Short CV/Education and training

  • Liesbet Geris is professor in Biomechanics and Computational Tissue Engineering at the universities of Liège and Leuven in Belgium. Her research focusses on the multi-scale and multi-physics modeling of biological processes. Together with her team and their clinical collaborators, she uses these models to investigate the etiology of non-healing fractures, to design in silico potential cell-based treatment strategies and to optimize manufacturing processes of these tissue engineering constructs. Liesbet is scientific coordinator of a musculoskeletal Tissue Engineering platform (50+ researchers). She has edited several books on computational modeling and tissue engineering. She has received a prestigious ERC starting grant to finance her research and has received a number of young investigator and early career awards. She is former chair of the Young Academy of Belgium (Flanders), member of the Young Academy of Europe, and member of the strategic alliance committee of the Tissue Engineering and Regenerative Medicine Society. She is the current executive director of the Virtual Physiological Human Institute and in that capacity she advocates the use of in silico modeling in healthcare through liaising with the clinical community, the European Commission and Parliament, regulatory agencies (EMA, FDA) and various other stakeholders. Besides her research work, she is often invited to give public lectures on the challenges of interdisciplinary in research, women in academia and digital healthcare.

Selected publications

  • Guyot, Y., Smeets, B., Odenthal, T., Subramani, R., Luyten, F.P., Ramon, H., Papantoniou, I., Geris, L.. (2016) Immersed Boundary Models for Quantifying Flow-Induced Mechanical Stimuli on Stem Cells Seeded on 3D Scaffolds in Perfusion Bioreactors. PLoS Comput Biol. 22;12(9):e1005108.

  • Kerkhofs, J., Leijten, J., Bolander, J., Luyten, F.P., Post, J.N., Geris, L. (2016). A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy. PLoS One. 11(8):e0162052.

  • Kerckhofs, G., Chai, Y.C., Luyten, F.P., Geris, L. (2016) Combining microCT-based characterization with empirical modelling as a robust screening approach for the design of optimized CaP-containing scaffolds for progenitor cell-mediated bone formation Acta Biomaterialia, 15;35:330-40.

  • Carlier, A., Brems, H., Ashbourn, J.M.A., Nica, I., Legius, E., Geris, L. (2016) Capturing the wide variety of impaired fracture healing phenotypes in Neurofibromatosis Type 1 with eight key factors: a computational study. Scientific Reports, 7:20010.

  • Guyot Y, Papantoniou I, Luyten FP, Geris L. (2016) Coupling curvature-dependent and shear stress-stimulated neotissue growth in dynamic bioreactor cultures: a 3D computational model of a complete scaffold. Biomechanics and Modeling in Mechanobiology. 15(1):169-80.

  • Geris L, Reed AA, Vander Sloten J, Simpson AH, Van Oosterwyck H. Occurrence and treatment of bone atrophic non-unions investigated by an integrative approach. PLoS Comput Biol. 2010 Sep 2;6(9):e1000915.

  • Geris L, Gerisch A, Sloten JV, Weiner R, Oosterwyck HV. Angiogenesis in bone fracture healing: a bioregulatory model. J Theor Biol. 2008 Mar 7;251(1):137-58.


Selected projects

  • Interreg NL-VL project: PROPEROS: PRinting PERsonalized orthopaedic implantS (co-PI, WP leader), 2016 – 2020

  • Marie Sklodowska Curie ETN training network: CARBON: Controlling Cartilage to Bone Transitions for Improved Treatment of Bone Defects and Osteoarthritis (co-PI, WP leader), 2017 – 2020

  • BIOWIN project (regional funding for translational research): BIOPTOS : 3D printed biomaterials optimized for bucco-dental bone regeneration (co-PI ; PI : Eric Rompen, ULG), 2016 – 2019

  • FNRS FRFC projects for fundamental research, 2016 – 2020, 2013 – 2015 & 2012 – 2015

  • KU Leuven internal funding projects for fundamental and translational research, 2017 – 2021 & 2015 – 2017

  • Hercules project for large equipment: NanoCT and BioreactorCT for a better understanding of the dynamics of 3D tissue formation in regenerative medicine: from clustered cells towards organized multi-tissue system and whole organs (co-PI, PI: Frank Luyten, KU Leuven), 2014 – 2016

  • * ERC Starting Grant: ‘Biomimetic process design for tissue regeneration: from bench to bedside via in silico modelling’ (PI), 2011 – 2016

Membership in scientific bodies/juries

  • Member (and Executive Director) of Virtual Physiological Human Institute

  • Member of Young Academy of Europe, 2012 – 2017

  • Member (and former chair) of Young Academy of Belgium, 2013 – 2018

  • Member of Royal Flemish Engineering Society

  • Member of European Society of Biomechanics

  • Member of Tissue Engineering & Regenerative Medicine International Society (member of strategic alliance committee)

  • Member of European Society of Mathematical and Theoretical Biology

  • Member of Academic Foundation Leuven

Media coverage

  • Media coverage in Dutch and French speaking national written and oral media on research work related to in silico medicine and regenerative medicine as well as policy work related to interdisciplinarity, 3Rs, digital health and gender in academia.

Soft Skills/Other activities and achievements

Soft Skills

  • Communication

    Management

    Team building


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