-457.


Membership in scientific bodies/juries

  • Member of the German Research Foundation (DFG) panel Biochemistry/Biophysics, since 2008

  • President of the Society for Biochemistry and Molecular Biology (GBM), since 2010

  • Member of the senate commission of the Helmholtz Association, 2010

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News

  1. Cellular "Postman" Identified

    Heidelberg researchers have characterised the structure and function of an important element of the complex transport system within the cell: the signal recognition particle, or SRP, is the molecular "postman" for the sorting and membrane insertion of proteins.

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    The Leibniz Prize is the most important research award in Germany, with a sum total of 25 million Euros. Congratulations to Brigitte Röder, Nicole Dubilier, Artemis Alexiadou and Irmgard Sinning!