Short CV/Education and training

Postgraduate professional career

  • Since 2009
    Full Professor (W3) for Biophysics, Faculty of Medicine, Saarland University

  • 2001 – 2008
    Research Assistant, Institute of Physiology, University of Tübingen and Tübingen Hearing Research Centre (THRC), Junior Research Group

  • 1999 – 2001
    Scholarship, German Research Council (DFG) at the Institute of Physiology, University of Tübingen

  • 1997 – 1999
    Stipend, State Baden-Württemberg, Institute of Physiology, University of Tübingen

  • 1993 – 1996
    Postdoc, Institute of Physiology, University of Göttingen

  • 1990 – 1993
    Postdoc, Max Planck Institute for Biophysical Chemistry, Göttingen

Miscellaneous

  • Since 2013
    Co-coordinator, DFG Priority Programme “Ultrafast and temporally precise information processing: Normal and dysfunctional hearing”, together with E. Friauf, University of Kaiserslautern

  • 2013
    - 2016 Member, CRC 1027 “Physical modelling of non-equilibrium processes in biological systems”

  • Since 2012
    Member, IRTG1830 “Complex membrane proteins in cellular development and disease”

  • Since 2011
    Member, CRC 894 “Ca2+ Signals: Molecular Mechanisms and Integrative Functions”

  • 2008
    Professorship offered for “Experimental Hearing Research”, Charité – Universitätsmedizin Berlin, declined

  • 2006 – 2010
    Member, EU Research and Training Network “CavNET – Calcium channels in health and disease“

  • 1988 – 1989
    Guest scientist at the Frumkin Institute for Bioelectrochemistry, Academy of Sciences, Moscow, Soviet Union (07-08/1988 and 10/1989)

  • 1988
    Diploma in Biophysics, Supervisor: Doz. Dr. E. Donath

  • 1983 – 1988
    Studies of Biophysics, Humboldt University, Berlin

Selected publications

  • Fell B, Eckrich S, Blum K, Eckrich T, Hecker D, Obermair GJ, Flockerzi V, Münkner S, Schick B, Engel J (2016). 22 controls the function and trans-synaptic coupling of Cav1.3 channels in mouse inner hair cells and is essential for normal hearing. J Neurosci 36, 11024-11036.

  • Scharinger A, Eckrich S, Vandael DH, Schönig K, Koschak A, Hecker D, Kaur G, Lee A, Sah A, Bartsch D, Benedetti B, Lieb A, Schick B, Singewald N, Sinnegger-Brauns MJ, Carbone E, Engel J, Striessnig J (2015). Cell-type-specific tuning of Cav1.3 Ca2+-channels by a C-terminal automodulatory domain. Frontiers Cell Neurosci 9, 309.

  • Pirone A, Kurt S, Zuccotti A, Rüttiger L, Pilz P, Brown DH, Franz C, Schweizer M, Rust MB, Rübsamen R, Friauf E, Knipper M, Engel J (2014). 23 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders. J Neurosci 34, 434-445.

  • Duncker SV, Franz C, Kuhn S, Schulte U, Campanelli D, Brandt N, Hirt B, Fakler B, Blin N, Ruth P, Engel J, Marcotti W, Zimmermann U, Knipper M (2013). Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells. J Neurosci 33, 9508-9519.

  • Jaumann M, Dettling J, Gubelt M, Zimmermann U, Gerling A, Paquet-Durand F, Feil S, Wolpert S, Franz C, Varakina K, Xiong H, Brandt N, Kuhn S, Geisler HS, Rohbock K, Ruth P, Schlossmann J, Hütter J, Sandner P, Feil R, Engel J, Knipper M, Rüttiger L (2012). cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Nat Med 18, 252-259.

  • Baig SM, Koschak A, Lieb A, Gebhart M, Dafinger C, Nürnberg G, Ali A, Ahmad I, Sinnegger-Brauns MJ, Brandt N, Engel J, Mangoni ME, Farooq M, Khan HU, Nürnberg P, Striessnig J, Bolz HJ (2011). Loss of Cav1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness. Nat Neurosci 14, 77-84.

  • Johnson SL, Franz C, Kuhn S, Furness DN, Rüttiger L, Münkner S, Rivolta MN, Seward EP, Herschman HR, Engel J, Knipper M, Marcotti W (2010). Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses. Nat Neurosci 13, 45-52.

  • Brandt N, Kuhn S, Münkner S, Braig C, Winter H, Blin N, Vonthein R, Knipper M, Engel J (2007). Thyroid hormone deficiency affects postnatal spiking activity and expression of Ca2+ and K+ channels in rodent inner hair cells. J Neurosci 27, 3174-3186.

  • Knirsch M, Brandt N, Braig C, Kuhn S, Hirt B, Münkner S, Knipper M, Engel J (2007). Persistence of Cav1.3 Ca2+ channels in mature outer hair cells supports outer hair cell afferent signaling. J Neurosci 27, 6442-6451.

  • Platzer J, Engel J, Schrott-Fischer A, Stephan K, Bova S, Chen H, Zheng H, Striessnig J (2000). Congenital deafness and sinoatrial node dysfunction in mice lacking class D L-type Ca2+ channels. Cell 102, 89-97.


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