Short CV/Education and training

  • 1992
    Medical Doctor degree, Erasmus University Rotterdam

  • 1992 – 1993
    Research fellow (project "Activation of human prorenin"), department of Nephrology and Hypertension, Erasmus Medical Center Rotterdam (Dr. F.H.M. Derkx, Prof. Dr. M.A.D.H. Schalekamp)

  • 1993
    Residency Internal Medicine, UMC Utrecht (Prof. Dr. D.W. Erkelens) and Eemland Hospital Amersfoort (Dr. A. van de Wiel)

  • 1999
    PhD Utrecht University (Cum Laude), department of Nephrology and Hypertension. Promotores: Prof. Dr. T.J. Rabelink, Prof. Dr. H.A. Koomans

  • 2000
    Board Certification Internal Medicine

  • 2003
    Board Certification Vascular Medicine

  • 2003
    Head of research laboratory Renal and Vascular Biology / Regenerative Vascular Medicine, University Medical Center Utrecht

  • 2009
    Visiting professor at Renal Research Institute, New York Medical College, department of Nephrology (Prof. Dr. M.S. Goligorsky)

  • 2009
    Professor of Experimental Nephrology, Utrecht University

  • 2012
    Board Certification Nephrology

Selected publications

  • Rookmaaker, M.B., Vergeer, M., van Zonneveld, A.J., Rabelink, T.J., Verhaar, M.C. Endothelial progenitor cells: mainly derived from the monocyte/macrophage-containing CD34- mononuclear cell population and only in part from the hematopoietic stem cell-containing CD34+ mononuclear cell population. (2003) Circulation, 108 (21). Impact factor 15.202.

  • Verhaar, M.C., Wever, R.M.F., Kastelein, J.J.P., Van Loon, D., Milstien, S., Koomans, H.A., Rabelink, T.J. Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia: A randomized placebo-controlled trial. (1999) Circulation, 100 (4), pp. 335-338. Impact factor 15.202.

  • Verhaar, M.C., Strachan, F.E., Newby, D.E., Cruden, N.L., Koomans, H.A., Rabelink, T.J., Webb, D.J. Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade. (1998) Circulation, 97 (8), pp. 752-756. Impact factor 15.202.

  • Verhaar, M.C., Wever, R.M.F., Kastelein, J.J.P., Van Dam, T., Koomans, H.A., Rabelink, T.J. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. (1998) Circulation, 97 (3), pp. 237-241. Impact factor 15.202.

  • Westerweel, P.E., Visseren, F.L.J., Hajer, G.R., Olijhoek, J.K., Hoefer, I.E., De Bree, P., Rafii, S., Doevendans, P.A., Verhaar, M.C. Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy. (2008) European Heart Journal, 29 (22), pp. 2808-2817. Impact factor 14.097.

  • Teraa, M., Fledderus, J., Rozbeh, R.I., Leguit, R.J., Verhaar, M.C. Bone marrow microvascular and neuropathic alterations in critical limb ischemia patients. (2013) Circulation Research. Article in Press. Impact factor 11.861.

  • Westerweel, P.E., Verhaar, M.C. Editorial: Directing myogenic mesenchymal stem cell differentiation (2008) Circulation Research, 103 (6), pp. 560-561. Impact factor 11.861.

  • Westerweel, P.E., Verhaar, M.C. Endothelial progenitor cell dysfunction in rheumatic disease. (2009) Nature reviews. Rheumatology, 5 (6), pp. 332-340. Impact factor 9.745.

  • Westerweel, P.E., Luijten, R.K.M.A.C., Hoefer, I.E., Koomans, H.A., Derksen, R.H.W.M., Verhaar, M.C. Haematopoietic and endothelial progenitor cells are deficient in quiescent systemic lupus erythematosus

    (2007) Annals of the Rheumatic Diseases, 66 (7), pp. 865-870. Impact factor 9.111.

  • van Balkom, B.W., de Jong, O.G., Smits, M., Brummelman, J., den Ouden, K., de Bree, P.M., van Eijndhoven, M.A., Pegtel, D.M., Stoorvogel, W., Würdinger, T., Verhaar, M.C. Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells. (2013) Blood, 121 (19), pp. 3997-"4006, S1-400615". Impact factor 9.060.



Complete list of publications

Selected projects

  • Towards a clinical strategy of bone marrow-derived progenitor cell therapy to halt progression of chronic kidney disease. NWO/ZonMw VIDI Career Development Award and ASPASIA Award; Dutch Kidney Foundation.

  • The Juventas-trial: Intra-arterial infusion of autologous bone marrow mononuclear cells in patients with chronic critical limb ischemia: a randomized, double-blinded, placebo-controlled clinical trial. Dutch Heart Foundation and Catharijne Stichting and Stichting Het Dirkzwager-Assink Fonds.

  • Developing bone marrow-derived progenitor cell therapy for critical limb ischemia. NWO/ ZonMw, Translational Adult Stem Cell Research.

  • Generation of whole kidneys from pluripotent stem cells, a novel therapeutic avenue for the treatment of chronic kidney disease. Dutch Kidney Foundation Innovation grant and Vrienden van het UMC Utrecht, Dirkzwager-Assink fund. (Collaboration with Prof. Dr. N. Geijsen, Hubrecht Institute)

  • NOCTX: Is progression of arteriosclerosis in ESRD patients inhibited by nocturnal hemodialysis or renal

    transplantation? (Collaboration Dianet and VU University Medical Center Amsterdam). Vrienden van het UMC Utrecht, Stichting Wellerdieck-de Goede Fund.

Membership in scientific bodies/juries

  • Program Management Team of one of the six Focus Areas in the UMC Utrecht: Speerpunt Stem Cells and Regenerative Medicine

  • Steering Committee Utrecht Cardiovascular Cohort, Focus Area Circulatory Health, UMC Utrecht

  • Scientific Committee Division of Internal Medicine and Dermatology, UMC Utrecht

  • Fellowship Clinical Research Talent UMC Utrecht, since 2010 (chair since 2012)

  • Honours programme / Excellent trace Committee UMC Utrecht, since 2010

  • ZonMw Programme Committee Translational Research (Netherlands Organization for Scientific Research, NWO)

  • ZonMw Programme Committee Innovational Research Incentives Scheme Veni (NWO)

  • NWO Innovational Research Incentives Scheme Vidi (interdivisional)

  • Diabetes Expert Network, Netherlands Diabetes Federation, 2010

  • Workshop advisor Mozaiek Programma van NWO, 2009

  • Editorial Board Member "The Open Atherosclerosis & Thrombosis Journal", 2008

  • DutchFoRM/ZonMw subcommittee "RM future perspectives, Care".

  • Projectgroup "Renal Epithelial (Stem) Cells" in the Dutch Kidney Foundation program 'Bioartificial kidney'.

  • International Review Board Academy of Finland, 2011

  • Review Committee Regenerative Medicine proposals European Committee, 2009

Media coverage

  • Tentoonstelling in het Universiteitsmuseum Utrecht, Onderzoek in beeld: EEN MEDICIJN TEGEN ADERVERKALKING (2008 – 2009), vervolgens deeltentoonstelling in Centrale Hal UMC Utrecht

  • Jubilee book Jaarprijs Vascular Biology: portraits of 10 scientists. Special edition for the occasion of 10x Jaarprijs Vascular Biology, portraits of 10 winners.

  • Interviews in several local newspapers UMC krant, Uniek, U-blad, digderbij, ZonMw Mediator, Diabc magazine, Nederlands Tijdschrift voor Nefrologie: (http://www.ntvn.org/artikel/pdf/NTvN_2012-4_p16-19.pdf)

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