Short CV/Education and training

  • 1965
    Born (December)

  • 1989
    Masters in Molecular Biology, University Louis Pasteur, Strasbourg, France

  • 1994
    Ph.D. in Developmental Neurobiology (European degree), University Louis Pasteur, Strasbourg, France/Friedrich Miescher Institute, Basel, Switzerland

  • 1994 – 1998
    Postdoctoral Fellow at the Center for Neurobiology and Behavior, Howard Hughes Medical Institute, Columbia University, New York, USA

  • 1998
    Assistant Professor in Neurobiology, Department of Biology, Swiss Federal Institute of Technology Zürich, Switzerland

  • 2002
    Visiting Professor, Stanford University School of Medicine, Palo Alto, USA

  • 2004
    Professor in Molecular and Cognitive Neurosciences, Brain Research Institute, Medical Faculty of the University Zürich and Department of Biology of the Swiss Federal Institute of Technology Zürich Switzerland

  • 2005
    Visiting Professor, Massachusetts Institute of Technology, Boston, USA

  • 2007
    Managing Director, Brain Research Institute, University Zürich Neuroscience Representative, Department of Biology, Swiss Federal Institute of Technology Zürich. 4-year term.

  • 2009
    Visiting Professor, Scripps Research Institute, La Jolla, USA

Selected publications

  • Bohacek, J. and Mansuy I.M. (2017). A guide to designing germline-dependent epigenetic inheritance experiments in mammals. Nature Methods 14:243-49.

  • Razoux, F., Russig, R., Baltes, C. Mueggler, T., Dikaiou, K., Rudin, M. and Mansuy I.M. (2017). Transgenerational disruption of functional 5-HT1AR-induced connectivity in the adult mouse brain by traumatic stress in early life. Mol. Psych. 22:519-26.

  • Gapp K, Corcoba A. van Steenwyk, G., Mansuy, I.M., Duarte, J.M. (2017). Brain metabolic alterations in mice subjected to postnatal traumatic stress and in their offspring. J Cereb Blood Flow Metab. In press.

  • Woldemichael, B.T., Jawaid, A. Kremer, E.A., Gaur, N., Krol, J., Marchais, A. and Mansuy I.M. (2016). The microRNAs cluster miR-183/96/182 contributes to long-term memory in a protein phosphatase 1-dependent manner. Nature Comm. 7:12594

  • Gapp, K., Bohacek, J., Grossmann, J., Brunner, A.M., Manuella, F., Nanni, P. and Mansuy I.M. (2016). Potential of environmental enrichment to prevent transgenerational effects of paternal trauma. Neuropsychopharmacol. 41:2749-58.

  • Bohacek, J., von Werdt, S. and Mansuy I.M. (2016). Probing the germline-dependence of non-genetic inheritance using artificial insemination in mice. Environm. Epigenetics 2:15-25.

  • Bohacek, J., Farinelli, M., Mirante, O., Steiner G., Gapp, K., Coiret, G., Eberling, M., Durán-Pacheco, G., Iniguez, A.L., Manuella, M., Moreau J.-L. and Mansuy I.M. (2015). Pathological brain plasticity and cognition in the offspring of males subjected to postnatal traumatic stress. Mol. Psych. 20:621-31.

  • Bohacek, J., Manuella, F., Roszkowski, M. and Mansuy I.M. (2015). Hippocampal gene expression induced by cold swim stress depends on sex and handling Psychoneuroendocrinol. 52:1-12.

  • Bohacek, J. and Mansuy, I.M. (2015). Emerging insight into non-genetic transgenerational inheritance of acquired behaviors. Nature Rev. Genetics. 16:641-52.



Complete list of publications

Selected projects

  • Swiss National Science Foundation: Study of the epigenetic mechanisms of transgenerational inheritance in mice

  • Swiss National Science Foundation: Study of calcineurin- and PP1-dependent pathways involved in learning and memory formation

Membership in scientific bodies/juries

  • • Member of the Executive Committee of D-HEST, ETHZ

    • Associated member of the Department of Biology, ETHZ

    • Member of the Swiss Academy of Medical Science

    • Member of the Research Council of the Swiss National Foundation, Division IV

    • Chair of the Review Panel Systems Biology, SystemsX

    • Member of the scientific committee of the Theodore-Ott prize

    • Member of the scientific committee of the Robert Bing Prize

    • EMBO member (www.embo.org)

    • Member of the PhD program of Molecular Genetics, Biotechnology and Experimental Medicine, University of Brescia

    • Member of the European Cancer and Environmental Research Institute, Brussels

    • Member of the Extended Management Council of the National Center of Competence in Research (NCCR) “Neural Plasticity and Repair” (www.nccr-neuro.ethz.ch) till 2013

    • Head of the Center of Transgenesis Expertise for the National Center of Competence in Research (NCCR) “Neural Plasticity and Repair” (www.nccr-neuro.ethz.ch) till 2013

    • Scientific Advisory Panel Member of European College of Neuropsychopharmacology (ECNP)

    • Member of committee for Boerhringer Ingelheim FENS Research Award

    • Member of the Research Council of the Jérôme Lejeune Foundation, France (till 2015)

    • Member of the Scientific Advisory Board, 6th FP EU project Promemoria (http://plab.ku.dk/promemoria) (till 2014)

    • Member of the scientific council of the Fyssen Foundation, France (till 2012)

    • Member of the scientific advisory board of European Neuroscience Institute Göttingen, Germany

    • Member of the review board for German Federal Ministry of Education and Research, Germany

    • Member of review boards for the Agence Nationale de la Recherche, France

    • Member of the Recruitment Committee for Nestlé Chair, EPFL

    • Council Member of the Molecular and Cellular Cognition Society, USA (www.molcellcog.org)

    • Member of scientific evaluation committees for the CNRS, France (1-2/year)

    • Member of evaluation committee, Riken Brain Science, Tokyo, Japan

    • Member of the American Society for Neuroscience (SFN)

    • Member of the Federation for European Neuroscience Society (FENS)

    • Member of the International Brain Research Organization (IBRO)

    • Member of the European Brain Behavior Society (EBBS)

    • Member of the French Society for Neuroscience

    • Member of the Swiss Laboratory Animal Science Association

Additional qualifications

  • Professor in Neuroepigenetics

    Brain Research Institute, Medical Faculty of the University Zürich and Department of Health Science and Technology of the Swiss Federal Institute of Technology, Neurosciences Center Zürich

    Zürich, Switzerland, 2004

  • Assistant Professor in Neurobiology, Department of Biology, Swiss Federal Institute of Technology Zürich, Switzerland, 1998


Soft Skills/Other activities and achievements

Additional interests

  • Consulting


Other activities and achievements/family

  • Married and one daughter


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News

  1. Early Trauma Influences Behaviour

    Traumatic events during childhood increase the risk of psychiatric disorders, but they can also help to deal better with difficult situations later in life. Isabelle Mansuy's research team has studied this positive side effect in mice, focussing on the passing on of these traits to the next generation.