Short CV/Education and training

  • 1988 – 1991
    BA in chemistry at the University of Cologne, Germany

  • 1991 – 1994
    Master in chemistry at the University of Cologne

  • 1994
    Diplom degree and Master in chemistry at the Max Planck Institute in Cologne

  • 1995 – 1997
    PhD thesis, Goethe University Frankfurt and the University of Cologne

  • 1997
    PhD at the University of Cologne

  • 1997 – 1998
    Research assistant at the Goethe University Frankfurt, Germany

  • 1998 – 1999
    Postdoctoral Fellow (fellowship from the German Research Foundation (DFG)), University of Seattle, WA, USA

  • 1999 – 2000
    Postdoctoral Fellow (fellowship from the DFG), University of Rochester, NY, USA

  • 2000 – 2004
    Research assistant at the Goethe University Frankfurt

  • 2004 – 2005
    Habilitation (postdoctoral qualification), experimental medicine (MD), Goethe University Frankfurt

  • 2005 – 2006
    Independent group leader in experimental medicine, Goethe University Frankfurt am Main

  • 2007 – 2013
    Independent group leader in molecular aging research, Leibniz Research Institute for Environmental Medicine (IUF) at Heinrich Heine University

  • since 2014
    Professor at HHU Düsseldorf und IUF – "Leibniz-Institut für Umweltmedizinische Forschung"

Selected publications

  • Haendeler, J. et al.: The third cytoplasmic loop of the Angiotensin II type 1 receptor exerts differential effects on extracellular signal-regulated kinase (ERK1/ERK2) and apoptosis via Ras- and Rap1-dependent pathways. In: Circ Res 86, 2000. S. 729-36.

  • Hoffmann, J. et al.: Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide. In: Circ Res 89, 2001. S. 709-715.

  • Haendeler, J. et al.: Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69. In: Nat Cell Biol 4, 2002. S. 743-749.

  • Haendeler, J. et al.: Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phoshporylation of tyrosine 707. In: Mol Cell Biol 23, 2003. S. 4598-4610.

  • Haendeler, J. et al.: Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells: a novel vasculoprotective function of statins. In: Circulation 110, 2004. S. 856-861.

  • Walter, D.H. et al.: Impaired CXCR4 Signaling Contributes to the Reduced Neovascularization Capacity of Endothelial Progenitor Cells From Patients With Coronary Artery Disease. In: Circ Res 97, 2005. S. 1142-1151.

  • Haendeler, J.: Posttranslational modifications of thioredoxin-1. In: Antioxid Redox Signal 8, 2006. S. 1723-1728.

  • Schröder, P. et al.: Nuclear redox-signaling is essential for apoptosis inhibition in endothelial cells: Important role for nuclear thioredoxin-1. In: Arterioscler Thromb Vasc Biol 27, 2007. S. 2325-2331.

  • Spyridopoulos, I. et al.: Caffeine Enhances Endothelial Repair by an AMPK-Dependent Mechanism. Arterioscler. In: Thromb Vasc Biol 28, 2008. S. 1967-1974.

  • Haendeler, J. et al.: Mitochondrial TERT protects mitochondrial DNA and function in vitro and in vivo. Arterioscler. In: Thromb Vasc Biol 29, 2009. S. 929-935.

  • Lukosz, M. et al.: Nuclear redox signalling. Antioxid. In: Redox Signal 12, 2010. S. 713-742.


Selected projects

  • Transatlantic Network of Excellence, Foundation Leducq (PI: Haendeler), "Redox and Nitrosative Regulation of Cardiac Remodeling: Novel Therapeutic Approaches for Heart Failure" (PIs: Doenst/Haendeler), 2010 – 2014

  • German Research Foundation (DFG) Research Grant (PI: Haendeler), "Regulation of Thioredoxin in Endothelial Cells", until 2012

  • Collaborative Research Centre 612, Sub-project B15 (PI: Haendeler), "Characterization of the molecular mechanisms of caffeine action in the vascular system", 2009 – 2012

  • Collaborative Research Centre 728, Sub-project B5 (PI: Haendeler), "The role of Telomerase and new mitochondrial proteins for the maintenance of mitochondrial function in environmentally induced aging processes", 2007 – 2011

Membership in scientific bodies/juries

Editorial board member:

  • Circulation Research

  • Nitric Oxide

  • Arteriosclerosis Thrombosis Vascular Biology

Reviewer:

  • Arteriosclerosis Thrombosis Vascular Biology

  • Circulation

  • Circulation Research

  • Nitric Oxide

  • American Journal of Physiology

  • Cardiovascular Research

  • Experimental Gerontology

  • Journal of Experimental Medicine

  • Aging Cell

  • Antioxidants and Redox Signalling

  • Journal of Cell Science

Committee activities:

  • Member of the board of the Collaborative Research Centre 728 "Environment-induced aging processes"

  • Member of the board of the Biologisch-Medizinisches Forschungszentrum (BMFZ – Research Centre for Biology and Medicine) at Heinrich Heine University

  • Chairperson of Section I of the German Society of Gerontology and Geriatrics (DGGG)

Additional qualifications

  • Head of a genetic engineering laboratory (qualification)


Soft Skills/Other activities and achievements

Soft Skills

  • Timely completion of dissertations and publication output

  • Many years of experience teaching and supervising doctoral students

  • Diplom students, Master students and Bachelor students

  • Skills working collaboratively and in teams


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News

  1. Judith Haendeler Is Heisenberg Professor

    Judith Haendeler, group leader at the Leibniz Research Institute for Environmental Medicine IUF, was appointed W2-professor by the president of the Heinrich-Heine University Düsseldorf, after she was previously awarded a Heisenberg professorship by the Deutsche Forschungsgemeinschaft DFG.